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Mexedrone
3-Methoxy-2-(methylamino)-1-(p-tolyl)propan-1-one
4-MMC-MeOOpen in Piru
Mexedrone is a synthetic substituted cathinone1 described as a stimulant and entactogen, although anecdotal reports suggest that its effects are often mild or absent. It is closely related to mephedrone, with an additional methoxy group,1 and is reported to be substantially less potent. It appeared on the research chemical market in August 2015,1 with little documented human use before its release.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Threshold~50 mg
Light50-80 mg
Moderate80-120 mg
Strong120-200 mg
Heavy200+ mg
Duration
Onset5 minutes
Total3 hours
Subjective Effects
Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.
Effects vary widely by individual, dose, and context.
Physical
Cognitive
Auditory
Pharmacology
Pharmacodynamics
Mexedrone weakly inhibits the reuptake of serotonin, norepinephrine, and dopamine. It also acts as a weak serotonin releasing agent1, increasing serotonin availability through both release and reduced reuptake.
Pharmacokinetics
Absorption & half-lifenot documented yetMetabolitesnone documented yet
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Prolonged, repeated use of mexedrone produces tolerance to many of its effects, requiring larger doses to achieve the same effects.
Tolerance returns to baseline in approximately 1–2 weeks without further use.
Tolerance falls to approximately half within 3–7 days without further use.
All dopaminergic stimulants
Harm Potential
Addiction & Dependence
Psychological
ModerateChronic mexedrone use is moderately addictive, with high abuse potential and psychological dependence in some users. Once addiction develops, stopping use abruptly may cause cravings.
Physical
Withdrawal effects may occur after abrupt discontinuation in users who have developed addiction.
Toxicity
The exact toxic dose of mexedrone is unknown.
History & Culture
Mexedrone had little to no documented history of human use before its release in August 2015 as a research chemical. It was sold online as a designer drug and primarily marketed as a legal alternative to mephedrone. It may have been developed in response to another mephedrone derivative,…
Legality
By Country
Illegal2
SwedenMexedrone is illegal
SwitzerlandIllegalVerordnung des EDI vom 30. Mai 2011 über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien (Betäubungsmittelverzeichnisverordnung, BetmVV-EDI), Anhang 6, Verzeichnis e, Nummer 207234
Mexedrone is listed as Mexedron, with its systematic chemical identity, at number 207 in Annex 6, Verzeichnis e, of the Betäubungsmittelverzeichnisverordnung. Verzeichnis e materials are subject to the control measures applicable to Verzeichnis a narcotics; cultivation, manufacture, import, export, storage, use, or placing on the market requires authorization from the Federal Department of Home Affairs and compliance with its conditions. Unauthorized cultivation, manufacture, import, export, storage, use, or placing on the market is punishable by up to three years’ imprisonment or a monetary penalty under Article 20(1)(c) of the Betäubungsmittelgesetz.
References
Source Pages
Citations
Further Reading
Article Status
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