MDPV
MDPV is a synthetic stimulant of the cathinone and pyrrolidine classes,1 first developed in the 1960s by Boehringer Ingelheim as a potential amphetamine alternative.1 It acts primarily as a norepinephrine-dopamine reuptake inhibitor1 and is considered one of the most potent stimulants available.1 MDPV gained notoriety after 2004 when it appeared in products marketed as 'bath salts' sold in convenience stores. It is known for producing strong euphoria with mild empathogenic qualities, though it carries significant risk of compulsive redosing.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Dose figures are tentative and apply to individuals without long-term or short-term tolerance. Compulsive redosing is commonly reported and markedly increases total exposure.
Duration
Subjective Effects
MDPV produces a potent, primarily stimulant experience with only mild entactogenic character, often compared to amphetamine, cocaine, or methylphenidate. The main psychological effects last roughly three to four hours, followed by six to eight hours of residual stimulation and tachycardia during which sleep is difficult. The comedown is frequently described as harsh, and the drug is strongly associated with irresistible cravings to redose beyond what was planned. Higher doses or repeated use shift the experience toward paranoia, confusion, hallucinations, and psychotic behavior.
Physical
Physical effects centre on energetic stimulation with elevated heart rate and blood pressure, jaw tension and tooth grinding, muscle tension and soreness, and involuntary twitching. Some reports describe the body load as concentrated in the head rather than the body, and one account noted a couchlocking quality despite the stimulation.
Cognitive
The headspace is described as clear, motivated, and productive, with euphoria, talkativeness, empathy, and enhanced creativity, though scrambled thinking, confusion, anxiety, and paranoia become prominent as dose rises or use is repeated. A residual depressed mood commonly follows.
Emotional
Enhancements
Visual
Visual input can trigger inappropriate alerting; hallucinatory content is reported at high doses or with repeated use.
Auditory
An increased frequency of auditory-triggered vigilance responses is characteristic, with ordinary perceptual noise prompting inappropriate alerting.
Pharmacology
Pharmacodynamics
MDPV acts as a potent norepinephrine-dopamine reuptake inhibitor (NDRI), with especially pronounced activity at the dopamine transporter. Its IC50 values for dopamine reuptake inhibition are 4.1 nM in rat brain synaptosomes and 10 nM in HEK293 cells, placing it among the most potent dopamine reuptake inhibitors characterized to date. Activity at the dopamine transporter is approximately six to eight times stronger than at the norepinephrine transporter, while the compound is virtually inactive at the serotonin transporter.2 MDPV additionally displays weak partial norepinephrine and dopamine releasing activity, with Emax values of 24% for both catecholamines in rat brain synaptosomes, though no releasing activity was observed in HEK293 cells. The (S)-enantiomer is the pharmacologically active form.2
Pharmacokinetics
MDPV is metabolized hepatically via CYP2D6, CYP2C19, CYP1A2, and catechol-O-methyltransferase (COMT). The metabolic pathway proceeds through demethylenation, methylation of the aromatic ring, hydroxylation of both the aromatic ring and side chain, and oxidation of the pyrrolidine ring to a lactam, followed by ring opening to a carboxylic acid. Phase II glucuronidation then enables renal excretion, with only a small fraction eliminated in the feces.2 In vitro studies have found MDPV to have greater blood-brain barrier permeability than amphetamine, methamphetamine, methcathinone, and mephedrone.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Cocaine and other dopaminergic stimulants
Harm Potential
Addiction & Dependence
Psychological
Extremely HighMDPV is considered highly addictive with a high potential for abuse and readily causes psychological dependence. It is strongly associated with compulsive redosing ('fiending') and irresistible cravings to re-administer, with robust reinforcing effects demonstrated in both human case reports and animal self-administration studies.3
Physical
ModerateWhen addiction develops, cravings and withdrawal effects may occur if usage is suddenly stopped. The drug causes highly unpleasant comedown symptoms including residual depressed mood, cramping, muscle soreness, and prolonged stimulation making sleep difficult.
Toxicity
Acute cardiovascular strain including very elevated heart rate and tachycardia occurs during intoxication and may persist into the comedown period; overdose cases may present with hypertensive emergency requiring emergency treatment.
Psychosis Risk
MDPV may cause psychosis and mania at a significantly higher rate than other stimulants. Chronic abuse or single exposure overdose can lead to psychosis more readily than the vast majority of stimulants. Symptoms include hearing voices, visual hallucinations, urges to harm oneself, severe anxiety, mania, grandiosity, paranoid delusions, confusion, increased aggression, and irritability. High doses cause intense prolonged panic attacks, and sleep deprivation from extended use compounds psychotic risk. Electroconvulsive therapy has been used to treat persistent psychotic symptoms from repeated use.4
Seizure Risk
Seizures can occur in overdose situations and are treated with large doses of lorazepam in emergency settings.
