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PRE-084

This article is a stubmissing:
Subjective Effects
Interactions
Tolerance
History & Culture
Legality
PRE-084 molecule structurePRE-084 molecule structure
2-Morpholin-4-ylethyl 1-phenylcyclohexanecarboxylate
FenclimorateOpen in Piru
Psychoactive Class
NootropicAntidepressant
Chemical Class
Morpholine derivative

PRE-084 is a morpholine derivative1 structurally related to PCP.2 It exhibits nootropic and antidepressant effects in animal studies, including cognitive enhancement. Animal studies also report reinforcing effects,3 although these findings do not establish its effects in humans.

Dosage & Duration

Log in Piru

Duration

Onset15-30 minutes
Total6-10 hours

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → brown1
Mecke(ME)
white → brown2
Mandelin(MD)
yellow2 → brown2 → brown3
Liebermann(LB)
white → orange2
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Pharmacology

Pharmacodynamics

PRE-084 is a sigma receptor agonist selective for the sigma-1 subtype.4 It also increases the expression of glial cell line-derived neurotrophic factor (GDNF).

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

PRE-084 exhibits reinforcing effects.

History & Culture

History & Culture not written up yet

Legality

Legality not written up yet

References

Source Pages

  1. Bluelight: PRE-084 thread (22 mg sublingual report)
  2. Bluelight: PRE-084 thread (dose-conversion estimate approximately 1.5 mg)
  3. TripSit: Wiki - PRE-084
  4. Wikipedia

Citations

  1. Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand. PubMed (1991). https://pubmed.ncbi.nlm.nih.gov/16583021
  2. PRE-084, a sigma selective PCP derivative, attenuates MK-801-induced impairment of learning in mice. PubMed (1994). https://doi.org/10.1016/0091-3057(94)90235-61
  3. Stimulants as specific inducers of dopamine-independent σ agonist self-administration in rats. Johns Hopkins University (2013). https://doi.org/10.1124/jpet.113.2075221
  4. Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism. Brain (2014). https://doi.org/10.1093/brain/awu1071

Further Reading

  1. Drugs-Forum Drug information: PRE-084
  2. Hong et al., sigma-1 receptor modulation of dopamine transporter (Nature, 2017)
  3. Hong et al., σ-1 receptor modulation of dopamine transporter (Nature, 2017)
  4. Hyrskyluoto et al., Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration
  5. LGC Standards - Chemical structure and IUPAC name for PRE-084
  6. Marra et al., pharmacokinetics of PRE-084 in mice (half-life ≈195 min)
  7. Marra et al., pharmacokinetics of PRE-084 in mice (half-life approximately 195 minutes)
  8. Maurice and Su, The Pharmacology of Sigma-1 Receptors
  9. MedChemExpress: PRE-084 hydrochloride profile
  10. PubChem: compound entry for PRE-084
  11. Reddit: r/Nootropics – Discussion of PRE-084 cognitive effects
  12. Reddit: r/researchchemicals – ‘I have PRE-084!’ (user plans 25-30 mg)
  13. Su et al., Sigma compounds derived from phencyclidine: identification of PRE-084
  14. Tocris - PRE-084 hydrochloride product sheet

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed: this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

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