2C-C
2C-C is a psychedelic substance of the substituted phenethylamine class and a member of the 2C-x family.12 It was first synthesized by Cheng and Castagnoli in 19841 and later described in detail by Alexander Shulgin in his 1991 book PiHKAL.3 2C-C is widely regarded as gentler, more relaxed, and more sedating than closely related compounds such as 2C-B, 2C-I, and 2C-E. It remains a lesser-known substance, primarily obtained as a research chemical through online vendors.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Effects vary widely by individual, dose, and context.
Physical
Cognitive
The head space of 2C-C is described by many as one which is both insightful and relatively normal in its thought processes even at moderate to high dosages.
Visual
Distortions
Geometry
The visual geometry of 2C-C can be described as more similar in appearance to that of 4-AcO-DMT or ayahuasca than that of LSD, 2C-B or 2C-I. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large in size, slow and smooth in motion, colourful in scheme, glossy in colour, equally blurred and sharp in their edges and equally rounded and angular in their corners. They give off a contradictory natural and synthetic feel at higher dosages. This substance seems more likely to result in states of Level 8B visual geometry over Level 8A.
Hallucinatory States
2C-C produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics, particularly in comparison to other substances within the phenethylamine family.
Auditory
Reagent Testing
Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.
Pharmacology
Pharmacodynamics
2C-C acts primarily as a partial agonist at serotonin 5-HT2A receptors (49% intrinsic activity), which is believed to underlie its psychedelic effects. It also shows notable affinity for 5-HT2C and 5-HT2B receptors, with higher intrinsic activity at 5-HT2B (81%), and binds 5-HT1A with approximately 15-fold lower affinity than 5-HT2A. The compound has negligible affinity for monoamine transporters and very weak reuptake inhibition,4 but shows high affinity for rat trace amine-associated receptor 1 (TAAR1), though substantially weaker at mouse TAAR1.5 In rodent models, 2C-C has been found to decrease dopamine transporter expression and increase DAT phosphorylation in the nucleus accumbens and medial prefrontal cortex, changes that may elevate extracellular dopamine levels.67
Pharmacokinetics
2C-C-specific human pharmacokinetic parameters, including bioavailability, elimination half-life, clearance, and a validated human metabolite profile, have not been established in the reviewed literature.8 The frequently cited in-vitro enzyme study found MAO-A and MAO-B involvement in deamination of 2C-B, 2C-I, 2C-D, 2C-E, 2C-T-2, and 2C-T-7; it did not test 2C-C. Its MAO result should therefore be described only as evidence from related 2C compounds, not as measured 2C-C metabolism.8
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Unsafe
AvoidThere is considerable risk of physical harm when taking these combinations, they should be avoided where possible.
Caution
Use cautionThese combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Serotonergic psychedelics
Harm Potential
Addiction & Dependence
Psychological
LowWhile anecdotal reports suggest 2C-C is not habit-forming and desire to use may decrease with repeated use, rodent studies have demonstrated reinforcing effects including conditioned place preference and self-administration, suggesting some misuse potential that differs from typical psychedelics.67
Physical
Extremely LowAnecdotal evidence suggests 2C-C is not physically addictive. No withdrawal syndrome has been documented.
Toxicity
Neurotoxicity has been observed at high doses in rodent studies; the relevance to typical human recreational doses is unknown.6
Acute cardiovascular stress including increased blood pressure and heart rate occurs during intoxication, though heart rate elevation may be less pronounced compared to related phenethylamines.
Psychosis Risk
The chance of entering a psychotic or very confused state is relatively low compared to other psychedelics. 2C-C is considered a clear-headed psychedelic overall, though temporary psychosis, paranoia, delusional thinking, and panic attacks remain possible, particularly in individuals with pre-existing mental health conditions.
Seizure Risk
May lower seizure threshold. Contraindicated in individuals with epilepsy or seizure disorders.
