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MDEA

MDEA molecule structureMDEA molecule structure
3,4-Methylenedioxy-N-ethylamphetamine
MDE, EveOpen in Piru
Psychoactive Class
Chemical Class

MDEA is a synthetic entactogen and stimulant of the substituted amphetamine class1, closely related to MDMA and MDA.1 It was introduced for recreational use in the United States in 1985.2 Its effects are generally described as milder and shorter lasting than those of MDMA, with a more sedating quality reported at high doses. MDEA was among the substances found in tablets sold as ecstasy during the mid-1990s.3

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold40 mg
Light80-100 mg
Moderate100-150 mg
Strong150-200 mg
Heavy225+ mg

Duration

Onset20-60 minutes
Come Up15-30 minutes
Peak1.5-2 hours
Offset1-2 hours
After Effects12-48 hours
Total3-6 hours

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → purple2 → black3 → black3 → black3 → black3
Mecke(ME)
white → black3 → black3 → black3 → black3
Mandelin(MD)
yellow2 → blue2 → black3 → black3 → black3 → black3
Liebermann(LB)
white → blue2 → black3 → black3 → black3
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Pharmacology

Pharmacodynamics

MDEA promotes the release of serotonin, norepinephrine, and dopamine and inhibits their reuptake, increasing their levels in the brain. Its serotonin-releasing activity is relatively greater than its dopamine-releasing activity.1 MDEA also stimulates the release of oxytocin, prolactin, and antidiuretic hormone.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

5-HTPAlcoholCocaineDXMDissociativesMAOIsMDMAMXENBOMe compoundsSNRIsSSRIsSerotonin releasersStimulantsTramadol
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Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
Tolerance to many of MDEA's effects develops with prolonged, repeated use. Empathic effects may diminish substantially while stimulation and euphoria remain, with some users reporting loss of empathic qualities after as few as 10 experiences and others only after hundreds of uses. Some users report no decline in experience quality despite dozens or hundreds of uses.
Baseline Reset
Tolerance returns to baseline after approximately 2–3 months, provided no further MDEA is consumed.
Half Tolerance
Tolerance takes approximately 1–1.5 months to decrease by half, provided no further MDEA is consumed.
Cross Tolerance

Dopaminergic stimulants, Serotonergic stimulants, Entactogens

Harm Potential

Addiction & Dependence

Psychological

Moderate

With ongoing use, MDEA may produce moderate addiction risk, substantial abuse potential, and psychological dependence in some users. After dependence has formed, abrupt cessation can be followed by cravings and withdrawal effects.

Physical

Low

Physical dependence is not prominently characterized, though withdrawal effects including cravings may occur with chronic use.

Toxicity

Central Nervous System

Repeated or high doses of MDEA are likely to carry neurotoxic risk. As a potent serotonin releaser, it is believed to reduce serotonin reuptake transporter availability in the brain, and the timeline for recovery remains uncertain.

Cardiovascular

Heavy MDEA use over extended periods is likely to harm the cardiovascular system and may contribute to valvulopathy; overdose-level exposure can produce acute tachycardia and hypotension.

Hepatic

MDEA and related compounds are hepatotoxic; regular use may cause liver damage.

Thermoregulatory

Hyperthermia is a significant acute risk, particularly with continuous activity without sufficient rest or rehydration; body temperature may rise to dangerous levels.

Musculoskeletal

Overdose may cause muscle rigidity and rhabdomyolysis.

Psychosis Risk

Low

Regular use may lead to schizophrenia-like symptoms according to available sources.

Seizure Risk

Low

Convulsions are listed among overdose symptoms. Risk may be increased when combined with substances that lower seizure threshold.

History & Culture

Alexander Shulgin researched methylenedioxy compounds during the 1960s.4 In a 1967 laboratory notebook entry, he briefly recorded a colleague's report of having experienced no effect from MDEA. Its synthesis and pharmacological evaluation, alongside related…

Legality

International

MDEA (N-ethyl MDA) is listed in Schedule I of the 1971 Convention on Psychotropic Substances. It is not named in the schedules of the 1961 Single Convention, and it is not one of the precursor chemicals in Tables I or II of the 1988 Convention; those latter instruments therefore do not independently schedule/control exact MDEA.

By Country

Illegal28
United States flagUnited StatesIllegal
Argentina flagArgentinaIllegal
Austria flagAustriaIllegal
Belgium flagBelgiumIllegal
Brazil flagBrazilIllegal
Canada flagCanadaIllegal
Chile flagChileIllegal
Finland flagFinlandIllegal
France flagFranceIllegal
Germany flagGermanyIllegal
India flagIndiaIllegal
Indonesia flagIndonesiaIllegal
Ireland flagIrelandIllegal (analog/blanket ban)
Italy flagItalyIllegal
Japan flagJapanIllegal
Netherlands flagNetherlandsIllegal
New Zealand flagNew ZealandIllegal
Philippines flagPhilippinesIllegal
Poland flagPolandIllegal
Russia flagRussiaIllegal
Singapore flagSingaporeIllegal
South Africa flagSouth AfricaIllegal
Spain flagSpainIllegal
Sweden flagSwedenIllegal
Switzerland flagSwitzerlandIllegal
Ukraine flagUkraineIllegal
United Arab Emirates flagUnited Arab EmiratesIllegal
United Kingdom flagUnited KingdomIllegal (analog/blanket ban)
Controlled / restricted2
Australia flagAustraliaRestricted
Denmark flagDenmarkRestricted

References

Source Pages

  1. Erowid
  2. Isomer Design (TiHKAL/PiHKAL)
  3. PiHKAL Entry #106 - MDE
  4. PsychonautWiki
  5. TripSit Factsheets
  6. Wikipedia

Citations

Further Reading

  1. Freudenmann & Spitzer - The Neuropsychopharmacology and Toxicology of MDEA
  2. Stone et al. 1987 - A comparison of the neurotoxic potential of methylenedioxyamphetamine (MDA) and its N-methylated and N-ethylated derivatives
  3. Nash & Nichols 1991 - Microdialysis studies on 3,4-methylenedioxyamphetamine and structurally related analogues
  4. Glennon et al. 1988 - Stimulus properties of 1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDA) analogs

Article Status

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