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Substances Effects Reports

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Community harm-reduction information. Not medical advice. Content is available under the CC BY-SA 4.0 license.

Sigma-1 receptor agonist

10 substances share this mechanism of action.

Sigma-1 receptor agonist (General (no qualifier))7 Sigma-1 receptor agonist (Ki = 629 nM)1 Sigma-1 receptor agonist (Ki 42 nM)1 Sigma-1 receptor agonist (weak)1

Sigma-1 receptor agonist (general)

7 substances

Psychedelic(1)

Common(1)

DMT

Dissociative(6)

Common(2)

Dextromethorphan
Ketamine

Arylcyclohexylamine(4)

3-HO-PCP
3-MeO-PCE
3-MeO-PCMo
3-MeO-PCPr

Sigma-1 receptor agonist (Ki = 629 nM)

1 substance

Dissociative(1)

Diarylethylamine (substituted)(1)

Ephenidine

Sigma-1 receptor agonist (Ki 42 nM)

1 substance

Dissociative(1)

Arylcyclohexylamine(1)

3-MeO-PCP

Sigma-1 receptor agonist (weak)

1 substance

Dissociative(1)

Other dissociatives(1)

Memantine