History & Culture
2C-C was first synthesized in 1983 by Alice C. Cheng and Neal Castagnoli Jr. at the University of California, San Francisco. The compound was not originally created for its psychoactive properties; rather, it was produced as an intermediate during their investigation of 6-hydroxydopamine analogs…
Trip Reports
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Legality
International
1961 Single Convention: 2C-C is not individually scheduled.
1971 Convention on Psychotropic Substances: 2C-C is not individually scheduled.
1988 Convention: 2C-C is not listed in precursor Tables I or II.
By Country
References
Source Pages
Citations
- Zamberlan F, Sanz C, Martínez Vivot R, Pallavicini C, Erowid F, Erowid E, & Tagliazucchi E. (2018). The Varieties of the Psychedelic Experience: A Preliminary Study of the Association Between the Reported Subjective Effects and the Binding Affinity Profiles of Substituted Phenethylamines and Tryptamines. Frontiers in Integrative Neuroscience, 12, Article 54. https://doi.org/10.3389/fnint.2018.0005412
- Dean BV, Stellpflug SJ, Burnett AM, & Engebretsen KM. (June 2013). 2C or Not 2C: Phenethylamine Designer Drug Review. Journal of Medical Toxicology, 9(2), 172–178. https://doi.org/10.1007/s13181-013-0295-x1
- Shulgin AT, & Shulgin A. (1991). PiHKAL: Phenethylamines I Have Known and Loved — Entry #22: 2,5-DIMETHOXY-4-CHLOROPHENETHYLAMINE (2C-C). PiHKAL: A Chemical Love Story, Article 22. https://erowid.org/library/books_online/pihkal/pihkal022.shtml123
- Amy J. Eshleman, Michael J. Forster, Katherine M. Wolfrum, Robert A. Johnson, Aaron Janowsky, & Michael B. Gatch. (March 2014). Behavioral and neurochemical pharmacology of six psychoactive substituted phenethylamines: mouse locomotion, rat drug discrimination and in vitro receptor and transporter binding and function. Psychopharmacology, 231(5), 875–888. https://doi.org/10.1007/s00213-013-3303-61
- Linda D. Simmler, Danièle Buchy, Sylvie Chaboz, Marius C. Hoener, & Matthias E. Liechti. (April 2016). In Vitro Characterization of Psychoactive Substances at Rat, Mouse, and Human Trace Amine-Associated Receptor 1. The Journal of Pharmacology and Experimental Therapeutics, 357(1), 134–144. https://doi.org/10.1124/jpet.115.2297651
- Young-Jung Kim, Shi-Xun Ma, Kwang-Hyun Hur, Youyoung Lee, Yong-Hyun Ko, Bo-Ram Lee, Seon-Kyung Kim, Su-Jeong Sung, Kyeong-Man Kim, Hyoung-Chun Kim, Seok-Yong Lee, & Choon-Gon Jang. (April 2021). New designer phenethylamines 2C-C and 2C-P have abuse potential and induce neurotoxicity in rodents. Archives of Toxicology, 95(4), 1413–1429. https://doi.org/10.1007/s00204-021-02980-x1234
- Eva Gil-Martins, Daniel José Barbosa, Fernanda Borges, Fernando Remião, & Renata Silva. (June 2025). Toxicodynamic insights of 2C and NBOMe drugs - Is there abuse potential?. Toxicology Reports, 14. https://doi.org/10.1016/j.toxrep.2025.10189012
- Denis S. Theobald, & Hans H. Maurer. (January 2007). Identification of monoamine oxidase and cytochrome P450 isoenzymes involved in the deamination of phenethylamine-derived designer drugs (2C-series). Biochemical Pharmacology, 73(2), 287–297. https://doi.org/10.1016/j.bcp.2006.09.02212
- Synthesis and physicochemical and neurotoxicity studies of 1-(4-substituted-2,5-dihydroxyphenyl)-2-aminoethane analogues of 6-hydroxydopamine. Journal of Medicinal Chemistry, 27(4), 513–520 (April 1984). https://doi.org/10.1021/jm00370a01412
- Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026, sections 1–2 and Schedule classification. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2026L00633/asmade/2026-05-28/text/original/epub/OEBPS/document_1/document_1.html1
- Criminal Code Regulations 2019, Compilation No. 6 (13 December 2025), Schedule 1 item 53. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2019L00561/2025-12-13/2025-12-13/text/original/epub/OEBPS/document_1/document_1.html1
- Criminal Code Act 1995, Compilation No. 174 (in force 30 June 2026), sections 301.1 and 301.4. legislation.gov.au (n.d.). https://www.legislation.gov.au/C2004A04868/2026-06-30/2026-06-30/text/original/epub/OEBPS/document_2/document_2.html1
- Customs (Prohibited Imports) Regulations 1956, Compilation No. 147 (13 July 2026), regulation 5 and Schedule 4 item 5B. legislation.gov.au (n.d.). https://www.legislation.gov.au/F1996B03651/2026-07-13/2026-07-13/text/original/epub/OEBPS/document_1/document_1.html1
- Neue-Psychoaktive-Substanzen-Verordnung (NPSV), consolidated official text, version 27 August 2026. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/GeltendeFassung/Bundesnormen/20007642/NPSV%2c%20Fassung%20vom%2027.08.2026.pdf1
- Neue-Psychoaktive-Substanzen-Verordnung, current Annex II (BGBl. II Nr. 106/2024). ris.bka.gv.at (n.d.). https://ris.bka.gv.at/Dokumente/Bundesnormen/NOR40261441/II_106_2024_Anlage_II.pdf1
- Neue-Psychoaktive-Substanzen-Gesetz (NPSG), consolidated official text, version 27 August 2026. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/GeltendeFassung/Bundesnormen/20007605/NPSG%2c%20Fassung%20vom%2027.08.2026.pdf1
- Resolução RDC nº 6, de 18 de fevereiro de 2014 — ANVISA Lista F2 (2C-C). ANVISA / Agência Nacional de Vigilância Sanitária (n.d.). https://anvisalegis.datalegis.net/action/ActionDatalegis.php?acao=detalharAto&tipo=RDC&numeroAto=00000006&seqAto=000&valorAno=2014&orgao=RDC/DC/ANVISA/MS&nomeTitulo=codigos&desItem=&desItemFim=&cod_modulo=134&cod_menu=16961
- Controlled Drugs and Substances Act, Schedule III. laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-17.html1
- 三部门联合发布最新版《非药用类麻醉药品和精神药品目录》及《关于发布〈非药用类麻醉药品和精神药品目录〉的公告》(2025-07-21). tid.gov.hk (n.d.). https://www.tid.gov.hk/en/tradecircular/files/2025/ci6582025a.pdf1
- 非药用类麻醉药品和精神药品列管办法(公安部、国家卫生计生委、国家药监部门等,2015-09-24). mpa.hunan.gov.cn (n.d.). https://mpa.hunan.gov.cn/mpa/ztzl/jdgz/202010/t20201016_13874433.html1
- 三部门联合发布最新版《非药用类麻醉药品和精神药品目录》. btgaj.xjbt.gov.cn (n.d.). https://btgaj.xjbt.gov.cn/c/2025-07-28/8428464.shtml1
- 非药用类麻醉药品和精神药品列管办法. gaj.panjin.gov.cn (n.d.). https://gaj.panjin.gov.cn/2015_10/08_00/content-235605.html1
- 麻醉药品和精神药品管理条例(国家行政法规库现行文本;2024-12-06第三次修订). xzfg.moj.gov.cn (n.d.). https://xzfg.moj.gov.cn/front/law/detail?LawID=1744&Query=1
- 国务院关于修改和废止部分行政法规的决定(中华人民共和国国务院令第797号;2024-12-06). mee.gov.cn (n.d.). https://www.mee.gov.cn/zcwj/gwywj/202412/t20241216_1098631.shtml1
- Bekendtgørelse om euforiserende stoffer, BEK nr. 405 af 26/03/2026 (current text). retsinformation.dk (n.d.). https://www.retsinformation.dk/eli/lta/2026/405/dan/pdf1
- Bekendtgørelse af lov om euforiserende stoffer, LBK nr. 1334 af 09/12/2019 (current consolidated statute). retsinformation.dk (n.d.). https://www.retsinformation.dk/eli/lta/2019/1334/dan/pdf1
