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These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.
Controlled internationally under the UN Convention on Psychotropic Substances 1971.
In 2022, this status changed and propylhexedrine has since been removed from control under the Controlled Drugs and Substances Act.
It is sporadically used medicinally.
This was done to satisfy U.S. compliance with an international treaty. However, in 1991, this action was reversed and propylhexedrine was removed from control under the Controlled Substances Act. This was based on the opinion of the Drug Enforcement Administration that propylhexedrine did not warrant control. The substance has remained unregulated under the Controlled Substances Act in the United States ever since. Furthermore, pursuant to DEA regulations, certain Benzedrex inhalers are specifically exempt from the Controlled Substances Act. Propylhexedrine remains regulated under the laws of several U.S. states. These states include the states of Alaska, Arizona, Florida, Georgia, Idaho, Kansas, and Rhode Island.
Initially, propylhexedrine products were available over-the-counter. However, this changed in the 1970s and propylhexedrine is now regulated as a prescription product in Germany.
Propylhexedrine was used recreationally during a brief period in the 1970s after increased government regulation on earlier decongestants.
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