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Pinazepam

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Subjective Effects
Interactions
Tolerance
History & Culture
Legality
Pinazepam molecule structurePinazepam molecule structure
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Chemical Class
1,4-Benzodiazepine

Pinazepam is a habit-forming1 depressant1 of the 1,4-benzodiazepine class2, used primarily to reduce anxiety. In humans, it is described as producing little significant sedation or impairment of intellectual function and motor coordination compared with typical benzodiazepines. It differs structurally from other benzodiazepines by having a propargyl group at the N-1 position.3

Dosage & Duration

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Dosage

Doses are population estimates that vary widely between individuals.

Threshold~2.5 mg
Light2.5-5 mg
Moderate5-10 mg
Strong10-20 mg
Heavy20+ mg

Duration

Onset15-90 minutes
After Effects2-10 hours
Total6-16 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacokinetics

Pinazepam is rapidly absorbed after oral administration3 and produces two main active metabolites. Pinazepam and one of its active metabolites cross the placenta, although maternal plasma concentrations are usually substantially higher than fetal concentrations. Its elimination half-life is longer in elderly people.

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

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Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Moderate

Pinazepam is considered a habit-forming benzodiazepine depressant.

Toxicity

Lethal Dosage

Combination with all CNS depressants should be avoided. Pinazepam is described as less toxic than diazepam, but no lethal-dose value is provided.

pregnancy and fetal exposure

Pinazepam and N-desmethyldiazepam can reach the fetus during pregnancy.

History & Culture

History & Culture not written up yet

Legality

Legality not written up yet

References

Citations

  1. Domar – Pinazepam: Scheda Tecnica e Prescrivibilità. Torrinomedica (2020). https://www.torrinomedica.it/schede-farmaci/domar12
  2. Toxicological and pharmacological investigations of pinazepam (7-chloro-1-propargyl-5-phenyl-3H-1,4-benzodiazepin-2-one): a new psychotherapeutic agent. Arzneimittelforschung (1975). https://pubmed.ncbi.nlm.nih.gov/2403691
  3. Pinazepam: review of pharmacological properties and therapeutic efficacy. Clinical Therapeutics (1984). https://pubmed.ncbi.nlm.nih.gov/614719212
  4. Metabolic profile of oxazepam and related benzodiazepines: clinical and forensic aspects. PubMed (2017). https://doi.org/10.1080/03602532.2017.13772231

Article Status

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    Step 1 · Automated synthesis

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