- Finlex current consolidated annex to Government Decree 1130/2014 on psychoactive substances banned from the consumer market. opendata.finlex.fi (n.d.). https://opendata.finlex.fi/finlex/avoindata/v1/akn/fi/act/statute-consolidated/2014/1130/fin@latest/media/8500.pdf1
- Finlex current consolidated Government Decree 1130/2014. opendata.finlex.fi (n.d.). https://opendata.finlex.fi/finlex/avoindata/v1/akn/fi/act/statute-consolidated/2014/1130/fin@latest1
- Finlex current consolidated Narcotics Act 373/2008, section 3(2). opendata.finlex.fi (n.d.). https://opendata.finlex.fi/finlex/avoindata/v1/akn/fi/act/statute-consolidated/2008/373/fin@latest1
- Act 1128/2014 amending chapter 44 of the Finnish Criminal Code. finlex.fi (n.d.). https://www.finlex.fi/api/media/statute/85923/mainPdf/main.pdf?timestamp=2014-12-19T00%3A00%3A00.000Z1
- Gesetz über den Verkehr mit Betäubungsmitteln: Anlage I. (2019). https://www.gesetze-im-internet.de/btmg_1981/anlage_i.html1
- 2,5-Dimethoxy-4-chlorophenethylamine — PubChem CID 29979100. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/compound/2_5-Dimethoxy-4-chlorophenethylamine1
- PubChem PUG REST identity properties for CID 29979100. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/29979100/property/IUPACName,CanonicalSMILES,IsomericSMILES,MolecularFormula,InChIKey/JSON1
- Dangerous Drugs Ordinance [New Version], 5733-1973 — Israeli Ministry of Health legal-information page. gov.il (n.d.). https://www.gov.il/he/pages/samim011
- Dangerous Drugs Ordinance [New Version], 5733-1973 — consolidated Hebrew text. nevo.co.il (n.d.). https://www.nevo.co.il/law_html/law00/4216.htm1
- Dangerous Drugs Notice (Amendment of the First Schedule to the Ordinance), 5785-2025 — Reshumot issue 11879. new.isa.gov.il (n.d.). https://www.new.isa.gov.il/images/Fittings/isa/asset_library_pic/al_lobby/al_lobby-628ce07f9490d/takanot_2025.pdf1
- Inter-ministerial team report on policy regarding prohibition of cannabis consumption in Israel (November 2020). gov.il (n.d.). https://www.gov.il/BlobFolder/reports/canabis-report-criminal-law/he/canabis-report-final_ac.pdf1
- Application for Permit to Import and Export Narcotics and Their Precursors — Ministry of Health. gov.il (n.d.). https://www.gov.il/en/service/importing-and-exporting-narcotic-drugs-and-active-pharmaceutical-ingredients1
- UNODC Drug Laws/Individual Listing for Israel — Dangerous Drug Ordinance 5733-1973 (updated version). unodc.org (n.d.). https://www.unodc.org/LSS/Country/DetailsLegalSystem?code=DLIL&country=IL1
- List of Designated Substances in Japan (as of June 1, 2026). mhlw.go.jp (n.d.). https://www.mhlw.go.jp/content/11120000/001682859.pdf1
- 指定薬物について (About designated substances). mhlw.go.jp (n.d.). https://www.mhlw.go.jp/bunya/iyakuhin/yakubuturanyou/scheduled-drug/index.html1
- 指定薬物を指定する省令が公布されました. mhlw.go.jp (n.d.). https://www.mhlw.go.jp/seisakunitsuite/bunya/kenkou_iryou/iyakuhin/yakubuturanyou/oshirase/20260318-1.html1
- NIH PubChem compound properties for 2C-C (CID 29979100). pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/name/2C-C/property/IUPACName,Title,CanonicalSMILES/JSON1
- Par Krimināllikuma spēkā stāšanās un piemērošanas kārtību, Annex 2, List I II.11(1) (redaction effective 1 December 2025). likumi.lv (n.d.). https://likumi.lv/ta/id/50539-par-kriminallikuma-speka-stasanas-un-piemerosanas-kartibu/redakcijas-datums/2025/12/01#piel21
