WARNINGMIXING OR WITHDRAWAL CAN BE DANGEROUS
Ordinary doses in combination with other depressants can fatally stop breathing. After prolonged dependency, stopping suddenly can also cause seizures or delirium; seek medical help.
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Medazepam
Medazepam is a benzodiazepine1 depressant and a prodrug of diazepam. It is used to treat anxiety and has effects including sedation, suppression of seizures,1 and skeletal muscle relaxation. It is described as long-acting and habit-forming.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Pharmacology
Pharmacodynamics
Medazepam enhances inhibitory signaling in the cerebral cortex2 through positive allosteric modulation of GABA receptors at the benzodiazepine site.3 Calcium-channel blockade has also been proposed as a possible contributor to its anticonvulsant action at high doses, based on experiments showing reduced depolarization-sensitive calcium uptake in cell components from rat brains.
Pharmacokinetics
Medazepam acts as a prodrug4 and has major active metabolites that are slowly eliminated, making it potentially long-acting.5 Its reported half-life is 36-200 hours.
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Unsafe
AvoidThere is considerable risk of physical harm when taking these combinations, they should be avoided where possible.
Caution
Use cautionThese combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.
Tolerance
Harm Potential
Addiction & Dependence
Psychological
Medazepam can lead to habit formation.7
History & Culture
Legality
References
Source Pages
Citations
Further Reading
Article Status
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