History & Culture
Development and Early History
MDPV was first developed in the 1960s by a research team at Boehringer Ingelheim, a German pharmaceutical company. The compound was investigated as a potential alternative to racemic amphetamine and reportedly demonstrated some desirable qualities, including reduced toxicity compared to
Legality
International
UN Single Convention on Narcotic Drugs 1961: not internationally scheduled under the 1961 Convention
UN Convention on Psychotropic Substances 1971: scheduled7
UN Convention against Illicit Traffic 1988: not internationally scheduled under the 1988 Convention
By Country
References
Source Pages
Citations
- Richard A. Glennon, & Richard Young. (2016). Neurobiology of 3,4-Methylenedioxypyrovalerone (MDPV) and α-Pyrrolidinovalerophenone (α-PVP). Brain Research Bulletin, 126, 111-126. https://doi.org/10.1016/j.brainresbull.2016.04.0111234
- Michael H. Baumann, Muhammad O. Bukhari, Katherine R. Lehner, Sabina Anizan, Kenner C. Rice, Marta Concheiro, & Marilyn A. Huestis. (2017). Neuropharmacology of 3,4-Methylenedioxypyrovalerone (MDPV), Its Metabolites, and Related Analogs. Neuropharmacology of New Psychoactive Substances (NPS), 93–117. https://doi.org/10.1007/7854_2016_531234567
- Watterson LR, Kufahl PR, Nemirovsky NE, Sewalia K, Grabenauer M, Thomas BF, Marusich JA, Wegner S, & Olive MF. (2014). Potent rewarding and reinforcing effects of the synthetic cathinone 3,4-methylenedioxypyrovalerone (MDPV). Addiction Biology, 19(2), 165-174. https://doi.org/10.1111/j.1369-1600.2012.00474.x1
- Penders TM, Lang MC, Pagano JJ, & Gooding ZS. (2013). Electroconvulsive therapy improves persistent psychosis after repeated use of methylenedioxypyrovalerone ("bath salts").. The Journal of ECT, 29(4), e59-e60. https://doi.org/10.1097/yct.0b013e3182887bc21
- European Monitoring Centre for Drugs and Drug Addiction, & Europol. (2014). EMCDDA–Europol Joint Report on a new psychoactive substance: MDPV (3,4-methylenedioxypyrovalerone). Publications Office of the European Union. https://www.drugsandalcohol.ie/21301/1/EMCDDA-Europol_Joint_Report_MDPV.pdf1
- Benzie F, Hekman K, Cameron L, Wade DR, Miller C, Smolinske S, & Warrick B. (2011). Emergency Department Visits After Use of a Drug Sold as “Bath Salts” — Michigan, November 13, 2010–March 31, 2011. Morbidity and Mortality Weekly Report, 60(19), 624–627. https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6019a6.htm1
- United Nations Office on Drugs and Crime. (n.d.). Substance Details: 3,4-Methylenedioxypyrovalerone. UNODC Legal Status and Scheduling. https://www.unodc.org/LSS/Substance/Details/6a35fe21-2cdd-46ff-a343-cd977fa28ff61
- Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026 — Federal Register record. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2026L00633/latest1
- Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2026L00633/asmade/2026-05-28/text/original/epub/OEBPS/document_1/document_1.html1
- Explanatory Statement—Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026. legislation.gov.au (n.d.). https://www.legislation.gov.au/F2026L00633/asmade/2026-05-28/es/original/epub/OEBPS/document_1/document_1.html1
- Medicines and Poisons Act 2014 — Western Australian Legislation. legislation.wa.gov.au (n.d.). https://www.legislation.wa.gov.au/legislation/statutes.nsf/law_a147008.html1
- Medicines and Poisons Act 2014 — current consolidated text. legislation.wa.gov.au (n.d.). https://www.legislation.wa.gov.au/legislation/prod/filestore.nsf/FileURL/mrdoc_48858.htm/$FILE/Medicines%20and%20Poisons%20Act%202014%20-%20%5B00-l0-00%5D.html?OpenElement1
- Medicines and Poisons Regulations 2016 — Western Australian Legislation. legislation.wa.gov.au (n.d.). https://www.legislation.wa.gov.au/legislation/statutes.nsf/law_s48030.html&view=consolidated1
- Medicines and Poisons Regulations 2016 — current consolidated text. legislation.wa.gov.au (n.d.). https://www.legislation.wa.gov.au/legislation/prod/filestore.nsf/FileURL/mrdoc_49666.htm/$FILE/Medicines%20and%20Poisons%20Regulations%202016%20-%20%5B00-t0-00%5D.html?OpenElement1
- RIS Suchtgiftverordnung, Annex IV, consolidated text as at 26 August 2026. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/NormDokument.wxe?Abfrage=Bundesnormen&Anlage=4&Gesetzesnummer=10011053&FassungVom=2026-08-261
