WARNINGMIXING OR WITHDRAWAL CAN BE DANGEROUS
Ordinary doses in combination with other depressants can fatally stop breathing. After prolonged dependency, stopping suddenly can also cause seizures or delirium; seek medical help.
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Halazepam
Halazepam is a benzodiazepine1 depressant with anxiety-reducing, sedative, sleep-inducing, anticonvulsant, and muscle-relaxing effects. It has been prescribed for anxiety.2 It is habit-forming,3 and some clinicians have observed behavioral disinhibition during its use.3
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Pharmacology
Pharmacodynamics
Halazepam positively modulates GABA-A receptors4 through the benzodiazepine binding site, enhancing the action of GABA.4 This promotes chloride channel opening and membrane hyperpolarization, reducing neuronal excitability. Halazepam also modulates the translocator protein.
Pharmacokinetics
Halazepam undergoes hepatic metabolism.5
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Unsafe
AvoidThere is considerable risk of physical harm when taking these combinations, they should be avoided where possible.
Caution
Use cautionThese combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.
Tolerance
Harm Potential
Addiction & Dependence
Psychological
ModerateClassified as habit-forming. Like other benzodiazepines, halazepam carries risk of psychological dependence with regular use.
Physical
ModerateAs a benzodiazepine, physical dependence can develop with chronic use, potentially leading to withdrawal symptoms upon discontinuation.
Toxicity
Adverse effects including drowsiness, confusion, dizziness, and sedation occur at therapeutic and recreational doses; amnesia may be induced at higher doses.
Gastrointestinal side effects including dry mouth and nausea have been reported.
History & Culture
Halazepam was invented in the United States by Schlesinger Walter and was marketed as an anti-anxiety agent in 1981. It was sold under the brand names Paxipam in the United States6, Alapryl in Spain7, and Pacinone in Portugal.…
Legality
By Country
United StatesIllegalReferences
Source Pages
Citations
Further Reading
Article Status
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