Loading page
Loading page
Loading substance route
The NBOH family lacks oral bioavailability and requires sublingual administration. The substance must be held in the mouth for 15-25 minutes to permit absorption. Users consistently report an acrid metallic taste and pronounced oral numbness persisting approximately one hour post-absorption. The compound exhibits a highly sensitive dose-response curve with unpredictable subjective effects reported even at similar dosage levels. Insufflation is contraindicated due to documented severe adverse outcomes, including deaths and hospitalizations, associated with closely related NBOMe compounds using this administration route.
These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.
These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.
25C-NBOH is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.
No evidence of physical dependence or withdrawal symptoms has been documented.
The LD50 has not been determined. While no deaths from 25C-NBOH specifically have been reported, it is assumed to share a similar toxicity profile with 25C-NBOMe, which has been linked to multiple deaths and hospitalizations. Fatality is considered possible at heavy doses, with insufflation posing particular risk due to the compound's extreme potency and unpredictable dose-response relationship.
Acute cardiovascular effects including elevated blood pressure, increased heart rate, abnormal heartbeat, and vasoconstriction occur during intoxication; these effects may pose significant risk at higher doses or in individuals with pre-existing cardiovascular conditions.
Temperature regulation suppression and increased body temperature occur during intoxication, which may contribute to dangerous hyperthermia, particularly at high doses or in warm environments with physical activity.
Anxiety and paranoia appear to occur more readily with 25C-NBOH than with many other psychedelics, possibly related to its stimulating properties. At high doses, confusion, amnesia, and sensory overload may occur, potentially increasing vulnerability to adverse psychological reactions.
Seizures are documented as a possible effect. The unpredictable dose-response relationship of this substance may contribute to seizure risk at unexpectedly high effect levels.
25C-NBOH was first synthesized and documented in 2011 by Martin Hansen at the University of Copenhagen. The compound is a derivative of the phenethylamine psychedelic 2C-C, distinguished by the addition of an N-benzyl group bearing a hydroxyl substituent on the benzyl ring.…
Added to Portaria SVS/MS nº 344 on December 10, 2018, which is Brazil's regulatory framework for controlled substances. Possession, distribution, and use are prohibited under federal law.
Classified under Schedule I of the Narcotic Drugs Punishments Act since August 18, 2015, following action by the Riksdag. This scheduling applies to substances, plant materials, and fungi that normally have no accepted medical use. Published by the Medical Products Agency in regulation HSLF-FS 2015:12.
Controlled as a Class A substance under the Misuse of Drugs Act 1971 through the N-benzylphenethylamine catch-all clause. Class A drugs carry the most severe penalties, including up to 7 years imprisonment for possession and life imprisonment for supply offenses.
Controlled under the Neue-psychoaktive-Stoffe-Gesetz (New Psychoactive Substances Act) since November 26, 2016. Production and importation with intent to market, administration to others, and commercial trading are criminally punishable. Possession is technically illegal but carries no criminal penalty.
Specifically named as a controlled substance under Verzeichnis E (Schedule E) of Swiss narcotics legislation. Unauthorized possession, production, and distribution are prohibited.
12 sources cited