- RIS Suchtmittelgesetz section 27, current text. ris.bka.gv.at (n.d.). https://www.ris.bka.gv.at/NormDokument.wxe?Abfrage=Bundesnormen&Gesetzesnummer=10011040&FassungVom=2026-08-26&Artikel=&Paragraf=271
- Belgian Official Journal (Justel), Royal Decree of 6 September 2017 regulating narcotic and psychotropic substances, current consolidated text. ejustice.just.fgov.be (n.d.). https://www.ejustice.just.fgov.be/eli/arrete/2017/09/06/2017031231/justel1
- AFMPS, Annex II non-official consolidated version (valid from 29 March 2026). afmps.be (n.d.). https://www.afmps.be/sites/default/files/content/INSP/NARC/annex%20II_non%20official%20consolidated%20version.pdf1
- AFMPS, Législation - Substances. afmps.be (n.d.). https://www.afmps.be/fr/humain/produits_particuliers/subst_specialement_reglementees/stupefiants_et_psychotropes/substances1
- RDC nº 37, de 3 de julho de 2012, updating Annex I to Portaria SVS/MS nº 344/1998. gov.br (n.d.). https://www.gov.br/anvisa/pt-br/assuntos/medicamentos/controlados/lista-substancias1
- Resolução da Diretoria Colegiada Anvisa nº 1.036, de 9 de julho de 2026. anvisalegis.datalegis.net (n.d.). https://anvisalegis.datalegis.net/action/ActionDatalegis.php?acao=abrirTextoAto&tipo=RDC&numeroAto=00001036&seqAto=000&valorAno=2026&orgao=RDC/DC/ANVISA/MS&codTipo=&desItem=&desItemFim=&cod_menu=1696&cod_modulo=134&pesquisa=true1
- Portaria SVS/MS nº 344, de 12 de maio de 1998. anvisalegis.datalegis.net (n.d.). https://anvisalegis.datalegis.net/action/ActionDatalegis.php?acao=abrirTextoAto&tipo=POR&numeroAto=00000344&seqAto=000&valorAno=1998&orgao=SVS/MS&codTipo=&desItem=&desItemFim=&cod_menu=1696&cod_modulo=134&pesquisa=true1
- Наредба за реда за класифициране на растенията и веществата като наркотични. dv.parliament.bg (n.d.). https://dv.parliament.bg/DVWeb/showMaterialDV.jsp?idMat=581461
- Постановление № 100 от 12 август 2026 г. за изменение и допълнение на Наредбата за реда за класифициране на растенията и веществата като наркотични (State Gazette, issue 73/2026). dv.parliament.bg (n.d.). https://dv.parliament.bg/DVWeb/showMaterialDV.jsp?idMat=2453471
- Наредба за реда за класифициране на растенията и веществата като наркотични (Ministry of Health PDF, amended through State Gazette issue 97/2013). mh.government.bg (n.d.). https://www.mh.government.bg/upload/4355/naredba-red-za-klasifitsirane-na-rasteniyata-i-veshtestvata-kato-narkotichni-08-11-2013.pdf1
- Controlled Drugs and Substances Act (S.C. 1996, c. 19). laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/C-38.8/section-sched95314.html?txthl=s&wbdisable=false1
- Decreto 867, Reglamento de la Ley N.º 20.000 (current Ley Chile text). bcn.cl (n.d.). https://www.bcn.cl/leychile/navegar?idNorma=2693231
- Decreto N.º 1.524, Ministerio del Interior y Seguridad Pública, modifying Decreto N.º 867. bcn.cl (n.d.). https://www.bcn.cl/leychile/navegar?idNorma=10871031
- Ley N.º 20.000 (current Ley Chile text). bcn.cl (n.d.). https://www.bcn.cl/leychile/navegar?idNorma=2355071
- Resolución No. 116 de 2026, modifying the technical annexes to Resolución 315 de 2020. minsalud.gov.co (n.d.). https://www.minsalud.gov.co/Normatividad_Nuevo/Resolucion%20No%20116%20de%202026.pdf1
- NN 19/2023-331, Popis droga, psihotropnih tvari i biljaka iz kojih se može dobiti droga te tvari koje se mogu uporabiti za izradu droga. narodne-novine.nn.hr (n.d.). https://narodne-novine.nn.hr/clanci/sluzbeni/2023_02_19_331.html1
- K.D.P. 367/2025 — Narcotic Drugs and Psychotropic Substances (Controlled Drugs) (Amendment) Order 2025. cylaw.org (n.d.). https://www.cylaw.org/KDP/data/2025_1_367.pdf1
- Narcotic Drugs and Psychotropic Substances Law 29/1977 (consolidated text). cylaw.org (n.d.). https://www.cylaw.org/nomoi/enop/non-ind/1977_1_29/full.html1
- PubChem Compound REST record for MDPV (CID 20111961). pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/name/MDPV/property/IUPACName,CanonicalSMILES/JSON1
- Government Regulation No. 463/2013 Coll., on lists of addictive substances, as amended. e-sbirka.gov.cz (n.d.). https://e-sbirka.gov.cz/sb/2013/4631
- Government Regulation No. 463/2013 Coll., on lists of addictive substances, as amended. e-sbirka.gov.cz (n.d.). https://e-sbirka.gov.cz/sb/1998/1671
- Government Regulation No. 463/2013 Coll., on lists of addictive substances, as amended. e-sbirka.gov.cz (n.d.). https://e-sbirka.gov.cz/sb/2015/2431
