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Yopo

This article is a stubmissing:
Subjective Effects
Pharmacology
Interactions
Tolerance
Harm Potential
Legality
Yopo molecule structureYopo molecule structure
5-Hydroxy-N,N-dimethyltryptamine
Cohoba, Jopo, Parica, Hataj, NiopoOpen in Piru
Psychoactive Class
PsychedelicHallucinogen

Yopo is a plant-derived psychedelic snuff made from the seeds1 of a tree native to the Caribbean and South America.2 Its main active constituent is bufotenin,3 a tryptamine alkaloid,3 with variable trace amounts of DMT and 5-MeO-DMT described as ineffective. It is generally taken by insufflation4 and used in healing ceremonies and rituals.4 Its seeds come from a different species than cebil seeds do.3

Dosage & Duration

Log in Piru

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~3 seeds
Light3-5 seeds
Moderate5-7 seeds
Strong7-10 seeds
Heavy10+ seeds

Duration

Onset0-1 minutes
Peak3-5 minutes
After Effects1-3 hours
Total5-15 minutes

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacology not written up yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Harm Potential not written up yet

History & Culture

Yopo was used in healing ceremonies and rituals.4 Accounts of traditional use described one participant blowing the snuff into another participant's nostril through a long pipe.4

Legality

Legality not written up yet

References

Source Pages

  1. Drug Users Bible by Dominic Milton Trott
  2. Drug Users Bible: Yopo
  3. Erowid: Anadenanthera
  4. Health Canada Drug Status Report: Anadenanthera peregrina
  5. PsychonautWiki: Anadenanthera peregrina
  6. PsychonautWiki: Bufotenin
  7. Wikipedia

Citations

  1. Anadenanthera Speg.. Royal Botanic Gardens, Kew (n.d.). https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:296601-2/general-information1
  2. Anadenanthera peregrina (L.) Speg.. Royal Botanic Gardens, Kew (n.d.). https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:12268-21
  3. Pharmañopo—Psychonautics: Human Intranasal, Sublingual, Intrarectal, Pulmonary and Oral Pharmacology of Bufotenine. Journal of Psychoactive Drugs (2001). https://doi.org/10.1080/02791072.2001.10400574123
  4. Yopo: Basic Info. ICEERS (2025). https://www.iceers.org/en/basic-info/yopo-basic-info1234

Further Reading

  1. Fuller et al. 1995: Tissue distribution and metabolism of bufotenine
  2. Rodd 2002: Snuff synergy with yopo and Banisteriopsis caapi
  3. Torres & Repke 2006: Anadenanthera - Visionary Plant of Ancient South America
  4. Tripsitter Substack: Yopo
  5. Tripsitter: Yopo
  6. McBride 2000 - Bufotenine: Toward an Understanding of Possible Psychoactive Mechanisms
  7. McLeod & Sitaram 1985 - Bufotenine reconsidered

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed: this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

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