Eutylone
Eutylone is a synthetic psychoactive substance of the substituted cathinone and substituted phenethylamine chemical classes.12 It is classified as both a stimulant and an entactogen, producing a combination of effects that include increased energy and wakefulness alongside enhanced empathy and sociability.2 As a synthetic cathinone, eutylone belongs to a broader family of novel psychoactive substances commonly encountered in research chemical markets.13
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Eutylone produces a primarily stimulating experience with an empathogenic component that is generally described as weaker and less emotionally warm than that of MDMA, for which it has frequently been mis-sold. The effects lean heavily toward physical and mental stimulation, with the entactogenic qualities fading faster than the stimulant ones, leaving a long, wakeful tail. Compulsive redosing is commonly reported as the initial euphoria diminishes.
Physical
Physical effects are dominated by stimulation, including increased heart rate, appetite suppression, and difficulty sleeping that can persist for many hours after the primary effects have subsided.
Stimulation
Uncomfortable
Cognitive
The headspace combines mild euphoria and a muted sense of emotional openness with pronounced mental stimulation. As the experience progresses, the empathogenic warmth tends to give way to a more purely stimulated, sometimes anxious state, and users frequently report a strong urge to redose.
Emotional
Reagent Testing
Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.
Pharmacology
Pharmacodynamics
In rat-brain synaptosome assays, eutylone inhibited uptake at DAT, NET, and SERT. It did not produce efficacious release at DAT or NET, but acted as a partial SERT releasing agent. The investigators therefore characterized eutylone as a hybrid transporter compound: an uptake inhibitor at DAT and NET with substrate-like partial releasing activity at SERT.1
These preclinical assays do not establish a human therapeutic window, safe dose, or receptor-wide binding profile.1
Pharmacokinetics
No controlled human clinical pharmacokinetic study is established here. In pooled human liver microsomes and hepatocytes, eutylone showed slow in-vitro turnover: reported half-lives were 972.5 minutes in microsomes and 375.5 minutes in hepatocytes, with a predicted human hepatic extraction ratio of 0.39. These in-vitro values must not be presented as a human elimination half-life.4 Cross-species hepatocyte work found pronounced species differences, including much faster rat clearance, so rodent disposition should not be directly extrapolated to humans.4
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Substituted cathinones, Stimulants, Entactogens
Harm Potential
Reported adverse effects include insomnia, anxiety, tachycardia, hypertension, hyperthermia, delirium, paranoia, visual hallucinations, rhabdomyolysis, nausea, vomiting, and seizures. Severe toxicity warrants urgent medical attention.5
Addiction & Dependence
Psychological
The WHO review found no animal or human studies of eutylone's dependence potential. It summarized online reports of craving and repeat dosing, but these reports are unconfirmed community evidence and should not be presented as a measured incidence of dependence.5
Toxicity
CDC identified 343 eutylone-involved overdose deaths across 44 participating U.S. jurisdictions in 2020. Most involved other drugs: 77.3% also involved illicitly manufactured fentanyls, and 53.1% involved cocaine or methamphetamine. These surveillance data establish serious risk but do not isolate a eutylone-only lethal dose or causal contribution in each polysubstance death.6 Long-term human outcomes, a toxic dose threshold, and an exposure-response relationship remain unestablished in the reviewed evidence.5
History & Culture
Eutylone was originally developed during the 1960s,1 though it remained obscure for decades before entering recreational drug markets. The compound was first reported to the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) in 2014, marking its…
Legality
International
Eutylone is under international control in Schedule II of the Convention on Psychotropic Substances of 1971. Commission on Narcotic Drugs Decision 65/3 placed it there in March 2022, and the scheduling change took effect on 23 November 2022. The current INCB Green List, 36th edition updated December 2025, identifies eutylone by name, IDS code PE 010, CAS number 802855-66-9 and the chemical name 1-(1,3-Benzodioxol-5-yl)-2-(ethylamino)butan-1-one. INCB's March 2026 supplement adds only MDMB-FUBINACA and does not alter eutylone's Schedule II placement. For Schedule II substances, the Convention directs Parties to limit manufacture, export, import, distribution, stocks, trade, use and possession to medical and scientific purposes and to apply licensing or similar controls. The current Yellow List, 65th edition dated July 2026, and the current Red List contain no eutylone identity match, so the applicable international designation remains psychotropic Schedule II rather than a 1961 Convention narcotic-drug schedule or a 1988 Convention precursor table. These are treaty obligations implemented by Parties, not a universal standalone domestic possession offence, so restricted_other is the applicable canonical status.
By Country
References
Source Pages
Citations
- Eutylone and Its Structural Isomers Interact with Monoamine Transporters and Induce Locomotor Stimulation. ACS Chemical Neuroscience, 12(7), 1170–1177 (April 2021). https://doi.org/10.1021/acschemneuro.0c00797123456
- 1-(1,3-Benzodioxol-5-yl)-2-(ethylamino)butan-1-one (Eutylone) — DEA Drug & Chemical Evaluation. deadiversion.usdoj.gov (n.d.). https://www.deadiversion.usdoj.gov/drug_chem_info/eutylone.pdf1234
- Alex J Krotulski, Donna M Papsun, Chris W Chronister, Joseph Homan, Michele M Crosby, Jennifer Hoyer, Bruce A Goldberger, & Barry K Logan. (August 2020). Eutylone Intoxications-An Emerging Synthetic Stimulant in Forensic Investigations. Journal of Analytical Toxicology, 45(1), 8–20. https://doi.org/10.1093/jat/bkaa1131
- Cross-species metabolic characterization of eutylone and mechanism-based inhibition of CYP2D6 and CYP2B6 with drug interaction implications. pmc.ncbi.nlm.nih.gov (n.d.). https://doi.org/10.1038/s41598-026-48814-7123
- World Health Organization Expert Committee on Drug Dependence. cdn.who.int (n.d.). https://cdn.who.int/media/docs/default-source/essential-medicines/unedited-advance-copy-44th-ecdd-critical-review-report-eutylone.pdf1234
- Notes From the Field: Overdose Deaths Involving Eutylone (Psychoactive Bath Salts) — United States, 2020. (n.d.). https://www.cdc.gov/mmwr/volumes/71/wr/mm7132a3.htm12
- Eutylone (bk-EBDB) and Benzylone (BMDP): Increasing Prevalence of New Synthetic Stimulants in the United States. (n.d.). https://www.cfsre.org/nps-discovery/public-alerts/eutylone-bk-ebdb-and-benzylone-bmdp-increasing-prevalence-of-new-synthetic-stimulants-in-the-united-states12
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