A-PVP
α-PVP is a synthetic stimulant of the cathinone and pyrrolidinophenone classes, chemically related to prolintane and pyrovalerone. Originally patented by Boehringer Ingelheim in the 1960s but never marketed, it emerged as a recreational substance in the early 2010s. Known colloquially as flakka1, α-PVP acts as a norepinephrine-dopamine reuptake inhibitor2, producing powerful but short-lived effects comparable to methamphetamine and cocaine. It has been linked to numerous hospitalizations and deaths, with very limited toxicity data available2.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Effects vary widely by individual, dose, and context.
Physical
Cognitive
The cognitive effects of α-PVP can be broken down into several components which progressively intensify proportional to dosage. The general head space of α-PVP is described by many as one of extreme mental stimulation and powerful euphoria. It contains a large number of typical stimulant cognitive effects.
Pharmacology
Pharmacodynamics
α-PVP acts as a potent and selective norepinephrine-dopamine reuptake inhibitor (NDRI).3 It inhibits dopamine reuptake with IC50 values of 13 to 80 nM and norepinephrine reuptake with IC50 values of 14 to 70 nM, as measured in rat brain synaptosomes and HEK293 cells expressing the monoamine transporters. Notably, α-PVP does not function as a transporter substrate and therefore does not induce neurotransmitter release.3 It has negligible activity at the serotonin transporter.3 In vitro, α-PVP is considerably more potent than amphetamine as an NDRI, showing 46-fold greater potency for dopamine reuptake inhibition and 7-fold greater potency for norepinephrine reuptake inhibition in HEK293 cells, making it one of the most potent dopamine reuptake inhibitors known in vitro.
Pharmacokinetics
Human pharmacokinetic evidence remains limited. In a naturalistic observational study of eight healthy volunteers who self-administered a single 10 mg or 20 mg intranasal dose, mean oral-fluid peak concentration occurred at 60 minutes after 10 mg and 47 minutes after 20 mg. Parent α-PVP and metabolites were recovered mainly in urine collected 2–5 hours after administration. The most abundant identified urinary product was an N-butanoic-acid metabolite formed by oxidative opening of the pyrrolidine ring, including a glucuronide; β-hydroxy-α-PVP was a minor metabolite. Because the study measured oral fluid and urine rather than serial plasma, it does not establish a human plasma half-life or absolute intranasal bioavailability. In non-vaccinated male rats given 0.56–3 mg/kg subcutaneously, serum kinetics were approximately linear and the terminal half-life ranged from 1.82 to 2.54 hours. Apparent distribution volumes of 14.1–17.9 L/kg and measured brain, heart, and kidney concentrations indicated extensive tissue distribution in this animal model. These subcutaneous rat values must not be presented as human or route-independent kinetics; absolute bioavailability was not measured because the study had no intravenous reference dose.
Dangerous
Highest riskThese combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Dopaminergic stimulants
Harm Potential
Addiction & Dependence
Psychological
HighChronic use is considered highly addictive with a high potential for abuse and is capable of causing psychological dependence. Compulsive use patterns are commonly associated with this substance, and when addiction has developed, cravings and withdrawal effects may occur if usage is suddenly stopped.
Toxicity
Due to the potency of its rush, α-PVP can cause various uncomfortable or painful sensations in the heart, especially when abused or used for extended periods; sudden spikes in blood pressure may occur particularly when vaporized or injected.
Psychosis Risk
This compound is known to readily induce psychosis if abused for prolonged periods. Symptoms can easily escalate into frightening delusions, paranoid psychosis, extreme agitation, and other altered mental states.1 In emergency settings, psychosis-like states, agitation, aggression, and hallucinations are commonly observed. Approximately 5-15% of users who develop stimulant psychosis fail to recover completely.
Seizure Risk
α-PVP may lower the seizure threshold in some individuals, especially when abused.
History & Culture
α-PVP (alpha-pyrrolidinovalerophenone) was first described in scientific literature in 1963 and subsequently patented by the pharmaceutical company Boehringer Ingelheim during the 1960s, though it was never developed for medical use or brought to market.…
Legality
International
UN Convention on Psychotropic Substances 1971: scheduled
By Country
References
Citations
- Jiri Patocka, Baoming Zhao, Wei Wu, Blanka Klimova, Martin Valis, Eugenie Nepovimova, & Kamil Kuca. (2020-10-31). Flakka: New Dangerous Synthetic Cathinone on the Drug Scene. International Journal of Molecular Sciences, 21(21), Article 8185. https://doi.org/10.3390/ijms212181851234
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