Skip to main content
L

Not yet reviewed: this article is pending editorial review by Lyrea.

Citation noticeOur citation system is being overhauled

References and citation markers may currently be incomplete, mismatched, or incorrect. This system is being rebuilt and reviewed before the full site launch.

PRL-8-53

This article is a stubmissing:
Subjective Effects
Interactions
Tolerance
Legality
PRL-8-53 molecule structurePRL-8-53 molecule structure
Open in Piru

PRL-8-53 is a substituted phenethylamine1 with reported nootropic effects on retention of verbal information in humans1, with evidence of this effect coming from a single clinical study. It was first synthesized in the 1970s by medicinal chemistry professor Nikolaus Hansl at Creighton University during his work on amino ethyl meta benzoic acid esters. It reportedly has no recreational value.2

Dosage & Duration

Log in Piru

Dosage

Doses are population estimates that vary widely between individuals.

Threshold2-3 mg
Light3-5 mg
Moderate5-10 mg
Strong10-20 mg
Heavy20+ mg

Starting with a low dose and increasing gradually is strongly recommended due to limited human safety data.

Duration

After Effects1-12 hours

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Liebermann(LB)
white → yellow2
Marquis(MQ)
No reaction
No reaction
Mecke(ME)
No reaction
No reaction
Mandelin(MD)
No reaction
No reaction
Powered by PROtestkit.eu

Pharmacology

Pharmacodynamics

PRL-8-53 has produced a cholinergic response in experimental animals.1 It enhances dopamine activity and partially inhibits serotonin activity,1 although the specific molecular targets are unknown. It also exhibits spasmolytic activity,3 relaxing smooth muscle.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Toxicity

Lethal Dosage

PRL-8-53 is characterized as relatively non-toxic in animal data, with 860 mg/kg reported as the mouse oral LD50.

LD50 Data
SpeciesRouteValue
mouseoral860 mg/kg
cardiovascular

Doses above 8 mg/kg caused brief hypotensive effects in canines.

central nervous system

High doses depressed motor activity in rats and mice; the mouse ED50 for 50% motor reduction was 160 mg/kg.

History & Culture

PRL-8-53 was first synthesized in the 1970s2 by Nikolaus Hansl, a medical chemistry professor at Creighton University, during his research on amino ethyl meta benzoic acid esters. A human study published in 1978 tested PRL-8-53's effects on learning and retention under…

Legality

Legality not written up yet

References

Citations

  1. PRL-8-53: enhanced learning and subsequent retention in humans as a result of low oral doses of new psychotropic agent. Psychopharmacology (full text hosted on Scribd) (1978). https://doi.org/10.1007/bf0043284612345
  2. The Psychonauts’ World of Cognitive Enhancers. Frontiers in Psychiatry (2020). https://doi.org/10.3389/fpsyt.2020.54679612
  3. A novel spasmolytic and CNS active agent: 3-(2-benzylmethylamino ethyl) benzoic acid methyl ester hydrochloride. PubMed (1974). https://doi.org/10.1007/bf019348221
  4. Hansl v. Creighton University. Nebraska Supreme Court / Justia (1993). https://law.justia.com/cases/nebraska/supreme-court/1993/1066-0.html12

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed: this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Suggest an edit

Spotted a mistake, an outdated claim, or something missing from the PRL-8-53 article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.

Wish to give generalised feedback? You can do so here.