- Government Regulation No. 463/2013 Coll., on lists of addictive substances, as amended. e-sbirka.gov.cz (n.d.). https://e-sbirka.gov.cz/sb/2026/1071
- BEK nr 405 af 26/03/2026 (Gældende), Bekendtgørelse om euforiserende stoffer. retsinformation.dk (n.d.). https://www.retsinformation.dk/api/pdf/2559321
- Lægemiddelstyrelsens samlede liste over euforiserende stoffer. laegemiddelstyrelsen.dk (n.d.). https://laegemiddelstyrelsen.dk/~/media/FF630EF9AB8F463DA583EB67DF94D7F9.ashx1
- Liste over euforiserende stoffer, Lægemiddelstyrelsen. laegemiddelstyrelsen.dk (n.d.). https://laegemiddelstyrelsen.dk/da/godkendelse/virksomhedstilladelse-og-registrering/euforiserende-stoffer/liste-over-stoffer/1
- LBK nr 1334 af 09/12/2019 (Gældende), Bekendtgørelse af lov om euforiserende stoffer. retsinformation.dk (n.d.). https://www.retsinformation.dk/api/pdf/2100031
- Regulation No. 73 current-act metadata (Riigi Teataja public API). riigiteataja.ee (n.d.). https://www.riigiteataja.ee/public-api/api/v1/akt/1110820260101
- Narkootiliste ja psühhotroopsete ainete nimekirjad ning nende ainete meditsiinilisel ja teaduslikul eesmärgil käitlemine (current consolidated text). riigiteataja.ee (n.d.). https://www.riigiteataja.ee/public-api/api/v1/akt/111082026010/blob-html1
- Regulation No. 73 Annex 1, Lists I–VI, in the wording of Social Minister Regulation No. 33 (Estonia). riigiteataja.ee (n.d.). https://www.riigiteataja.ee/aktilisa/1110/8202/6010/SOM_06082026_m33_lisa1.pdf1
- Valtioneuvoston asetus huumausaineina pidettävistä aineista, valmisteista ja kasveista | 543/2008 | Ajantasaistettu lainsäädäntö. finlex.fi (n.d.). https://www.finlex.fi/fi/lainsaadanto/2008/5431
- Finlex current consolidated Government Decree 543/2008. opendata.finlex.fi (n.d.). https://opendata.finlex.fi/finlex/avoindata/v1/akn/fi/act/statute-consolidated/2008/543/fin@latest1
- Government Decree 1119/2025 amending Government Decree 543/2008. opendata.finlex.fi (n.d.). https://opendata.finlex.fi/finlex/avoindata/v1/akn/fi/act/statute/2025/1119/fin@1
- Government Decree 651/2026 amending Government Decree 543/2008. opendata.finlex.fi (n.d.). https://opendata.finlex.fi/finlex/avoindata/v1/akn/fi/act/statute/2026/651/fin@1
- Huumausainelaki | 373/2008 | Ajantasaistettu lainsäädäntö. finlex.fi (n.d.). https://www.finlex.fi/fi/lainsaadanto/2008/3731
- Finlex current consolidated Narcotics Act 373/2008. opendata.finlex.fi (n.d.). https://opendata.finlex.fi/finlex/avoindata/v1/akn/fi/act/statute-consolidated/2008/373/fin@latest1
- Sosiaali- ja terveysministeriön asetus lääkkeen määräämisestä | 1088/2010 | Ajantasaistettu lainsäädäntö. finlex.fi (n.d.). https://www.finlex.fi/fi/lainsaadanto/2010/10881
- Finlex current consolidated Prescription Decree 1088/2010. opendata.finlex.fi (n.d.). https://opendata.finlex.fi/finlex/avoindata/v1/akn/fi/act/statute-consolidated/2010/1088/fin@latest1
- Fimea - SPC/PL-haku. spc.fimea.fi (n.d.). https://spc.fimea.fi/1
- ANSM, Liste consolidée des substances classées comme stupéfiants (26 June 2026). ansm.sante.fr (n.d.). https://ansm.sante.fr/uploads/2026/06/26/20260626-stupefiants-version-consolidee.pdf1
- ANSM, Substances vénéneuses (Listes I et II, stupéfiants, psychotropes). ansm.sante.fr (n.d.). https://ansm.sante.fr/documents/reference/substances-veneneuses-listes-i-et-ii-stupefiants-psychotropes1
- Ministère chargé de la santé, PEPPS — Substances vénéneuses. peps.sante.gouv.fr (n.d.). https://peps.sante.gouv.fr/themes/subst_ven/subst.html1
- Betäubungsmittelgesetz, Anlage II. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/btmg_1981/anlage_ii.html1
- § 1 BtMG - Einzelnorm. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/btmg_1981/__1.html1
- 78/2022. (XII. 28.) BM rendelet az ellenőrzött anyagokról. njt.jog.gov.hu (n.d.). https://njt.jog.gov.hu/jogszabaly/2022-78-20-0A1
- 78/2022. (XII. 28.) BM rendelet az ellenőrzött anyagokról. njt.jog.gov.hu (n.d.). https://njt.jog.gov.hu/jogszabaly/2012-66-20-221
- Narcotic Drugs and Psychotropic Substances (Amendment) Rules, 2016, G.S.R. 685(E), 12 July 2016. narcoticsindia.nic.in (n.d.). https://narcoticsindia.nic.in/Notifications/Notification-dated-12.07.2016-notifying-new-Psychotropic-substances-under-NDPS-Act-1985.pdf1
- Acts and Rules, Central Bureau of Narcotics. cbn.gov.in (n.d.). https://www.cbn.gov.in/en/notifications/acts_rules/1