- Narkotisko un psihotropo vielu un zāļu, kā arī prekursoru likumīgās aprites likums, §§ 3, 5 and 7 (redaction effective 6 March 2026). likumi.lv (n.d.). https://likumi.lv/ta/id/40283-par-narkotisko-un-psihotropo-vielu-un-zalu-likumigas-aprites-kartibu/redakcijas-datums/2026/03/06#p31
- Grozījumi likumā ‘Par Krimināllikuma spēkā stāšanās un piemērošanas kārtību’ (Law No. 364545). likumi.lv (n.d.). https://likumi.lv/ta/id/364545-grozijumi-likuma-par-kriminallikuma-speka-stasanas-un-piemerosanas-kartibu-1
- Förordning (1999:58) om förbud mot vissa hälsofarliga varor, konsolidering 2005:641 — 2,5-dimetoxi-4-klorfenetylamin (2C-C). lagen.nu (n.d.). https://lagen.nu/1999:58/konsolidering/2005:6411
- Verordnung des EDI über die Verzeichnisse der Betäubungsmittel — Anhang 6 (Verzeichnis e), Eintrag 60: 2C-C. Fedlex / Schweizerische Eidgenossenschaft (n.d.). https://www.fedlex.admin.ch/filestore/fedlex.data.admin.ch/eli/cc/2011/363/20231009/de/html/fedlex-data-admin-ch-eli-cc-2011-363-20231009-de-html.html1
- Decision No. 2013/4827: Certain substances made subject to Law No. 2313. resmigazete.gov.tr (n.d.). https://www.resmigazete.gov.tr/eskiler/2013/06/20130625-7.htm1
- Annex to Decision No. 2013/4827. resmigazete.gov.tr (n.d.). https://www.resmigazete.gov.tr/eskiler/2013/06/20130625-7-1.pdf1
- 2,5-Dimethoxy-4-chlorophenethylamine, PubChem CID 29979100. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/compound/2C-C1
- PubChem PUG REST identity properties for CID 29979100. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/29979100/property/IUPACName,CanonicalSMILES,IsomericSMILES,MolecularFormula/JSON1
- 2025 Türkiye Uyuşturucu Raporu. narkotik.pol.tr (n.d.). https://www.narkotik.pol.tr/kurumlar/narkotik.pol.tr/Duyurular/2025/10/2025-Uyusturucu-Raporu.pdf1
- Official Gazette issue index for 13 June 2026. resmigazete.gov.tr (n.d.). https://www.resmigazete.gov.tr/fihrist?tarih=2026-06-131
- Decision No. 11418: Certain substances made subject to Law No. 2313. resmigazete.gov.tr (n.d.). https://www.resmigazete.gov.tr/eskiler/2026/06/20260613-6.pdf1
- 5237 Sayılı Türk Ceza Kanunu. alternatifcozumler.adalet.gov.tr (n.d.). https://alternatifcozumler.adalet.gov.tr/Resimler/icon/5237Say%C4%B1l%C4%B1T%C3%BCrkCezaKanunu.pdf1
- Narkotik Suçlarla Mücadele Başkanlığı national publications index. narkotik.pol.tr (n.d.). https://www.narkotik.pol.tr/ulusalyayinlar1
- Narkolog 2026 Madde Kullanıcıları Profil Analizi. narkotik.pol.tr (n.d.). https://www.narkotik.pol.tr/kurumlar/narkotik.pol.tr/TUB%C4%B0M/Narkolog-2026.pdf1
- Misuse of Drugs Act 1971, Schedule 2 Part I paragraph 1(c) — phenethylamine catch-all. UK National Archives / legislation.gov.uk (n.d.). https://www.legislation.gov.uk/ukpga/1971/38/schedule/21
- 21 CFR § 1308.11(d). ecfr.gov (n.d.). https://www.ecfr.gov/current/title-21/chapter-II/part-1308/section-1308.111
Further Reading
Asanuma et al., 2020 - Neurotoxicity of 2C Series
Eshleman et al., 2014 - Behavioral & Neurochemical Pharmacology
FRANK – Mixing Risks Section
Nervewing: Trip Report - 2C-C (Intranasal)
Nichols D., 2016 - Pharmacology of Psychedelics
Nichols D., 2016 – Pharmacology of Psychedelics
Papaseit et al., 2018 - Acute Effects of 2C-B in Humans
Papaseit et al., 2018 – Acute Effects of 2C-B in Humans
Reddit 2C-C: The Sober Psychedelic
Scarfone et al., 2025 - Toxicodynamic Insights of 2C & NBOMe Drugs
Scarfone et al., 2025 – Toxicodynamic Insights of 2C & NBOMe Drugs
Talk to Frank: 2C Family Drug Facts
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