Cognitive fatigue (also called exhaustion, tiredness, lethargy, languidness, languor, lassitude, and listlessness) is medically recognized as a state usually associated with a weakening or depletion of one's mental resources.
[1][2] The intensity and duration of this effect typically depends on the substance consumed and its dosage. It can also be further exacerbated by various factors such as a lack of sleep
[3] or food
[4]. These feelings of exhaustion involve a wide variety of symptoms which generally include some or all of the following effects:
Cognitive fatigue is most commonly induced under the influence of moderate dosages of antipsychotic compounds,[5][6] such as quetiapine, haloperidol, and risperidone. However, it can also occur during the withdrawal symptoms of many depressants[7], and during the offset of many stimulants[8].