- S.I. No. 199/2010 - Misuse of Drugs Act 1977 (Controlled Drugs) (Declaration) Order 2010. irishstatutebook.ie (n.d.). https://www.irishstatutebook.ie/eli/2010/si/199/made/en/print1
- S.I. No. 173/2017 - Misuse of Drugs Regulations 2017. irishstatutebook.ie (n.d.). https://www.irishstatutebook.ie/eli/2017/si/173/made/en/print1
- S.I. No. 211/2022 - Misuse of Drugs Act 1977 (Controlled Drugs) (Designation) Order 2022. irishstatutebook.ie (n.d.). https://www.irishstatutebook.ie/eli/2022/si/211/made/en/print1
- S.I. No. 405/2025 - Misuse of Drugs (Amendment) Regulations 2025. irishstatutebook.ie (n.d.). https://www.irishstatutebook.ie/eli/2025/si/405/made/en/print1
- S.I. No. 406/2025 - Misuse of Drugs Act 1977 (Controlled Drugs) (Designation) (Amendment) Order 2025. irishstatutebook.ie (n.d.). https://www.irishstatutebook.ie/eli/2025/si/406/made/en/print1
- Free Import Order, 5772-2012 (official Reshumot customs/import regulation). gov.il (n.d.). https://www.gov.il/BlobFolder/legalinfo/customs-mekach-1671/he/customs_mekach_1671.pdf1
- Dangerous Drugs Notice (Amendment of the First Schedule to the Ordinance), 5785-2025 (Reshumot issue 11879). new.isa.gov.il (n.d.). https://www.new.isa.gov.il/images/Fittings/isa/asset_library_pic/al_lobby/al_lobby-628ce07f9490d/takanot_2025.pdf1
- Inter-ministerial team report on policy regarding prohibition of cannabis consumption in Israel (November 2020). gov.il (n.d.). https://www.gov.il/BlobFolder/reports/canabis-report-criminal-law/he/canabis-report-final_ac.pdf1
- UNODC Drug Laws/Individual Listing for Israel — Dangerous Drug Ordinance 5733-1973 (updated version). unodc.org (n.d.). https://www.unodc.org/LSS/Country/DetailsLegalSystem?code=DLIL&country=IL1
- Dangerous Drugs Ordinance [New Version], 5733-1973 — publicly available consolidated Hebrew text (cross-check). he.wikisource.org (n.d.). https://he.wikisource.org/wiki/%D7%A4%D7%A7%D7%95%D7%93%D7%AA_%D7%94%D7%A1%D7%9E%D7%99%D7%9D_%D7%94%D7%9E%D7%A1%D7%95%D7%9B%D7%A0%D7%99%D7%9D1
- Psychoactive Substances — forms, common use, effects and treatment (March 2020). gov.il (n.d.). https://www.gov.il/BlobFolder/guide/psychoactive_drugs_facts/he/PDF_%D7%97%D7%95%D7%9E%D7%A8%D7%99%D7%9D%20%D7%A4%D7%A1%D7%99%D7%9B%D7%95%D7%90%D7%A7%D7%98%D7%99%D7%91%D7%99%D7%99%D7%9D%202020.pdf1
- Decreto del Presidente della Repubblica 9 ottobre 1990, n. 309. gazzettaufficiale.it (n.d.). https://www.gazzettaufficiale.it/atto/serie_generale/caricaArticoloDefault/originario?atto.codiceRedazionale=11A06400&atto.dataPubblicazioneGazzetta=2011-05-16&atto.tipoProvvedimento=DECRETO1
- Ministero della Salute, Decreto 10 febbraio 2015 — Gazzetta Ufficiale Serie Generale n. 48. gazzettaufficiale.it (n.d.). https://www.gazzettaufficiale.it/eli/gu/2015/02/27/48/sg/pdf1
- D.P.R. 9 ottobre 1990, n. 309 — Normattiva current-date view. normattiva.it (n.d.). https://www.normattiva.it/atto/caricaDettaglioAtto?atto.codiceRedazionale=090G0363&atto.dataPubblicazioneGazzetta=1990-10-31&bloccoAggiornamentoBreadCrumb=true&classica=true&dataVigenza=27%2F08%2F2026&generaTabId=true&qId=&tabID=&tipoDettaglio=singolavigenza&title=lbl.dettaglioAtto1
- D.P.R. 9 October 1990, n. 309, Article 14 — criteria for forming the tables. normattiva.it (n.d.). https://www.normattiva.it/uri-res/N2Ls?urn:nir:stato:decreto:1990-10-09;309~art141
- Italian Ministry of Health — tables of narcotic and psychotropic substances. salute.gov.it (n.d.). https://www.salute.gov.it/new/it/tema/medicinali-stupefacenti-e-precursori-di-droghe/tabelle-delle-sostanze-stupefacenti-e/1
- Italian Ministry of Health — linked controlled-substance monitoring PDF. salute.gov.it (n.d.). https://www.salute.gov.it/new/sites/default/files/imported/C_17_pagineAree_3709_0_file.pdf1
- 麻薬、麻薬原料植物、向精神薬、麻薬向精神薬原料等を指定する政令(平成二年政令第二百三十八号)— current e-Gov law-data text. laws.e-gov.go.jp (n.d.). https://laws.e-gov.go.jp/api/1/lawdata/402CO00000002381
- Cabinet Order No. 183 of 4 July 2012 amending the Cabinet Order Designating Narcotics, Narcotic Raw-Material Plants, Psychotropic Substances and Narcotic/Psychotropic Raw Materials. mhlw.go.jp (n.d.). https://www.mhlw.go.jp/web/t_doc?dataId=00tb8467&dataType=1&pageNo=11
- Cabinet Regulation No. 402 of 12 June 2012 (Latvia): amendment to Cabinet Regulation No. 847. likumi.lv (n.d.). https://likumi.lv/ta/id/249106-grozijums-ministru-kabineta-2005gada-8novembra-noteikumos-nr847-noteikumi-par-latvija-kontrolejamajam-narkotiskajam-vielam-psihotropajam-vielam-un-prekursoriem1
