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Theacrine

This article is a stubmissing:
Subjective Effects
Interactions
History & Culture
Legality
Theacrine molecule structureTheacrine molecule structure
1,3,7,9-Tetramethyluric acid
Teacrine, Temorine, TemurinOpen in Piru
Psychoactive Class
StimulantNootropic
Chemical Class
XanthinePurine alkaloid

Theacrine is a stimulant and nootropic belonging to the xanthine class of purine alkaloids. It occurs naturally in cupuaçu and Chinese kucha tea1 and is structurally similar to caffeine,2 with comparable stimulating effects. It also has anti-inflammatory and analgesic effects. In kucha leaves, theacrine is formed from caffeine through a proposed three-step pathway.3

Dosage & Duration

Log in Piru

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~10 mg
Light10-25 mg
Moderate25-50 mg
Strong50-100 mg
Heavy100+ mg

Duration

Onset15-30 minutes
Total2-6 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacodynamics

Theacrine likely acts as an adenosine receptor antagonist4, although its precise mechanism remains uncertain.5 In animal studies, pretreatment with theacrine reduced the suppression of movement caused by selective A1 and A2A receptor agonists. Experiments with selective D1 and D2 receptor antagonists also indicate that dopamine receptors partly mediate its behavioural effects.

Pharmacokinetics

Theacrine has a reported half-life of 30-33 hours.

Metabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
No evidence of rapid tolerance development was observed in healthy humans taking theacrine daily at doses up to 300 mg/day for eight weeks.

Harm Potential

Addiction & Dependence

Psychological

Theacrine showed no habit-forming effects in healthy humans taking up to 300 mg/day for eight weeks.

Toxicity

Lethal Dosage
SpeciesRouteValue
Animal–810 mg/kg

History & Culture

History & Culture not written up yet

Legality

Legality not written up yet

References

Source Pages

  1. PsychonautWiki: Theacrine
  2. Wikipedia

Citations

  1. Safety of TeaCrine®, a non-habituating, naturally-occurring purine alkaloid over eight weeks of continuous use. Journal of the International Society of Sports Nutrition (2016). https://doi.org/10.1186/s12970-016-0113-31
  2. Assessment of the Drug–Drug Interaction Potential Between Theacrine and Caffeine in Humans. Journal of Caffeine Research (2017). https://doi.org/10.1089/jcr.2017.00061
  3. Theacrine (1,3,7,9-tetramethyluric acid) synthesis in leaves of a Chinese tea, kucha (Camellia assamica var. kucha). Phytochemistry (2002). https://doi.org/10.1016/s0031-9422(02)00086-91
  4. Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: Involvement of adenosine and dopamine receptors. Pharmacology, Biochemistry and Behavior (2012). https://doi.org/10.1016/j.pbb.2012.04.0141
  5. Theacrine From Camellia kucha and Its Health Beneficial Effects. Frontiers in Nutrition (2020). https://doi.org/10.3389/fnut.2020.5968231

Further Reading

  1. He et al. (2017): Assessment of Drug-Drug Interaction Potential Between Theacrine and Caffeine
  2. Kuhman et al. (2015): Cognitive Performance and Mood Following Ingestion of a Theacrine-Containing Dietary Supplement
  3. Nootropics Depot: TeaCrine Guide
  4. RxList: Theacrine Health Benefits and Side Effects
  5. Scientific Reports (2024): Dose Response Effects of Theacrine on Cognitive Performance and Sleep
  6. SelfDecode: 3 Potential Benefits of Theacrine
  7. Wang et al. (2010): Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities
  8. WebMD: Theacrine Overview

Article Status

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    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

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