WARNINGMIXING OR WITHDRAWAL CAN BE DANGEROUS
Ordinary doses in combination with other depressants can fatally stop breathing. After prolonged regular use, stopping suddenly can also cause seizures or delirium; seek medical help.
Flunitrazolam
Flunitrazolam is a novel synthetic depressant of the triazolobenzodiazepine class that first emerged on the research chemical market in 2016.1 It has no known precedent in the scientific literature prior to its appearance for sale online.2 Flunitrazolam is notable for its extreme potency, being active in the low microgram range—a characteristic shared with compounds like flubromazolam and clonazolam. As with all benzodiazepines, it carries significant risk of dependence, and its ultra-potent nature makes accurate dosing particularly critical.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
The experience is dominated by powerful sedation, hypnosis, and anxiety relief, consistent with a highly potent triazolobenzodiazepine active at doses as low as 0.1 mg. Its effect profile is broadly comparable to related compounds such as flunitrazepam, clonazolam, and flubromazolam, with a pronounced hypnotic character that readily progresses into sleep at higher doses. Memory of the period following ingestion is frequently impaired or lost entirely, and blackouts are a recognized risk even at seemingly modest amounts given the compound's microgram-level potency.
Physical
Heavy sedation and pronounced muscle relaxation define the body experience, accompanied by a loss of motor coordination that makes movement clumsy and unsteady.
Sedation
Cognitive
The headspace is one of diminished anxiety and mental quieting rather than stimulation or alteration of perception. Anterograde amnesia is a defining feature, with recall of events after dosing often fragmentary or absent, culminating in full blackouts at higher doses.
Suppressions
Pharmacology
Pharmacodynamics
Flunitrazolam acts as a positive allosteric modulator at the GABA-A receptor benzodiazepine binding site, enhancing the inhibitory effects of gamma-aminobutyric acid (GABA). As a triazolobenzodiazepine, it incorporates a fused triazole ring into the benzodiazepine scaffold, which substantially increases potency compared to its parent compound flunitrazepam, rendering it active in the microgram range. The anticonvulsant properties of benzodiazepines may also involve binding to voltage-dependent sodium channels. Very little direct pharmacological research has been conducted on flunitrazolam specifically, and much of its presumed mechanism is inferred from its structural similarity to other benzodiazepines.
Pharmacokinetics
In a self-administration study of Flunitrazolam, the urine was analysed of the volunteer. 7-Amino-Flunitrazolam was detectable for up to 37 hours, Desnitro-Flunitrazolam and 7-Acetamido-Flunitrazolam were also identified. The area response of Desnitro-Flunitrazolam was always lower than compared to the 2 other metabolites and re-analysis showed chemical instability. Hydroxylated forms of Flunitrazolam were not identified in HLMs or urine samples.2
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Unsafe
AvoidThere is considerable risk of physical harm when taking these combinations, they should be avoided where possible.
Caution
Use cautionThese combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Benzodiazepines (all)
Harm Potential
Addiction & Dependence
Psychological
HighHigh abuse potential similar to other potent benzodiazepines.3 Compulsive redosing is commonly reported, and rebound anxiety following use can contribute to cycles of dependence and addiction.4
Physical
Extremely HighExtremely physically addictive with potentially life-threatening withdrawal. Abrupt discontinuation after regular use can result in hypertension, seizures, or death.5 Gradual tapering over weeks is essential; abrupt cessation is dangerous.6
Seizure Risk
Unusually for a benzodiazepine, high to very high doses have reportedly caused seizures without additional triggers such as withdrawal. This proconvulsant effect at high doses is atypical for the drug class. Seizures are also a significant risk during withdrawal from chronic use.6
History & Culture
Flunitrazolam is a novel designer benzodiazepine with no documented history prior to its emergence on the online research chemical market. Unlike many benzodiazepines which were first developed by pharmaceutical companies and later diverted to recreational use, flunitrazolam appears to have been…
Legality
International
The fetched UNODC ICE record identifies Flunitrazolam as a benzodiazepine NPS and shows no international-control schedule entry. A direct text search of the fetched schedules in the official INCB editions of the 1961, 1971 and 1988 conventions found no occurrence of flunitrazolam. This international result does not determine national analogue or generic-law coverage.
By Country
References
Source Pages
Citations
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- Alice Ameline, Camille Richeval, Jean-Michel Gaulier, Jean-Sébastien Raul, & Pascal Kintz. (February 2019). Detection of the designer benzodiazepine flunitrazolam in urine and preliminary data on its metabolism. Drug Testing and Analysis, 11(2), 223–229. https://doi.org/10.1002/dta.2480123
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Further Reading
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