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Tiletamine

This article is a stubmissing:
Subjective Effects
Interactions
Tolerance
Legality
Tiletamine molecule structureTiletamine molecule structure
Tiletamine
CI-634, CL-399, CN 54521-2, NSC 167740, TelazolOpen in Piru
Psychoactive Class
Dissociative
Chemical Class
Arylcyclohexylamine

Tiletamine is an arylcyclohexylamine1 dissociative anesthetic1 that is chemically related to ketamine.1 It is used in veterinary medicine alongside zolazepam as an injectable anesthetic for cats and dogs,2 and sometimes with xylazine to immobilize large mammals.3 Tiletamine is relatively uncommon and has been used to adulterate ketamine, where it may cause additional nausea.

Dosage & Duration

Log in Piru

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~2.5 mg
Light2.5-5 mg
Moderate5-10 mg
Strong10-20 mg
Heavy20+ mg

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → orange2
Mecke(ME)
white → green1 → brown1 → brown1 → blue3
Liebermann(LB)
white → orange2
Morr(MO)
pink2 → green1
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Pharmacology

Pharmacodynamics

Tiletamine acts as an NMDA receptor antagonist4, producing dissociative anesthesia.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Tiletamine produced place preference and self-administration in animal experiments.5

History & Culture

Recreational use of Telazol, a veterinary anesthetic containing tiletamine and zolazepam,6 has been documented.6 Tiletamine has also been used as an adulterant in ketamine.

Legality

Legality not written up yet

References

Source Pages

  1. Bluelight: Tiletamine first time trip report
  2. DrugBank: Tiletamine
  3. Erowid: Experience - The strangest trip I've ever had
  4. Erowid: Experience - Trick or treat
  5. Erowid: Tiletamine vault
  6. PsychonautWiki: Disconnective effects
  7. PsychonautWiki: Dissociatives
  8. TripSit: Tiletamine factsheet
  9. Wikipedia

Citations

  1. Dissociative anaesthesia in dogs and cats with use of tiletamine and zolazepam combination. What we already know about it. Polish Journal of Veterinary Sciences (2021). https://doi.org/10.24425/pjvs.2021.138738123
  2. ZOLETIL- tiletamine and zolazepam for injection injection, powder, lyophilized, for solution. DailyMed (2025). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8339b394-4339-422a-b1c9-23bc6b41ba691
  3. Anesthesia of wood bison with medetomidine-zolazepam/tiletamine and xylazine-zolazepam/tiletamine combinations.. The Canadian Veterinary Journal (2000). https://pmc.ncbi.nlm.nih.gov/articles/PMC1476335/1
  4. The abuse liability of the NMDA receptor antagonist-benzodiazepine (tiletamine-zolazepam) combination: evidence from clinical case reports and preclinical studies. Drug Testing and Analysis (2016). https://doi.org/10.1002/dta.19871
  5. Rewarding and reinforcing effects of the NMDA receptor antagonist-benzodiazepine combination, Zoletil®: difference between acute and repeated exposure. PubMed (2012). https://doi.org/10.1016/j.bbr.2012.05.0381
  6. Abuse of telazol: an animal tranquilizer. PubMed (2001). https://doi.org/10.1081/clt-10010516112

Further Reading

  1. Abuse liability of tiletamine–zolazepam (review)
  2. CAHMA: Safer using tiletamine
  3. Cayman Chemical - Tiletamine hydrochloride analytical standard
  4. Drugs-Forum: Tiletamine info and experiences
  5. HKMJ - Abuse of Telazol clinical case report
  6. Pharmacokinetics in polar bears – half-life 1.8 h
  7. PMC Case report: Movement disorder from tiletamine vape abuse
  8. PMC: Comparison of psychopharmacological effects of tiletamine and ketamine in rodents
  9. PubMed: Pharmacokinetics in polar bears (half-life 1.8 h)
  10. Reddit: Tiletamine retrospective review
  11. ScienceDirect: Tiletamine overview and potency vs ketamine
  12. Virbac - Zoletil prescribing information
  13. Zoetis - Telazol full prescribing information

Article Status

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