- Amendment to the Law on the Procedures for Entry into Force and Application of the Criminal Law (Latvia), 2012. likumi.lv (n.d.). https://likumi.lv/ta/id/2505981
- Law on the Procedures for Entry into Force and Application of the Criminal Law (Latvia), current consolidated text. likumi.lv (n.d.). https://likumi.lv/ta/id/505391
- Version consolidée applicable au 13/07/2026 : Règlement grand-ducal du 20 mars 1974 concernant certaines substances psychotropes. legilux.public.lu (n.d.). https://legilux.public.lu/filestore/eli/etat/leg/rgd/1974/03/20/n1/consolide/20260713/fr/html/eli-etat-leg-rgd-1974-03-20-n1-consolide-20260713-fr-html.html1
- Version consolidée applicable au 08/08/2025 : Règlement grand-ducal du 19 février 1974 portant exécution de la loi du 19 février 1973. legilux.public.lu (n.d.). https://legilux.public.lu/filestore/eli/etat/leg/rgd/1974/02/19/n1/consolide/20250808/fr/html/eli-etat-leg-rgd-1974-02-19-n1-consolide-20250808-fr-html.html1
- Version consolidée applicable au 21/07/2023 : Loi du 19 février 1973 concernant la vente de substances médicamenteuses et la lutte contre la toxicomanie. legilux.public.lu (n.d.). https://legilux.public.lu/filestore/eli/etat/leg/loi/1973/02/19/n1/consolide/20230721/fr/html/eli-etat-leg-loi-1973-02-19-n1-consolide-20230721-fr-html.html1
- Règlement grand-ducal du 6 juillet 2026 portant modification du règlement grand-ducal modifié du 20 mars 1974 concernant certaines substances psychotropes. legilux.public.lu (n.d.). https://legilux.public.lu/filestore/eli/etat/leg/rgd/2026/07/06/a326/jo/fr/html/eli-etat-leg-rgd-2026-07-06-a326-jo-fr-html.html1
- Opiumwet (official BWB XML consolidation BWBR0001941, version effective 2026-07-09). repository.officiele-overheidspublicaties.nl (n.d.). https://repository.officiele-overheidspublicaties.nl/bwb/BWBR0001941/2026-07-09_0/xml/BWBR0001941_2026-07-09_0.xml1
- Opiumwet, official Wetten.nl consolidated legislation portal. wetten.overheid.nl (n.d.). https://wetten.overheid.nl/BWBR0001941/2026-07-091
- Besluit van 4 juni 2015, houdende wijziging van lijst I, behorende bij de Opiumwet, Staatsblad 2015, 237. zoek.officielebekendmakingen.nl (n.d.). https://zoek.officielebekendmakingen.nl/stb-2015-237.html1
- Forskrift om narkotika (narkotikaforskriften) (current consolidated text). lovdata.no (n.d.). https://lovdata.no/dokument/SF/forskrift/2013-02-14-1991
- Forskrift om endring i forskrift om narkotika (narkotikaforskriften), 29 February 2024. lovdata.no (n.d.). https://lovdata.no/dokument/LTI/forskrift/2024-02-29-3571
- Dangerous Drugs Board, Updated Lists of Scheduled Controlled Substances (6 July 2025), under section 93, article XI of Republic Act No. 9165. ddb.gov.ph (n.d.). https://ddb.gov.ph/wp-content/uploads/2025/08/Updated-Lists-of-controlled-substances-as-of-July-2025.pdf1
- Annex A – Philippines Schedules of Dangerous Drugs. ddb.gov.ph (n.d.). https://ddb.gov.ph/images/Board_Regulation/2014/BD.REG1/Annex_A_-_Philippine_Schedules_of_Dangerous_Drugs.pdf1
- Rozporządzenie Ministra Zdrowia w sprawie wykazu substancji psychotropowych, środków odurzających oraz nowych substancji psychoaktywnych, consolidated text Dz.U. 2024 poz. 1139. eli.gov.pl (n.d.). https://eli.gov.pl/eli/DU/2024/1139/ogl1
- Rozporządzenie Ministra Zdrowia z dnia 30 kwietnia 2025 r. zmieniające rozporządzenie w sprawie wykazu substancji psychotropowych, środków odurzających oraz nowych substancji psychoaktywnych, Dz.U. 2025 poz. 598. eli.gov.pl (n.d.). https://eli.gov.pl/eli/DU/2025/598/ogl1
- Rozporządzenie Ministra Zdrowia z dnia 7 lipca 2026 r. zmieniające rozporządzenie w sprawie wykazu substancji psychotropowych, środków odurzających oraz nowych substancji psychoaktywnych, Dz.U. 2026 poz. 934. eli.gov.pl (n.d.). https://eli.gov.pl/eli/DU/2026/934/ogl1
- Roszdravnadzor official card — Government Resolution No. 681 of 30 June 1998 (edition amended 11 June 2025). roszdravnadzor.gov.ru (n.d.). https://roszdravnadzor.gov.ru/spec/drugs/federalcontrol/documents/1671
- Current consolidated text of Government Resolution No. 681 — Roszdravnadzor PDF. roszdravnadzor.gov.ru (n.d.). https://roszdravnadzor.gov.ru/i/upload/images/2026/3/30/1774879151.29078-1-3386659.pdf1
