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These combinations are considered extremely harmful and should always be avoided. Reactions to these drugs taken in combination are highly unpredictable and have a potential to cause death.
There is considerable risk of physical harm when taking these combinations, they should be avoided where possible.
These combinations are not usually physically harmful, but may produce undesirable effects, such as physical discomfort or overstimulation. Extreme use may cause physical health issues. Synergistic effects may be unpredictable. Care should be taken when choosing to use this combination.
Classified as habit-forming, indicating potential for psychological dependence.
Desmethylflunitrazepam was originally identified as an active metabolite of flunitrazepam, the potent benzodiazepine marketed under trade names such as Rohypnol. The compound has since emerged on the grey market as a designer drug, sold online as a research chemical under names including fonazepam and the research designation Ro05-4435.
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