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LSM-775
LSM-775 is a synthetic psychedelic of the lysergamide class and a close structural relative of LSD.1 In preliminary clinical trials, LSM-775 produced a weak psychedelic response similar to low or threshold doses of LSD2, alongside reportedly dream-like sedation. Albert Hofmann and colleagues described it in the scientific literature by 1955.2 Nausea is a commonly reported adverse effect and can be pronounced.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Pharmacology
Pharmacodynamics
LSM-775 is a potent full agonist at serotonin 5-HT1A receptors2 and a potent partial agonist at 5-HT2A, 5-HT2B, and 5-HT2C receptors. In rodents, it does not produce the head-twitch response, a behavioral marker of psychedelic-like activity. Findings in this model indicate that its 5-HT1A receptor activation suppresses its psychedelic-like effects.2
Pharmacokinetics
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Unsafe
AvoidThere is considerable risk of physical harm when taking these combinations, they should be avoided where possible.
Caution
Use cautionThese combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Likely cross-tolerance with all psychedelics
Harm Potential
Addiction & Dependence
Psychological
Extremely LowLSM-775 is not expected to be habit-forming, and repeated administration may reduce the urge to take it again. Like many psychedelics, it likely has an inherent self-limiting pattern of use.
Toxicity
The precise toxic dose is not known. Scientific studies have not evaluated recreational LSM-775 toxicity or its long-term health effects.
Compared with LSD, LSM-775 shows less evidence of cardiovascular stimulation and peripheral toxicity; intoxication may still involve hypotension, hypertension, or tachycardia.
Nausea is a common adverse effect and may be intense enough to make the experience much less pleasant; vomiting can also occur.
Psychosis Risk
As with other psychedelics, there is potential for adverse psychological reactions including anxiety, paranoia, and panic attacks, though anxiety may be less common than with other psychedelics. Psychosis risk may be elevated in susceptible individuals or when combined with other substances.
Seizure Risk
Seizure risk is inferred from LSD-associated reports. The main concern appears to be for people with genetic susceptibility, especially when stressors such as dehydration, fatigue, or undernourishment are present.
History & Culture
LSM-775 was first described in the scientific literature by Albert Hofmann and colleagues by 1955.2 A paper examining its activity in animals was published in 1957. Alexander Shulgin later included a brief account of the compound in his 1997 book TiHKAL (Tryptamines I Have…
Legality
By Country
GermanyIllegal (analog/blanket ban)
United StatesUncontrolled
SwitzerlandNot scheduledReferences
Source Pages
Citations
Further Reading
Article Status
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