- Federal Law No. 3-FZ, Article 14 — restrictions/prohibition on turnover. consultant.ru (n.d.). https://www.consultant.ru/document/cons_doc_LAW_17437/3edc9648dafb377705b9c4c275a3c943a7f45ae1/1
- Government Resolution No. 1002 of 1 October 2012 — current edition 11 June 2025. consultant.ru (n.d.). https://www.consultant.ru/document/cons_doc_LAW_136206/1
- Government Resolution No. 1002 current List I narcotic quantity table. consultant.ru (n.d.). https://www.consultant.ru/document/cons_doc_LAW_136206/6598ecb6e30274e2fbab0c605a6ebf21250a8eb6/1
- Criminal Code Article 228 — current text (edition 4 August 2026). consultant.ru (n.d.). https://www.consultant.ru/document/cons_doc_LAW_10699/a109722731a0509e104278d1b2d2f589beee330f/1
- Criminal Code Article 228.1 — current text (edition 4 August 2026). consultant.ru (n.d.). https://www.consultant.ru/document/cons_doc_LAW_10699/c6e15d3f1ba69acd08e0639594df466ecdf1958d/1
- Criminal Code Article 229 — current text (edition 4 August 2026). consultant.ru (n.d.). https://www.consultant.ru/document/cons_doc_LAW_10699/8a8770950cc85acf85c3068c02e0d31aea7900d0/1
- Criminal Code Article 229.1 — current text (edition 4 August 2026). consultant.ru (n.d.). https://www.consultant.ru/document/cons_doc_LAW_10699/82872099e82da083817266ed0dfddfda60d45d90/1
- Code of Administrative Offences Article 6.8 — current text (edition 26 July 2026). consultant.ru (n.d.). https://www.consultant.ru/document/cons_doc_LAW_34661/8c58af8ec7516f0ddf1334e950f3a60ea525ca28/1
- Misuse of Drugs Act 1973, First Schedule Part I. sso.agc.gov.sg (n.d.). https://sso.agc.gov.sg/Act/MDA1973?ProvIds=Sc1-1
- 139/1998 Z. z. Act on Narcotic Drugs, Psychotropic Substances and Preparations (consolidated text; time version effective 1 January 2026), Slov-Lex. static.slov-lex.sk (n.d.). https://static.slov-lex.sk/pdf/SK/ZZ/1998/139/ZZ_1998_139_20260101.pdf1
- 139/1998 Z. z. Act on Narcotic Drugs, Psychotropic Substances and Preparations (official Slov-Lex print text; time version effective 1 January 2026). static.slov-lex.sk (n.d.). https://static.slov-lex.sk/static/SK/ZZ/1998/139/20260101.print.html1
- Uredba o razvrstitvi prepovedanih drog (neuradno prečiščeno besedilo št. 6), PISRS. pisrs.si (n.d.). https://pisrs.si/api/datoteke/integracije/4034624951
- Uredba o razvrstitvi prepovedanih drog, Priloga: Seznam skupin prepovedanih drog, PISRS. pisrs.si (n.d.). https://pisrs.si/api/datoteke/integracije/3547986251
- Uredba o spremembi in dopolnitvah Uredbe o razvrstitvi prepovedanih drog, Uradni list RS št. 92/2025. uradni-list.si (n.d.). https://www.uradni-list.si/glasilo-uradni-list-rs/vsebina/2025-01-3240/uredba-o-spremembi-in-dopolnitvah-uredbe-o-razvrstitvi-prepovedanih-drog1
- Enforcement Decree of the Narcotics Control Act, Statutes of the Republic of Korea. elaw.klri.re.kr (n.d.). https://elaw.klri.re.kr/eng_service/lawViewContent.do?hseq=538931
- Real Decreto 2829/1977, consolidated text (last update published 21 April 2026), BOE. boe.es (n.d.). https://www.boe.es/eli/es/rd/1977/10/06/2829/con/202604211
- Förordning (1992:1554) om kontroll av narkotika, Sveriges riksdag. riksdagen.se (n.d.). https://www.riksdagen.se/sv/dokument-och-lagar/dokument/svensk-forfattningssamling/forordning-19921554-om-kontroll-av-narkotika_sfs-1992-1554/1
- Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien (BetmVV-EDI), consolidated text as at 13 March 2026, Fedlex. fedlex.admin.ch (n.d.). https://www.fedlex.admin.ch/filestore/fedlex.data.admin.ch/eli/cc/2011/363/20260313/de/html/fedlex-data-admin-ch-eli-cc-2011-363-20260313-de-html.html1
- Listen und Verzeichnisse, Swissmedic. swissmedic.ch (n.d.). https://www.swissmedic.ch/swissmedic/de/home/services/listen_neu.html1
- Council of Ministers Decision No. 2012/2861, Bazı Maddelerin 2313 Sayılı Uyuşturucu Maddelerin Murakabesi Hakkında Kanun Hükümlerine Tabi Tutulması Hakkında Karar. narkotik.pol.tr (n.d.). https://www.narkotik.pol.tr/kurumlar/narkotik.pol.tr/Arsiv/TUBIM/Documents/TURKIYE%20UYUSTURUCU%20RAPORU%202012.pdf1
- Yeni Nesil Psiko-Aktif Maddeler Sempozyumu (26 November 2013) — Adli Tıp Kurumu. atk.gov.tr (n.d.). https://www.atk.gov.tr/psikoakifmaddeler.pdf1
- Bazı Maddelerin 2313 Sayılı Uyuşturucu Maddelerin Murakabesi Hakkında Kanun Hükümlerine Tabi Tutulması Hakkında Karar (22.03.2012). icisleri.gov.tr (n.d.). https://www.icisleri.gov.tr/bazi-maddelerin-2313-sayili-uyusturucu-maddelerin-murakabesi-hakkinda-kanun-hukumlerine-tabi-tutulmasi-hakkinda-karar-22-03-2012-1
