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Propylphenidate

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Subjective Effects
Pharmacology
Interactions
Tolerance
Propylphenidate molecule structurePropylphenidate molecule structure
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Chemical Class
Phenidate

Propylphenidate is a short-acting stimulant in the phenidate chemical class. It is structurally related to methylphenidate1, with a propyl ester in place of the methyl ester2, and contains a piperidine ring.2 It has been available as a new psychoactive substance3 and is classified as potentially habit-forming.

Dosage & Duration

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Dosage

Doses are population estimates that vary widely between individuals.

Threshold~15 mg
Light15-25 mg
Moderate25-60 mg
Strong60-100 mg
Heavy100+ mg

Duration

Onset15-25 minutes
After Effects1-8 hours
Total1.5-3 hours

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → brown1
Liebermann(LB)
white → orange2
Mecke(ME)
No reaction
No reaction
Mandelin(MD)
No reaction
No reaction
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Pharmacology

Pharmacology not written up yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

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Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Compulsive redosing was perceived as unlikely in an anecdotal account.

Toxicity

Cardiovascular system

Blood pressure measured 152/78 mmHg during use in one anecdotal account.

Upper respiratory tract

Nasal exposure was associated with stinging, persistent nostril discomfort, and a burning sensation as the substance reached the throat.

History & Culture

Propylphenidate was sold as a designer drug before April 2015. A temporary class drug order covering propylphenidate that took effect in the United Kingdom on 10 April 20154 curtailed its availability.

Legality

By Country

Illegal1
United Kingdom flagUnited KingdomIllegal

References

Citations

  1. The Psychonauts’ World of Cognitive Enhancers. Frontiers in Psychiatry (2020). https://doi.org/10.3389/fpsyt.2020.5467961
  2. Regulations Amending the Food and Drug Regulations (Part G — Methylphenidate). Canada Gazette (2017). https://gazette.gc.ca/rp-pr/p2/2017/2017-04-05/html/sor-dors43-eng.html12
  3. Use of cognitive enhancers: methylphenidate and analogs. European Review for Medical and Pharmacological Sciences (2019). https://doi.org/10.26355/eurrev_201901_167411
  4. Circular 015/2015: temporary control of 5 methylphenidate-based NPS. Home Office (2015). https://www.gov.uk/government/publications/circular-0152015-temporary-control-of-5-methylphenidate-based-nps/circular-0152015-temporary-control-of-5-methylphenidate-based-nps1
  5. Misuse of Drugs Act 1971, Schedule 2, Part II, paragraph 1 (latest revised text). legislation.gov.uk (n.d.). https://www.legislation.gov.uk/ukpga/1971/38/schedule/2/part/II/paragraph/11
  6. The Misuse of Drugs Act 1971 (Amendment) Order 2017. legislation.gov.uk (n.d.). https://www.legislation.gov.uk/uksi/2017/634/made1
  7. Misuse of Drugs Act 1971, section 3 (latest revised text). legislation.gov.uk (n.d.). https://www.legislation.gov.uk/ukpga/1971/38/section/31
  8. Misuse of Drugs Act 1971, section 4 (latest revised text). legislation.gov.uk (n.d.). https://www.legislation.gov.uk/ukpga/1971/38/section/41
  9. Misuse of Drugs Act 1971, section 5 (latest revised text). legislation.gov.uk (n.d.). https://www.legislation.gov.uk/ukpga/1971/38/section/51

Further Reading

  1. Luethi et al. 2018 - Pharmacological profile of methylphenidate-based designer drugs

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed: this article is pending editorial review by Lyrea.

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    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

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