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Flutoprazepam

This article is a stubmissing:
Subjective Effects
Tolerance
Legality
Flutoprazepam molecule structureFlutoprazepam molecule structure
7-chloro-1-(cyclopropylmethyl)-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one
Restas, KB-509Open in Piru
Chemical Class
Benzodiazepine

Flutoprazepam is a potent benzodiazepine depressant with sedative, sleep-inducing, anxiety-reducing, and muscle-relaxing effects. It is more potent by weight and longer acting than diazepam. Sumitomo patented it in Japan in 1972, and its medical use remains largely confined to Japan, principally for severe insomnia. Flutoprazepam is habit-forming1 and may cause amnesia and loss of inhibitions when taken in excess. Combining it with other depressants is discouraged.

Dosage & Duration

Log in Piru

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~0.5 mg
Light0.5-1 mg
Moderate1.5-3 mg
Strong3-5 mg
Heavy5+ mg

Duration

Onset15-45 minutes
After Effects24-36 hours
Total12-16 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacokinetics

Flutoprazepam produces long-acting active metabolites that contribute substantially to its pharmacological effects.

Interactions

Dangerous

Highest risk

These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.

AlcoholGHB/GBLOpioidsTramadol

Unsafe

Avoid

There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.

DiphenhydraminePCP

Caution

Use caution

These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.

DXMKetamineMXE
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Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

High

Classified as habit-forming. Benzodiazepines as a class carry significant psychological addiction potential with regular use.

Physical

High

As a benzodiazepine, physical dependence is expected to develop with chronic use, with potentially severe withdrawal symptoms.

History & Culture

Flutoprazepam was patented in Japan by Sumitomo in 1972. Its medical use has remained largely confined to Japan.

Legality

Legality not written up yet

References

Source Pages

  1. Bluelight: Flutoprazepam Discussion Thread
  2. Bluelight: Flutoprazepam or Restas
  3. DrugBank: Flutoprazepam
  4. Erowid Experience: Restas Regret
  5. PsychonautWiki: Benzodiazepines
  6. PsychonautWiki: Dangerous Combinations
  7. TripSit Factsheet: Flutoprazepam
  8. TripSit Factsheet: Norflurazepam
  9. TripSit Wiki: Benzodiazepines
  10. TripSit Wiki: Benzodiazepines
  11. TripSit Wiki: Drug Combinations
  12. TripSit Wiki: Uncommon Benzodiazepines
  13. Wikipedia

Citations

  1. Pharmaceuticals and Medical Devices Safety Information No. 342. Pharmaceuticals and Medical Devices Agency (2017). https://www.pmda.go.jp/files/000217869.pdf1
  2. Pharmacokinetics of flutoprazepam, a novel benzodiazepine drug, in normal subjects. European Journal of Drug Metabolism and Pharmacokinetics (1989). https://doi.org/10.1007/bf0319011412

Further Reading

  1. Drug-Do: Benzos
  2. ScienceDirect: Flutoprazepam Overview
  3. Sukamoto et al. 1980: Psychopharmacological studies of KB-509

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed: this article is pending editorial review by Lyrea.

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