- 2025 Türkiye Uyuşturucu Raporu. narkotik.pol.tr (n.d.). https://www.narkotik.pol.tr/kurumlar/narkotik.pol.tr/Duyurular/2025/10/2025-Uyusturucu-Raporu.pdf1
- Görevlerimiz (08.08.2024) — Narkotik Suçlarla Mücadele Başkanlığı. narkotik.pol.tr (n.d.). https://www.narkotik.pol.tr/gorevlerimiz1
- 5237 Sayılı Türk Ceza Kanunu. alternatifcozumler.adalet.gov.tr (n.d.). https://alternatifcozumler.adalet.gov.tr/Resimler/icon/5237Say%C4%B1l%C4%B1T%C3%BCrkCezaKanunu.pdf1
- Resolution No. 770 of 6 May 2000 — List of narcotic drugs, psychotropic substances and precursors (current consolidated text). zakon.rada.gov.ua (n.d.). https://zakon.rada.gov.ua/laws/show/770-2000-%D0%BF.frame1
- Resolution No. 373 of 31 May 2010 — amendments adding MDPV to the Ukrainian list. zakon.rada.gov.ua (n.d.). https://zakon.rada.gov.ua/laws/show/373-2010-%D0%BF1
- MOH Order No. 188 of 1 August 2000 — tables of small, large and especially large quantities. zakon.rada.gov.ua (n.d.). https://zakon.rada.gov.ua/laws/show/z0512-001
- Criminal Code of Ukraine No. 2341-III — current edition. zakon.rada.gov.ua (n.d.). https://zakon.rada.gov.ua/laws/show/2341-14?lang=uk1
- Federal Decree by Law No. 30 of 2021 on Combating Narcotics and Psychotropic Substances, Schedule 5. uaelegislation.gov.ae (n.d.). https://uaelegislation.gov.ae/en/legislations/1540/regulations/501/download1
- Federal Decree by Law No. (30) of 2021 on Combating Narcotics and Psychotropic Substances — consolidated English text. uaelegislation.gov.ae (n.d.). https://uaelegislation.gov.ae/en/legislations/1540/download1
- Schedule No. (10) — penalties annexed to Federal Decree by Law No. (30) of 2021. uaelegislation.gov.ae (n.d.). https://uaelegislation.gov.ae/en/legislations/1540/regulations/506/download1
- Federal Decree by Law No. (30) of 2021 — official UAE legislation regulation table. uaelegislation.gov.ae (n.d.). https://uaelegislation.gov.ae/en/legislations/1540/regulations1
- Synthetic cathinones: an updated harms assessment (accessible), Advisory Council on the Misuse of Drugs, GOV.UK. gov.uk (n.d.). https://www.gov.uk/government/publications/synthetic-cathinones-an-updated-harms-assessment/synthetic-cathinones-an-updated-harms-assessment-accessible1
- Misuse of Drugs Act 1971 (Amendment) Order 2010, S.I. 2010/1207. legislation.gov.uk (n.d.). https://www.legislation.gov.uk/uksi/2010/1207/pdfs/uksi_20101207_en.pdf1
- Drug Enforcement Administration. (2013-01-04). Establishment of Drug Codes for 26 Substances. Federal Register, 78(3), Article 2012-31698. https://www.govinfo.gov/content/pkg/FR-2013-01-04/html/2012-31698.htm1
Further Reading
Anodyne substance page – MDPV
Anodyne Wiki: 3,4 Methylenedioxy Α Pyrrolidinopentiophenone
Baumann et al. 2013 - Powerful Cocaine-Like Actions of MDPV
Baumann et al. 2017 - Neuropharmacology of MDPV and Related Analogs
Behavioural, Pharmacokinetic, Metabolic and Hyperthermic Profile of MDPV (Frontiers in Psychiatry, 2018)
Coppola & Mondola 2012 - MDPV Chemistry and Pharmacology
Drugs-Forum: MDPV Drug Info Discussion
EMCDDA: 2014 - MDPV Risk Assessment Report
Fantegrossi et al. 2013 - In Vivo Effects of MDPV in Mice
Froberg et al. 2015 - Acute MDPV Toxicity (ToxIC Registry)
Horsley et al. 2018 - Behavioural and Hyperthermic Profile of MDPV
Hyperthermia and multiorgan failure after bath-salts injection (Case Report, 2012)
Intoxications involving MDPV in Sweden 2010-2014
Marinetti & Antonides 2013 - Hyperthermia and Multiorgan Failure After Bath Salts
Marusich et al. 2014 - Pharmacology of MDPV-Related Synthetic Stimulants
Powerful cocaine-like actions of MDPV (Neuropsychopharmacology, 2013)
Saha et al. 2024 - Cardiotoxicity After Synthetic Cathinone Use
Simmler et al. 2017 - Stereoselective Actions of MDPV at Monoamine Transporters
Stereoselective actions of MDPV at monoamine transporters (ACS Chem Neurosci, 2017)
Winstock et al. 2015 - Intoxications Involving MDPV in Sweden 2010-2014
- Reviewed & approved
Reviewed, edited, and approved by subject-matter expert Lyrea.
Automated synthesisInformation aggregated and synthesized using an autonomous workflow built by Josie Kins.
Suggest an edit
Spotted a mistake, an outdated claim, or something missing from the MDPV article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.
Wish to give generalised feedback? You can do so here.