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Opium
Opium is a naturally occurring mixture of opiate alkaloids obtained by drying latex from the seed pods of Papaver somniferum. It acts as a depressant1 and pain reliever,2 with morphine as its principal psychoactive constituent.3 Its alkaloid content varies between plants. Ancient civilizations used opium for medicinal and ritual purposes, including pain relief and sedation.4 Opium can cause addiction,2 and long-term use can lead to tolerance, dependence, and increased cancer risk.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Pharmacology
Pharmacodynamics
Opium activates μ-, κ-, and δ-opioid receptors, with its principal psychoactive constituent, morphine, acting at μ-opioid receptors to reduce pain signaling. Activation of these G protein-coupled receptors opens potassium channels and inhibits the opening of voltage-gated calcium channels5, reducing neuronal excitability and neurotransmitter release. Opium also increases smooth muscle tone and reduces gastrointestinal motility.
Pharmacokinetics
Opium has poor oral bioavailability. For opium tincture, reported peak blood concentrations are 16-24 mg/ml, with total exposure (AUC) of 3237-6727 ng/ml.h. Its volume of distribution exceeds total body water, and protein binding varies between alkaloids from 20-60%, principally involving albumin and beta-globulin II. Metabolism includes conversion of opiate constituents to morphine followed by glucuronide conjugation. CYP2D6 contributes to metabolism, and genetic variation in this enzyme can alter the metabolic rate; opium is also listed as a CYP3A and CYP3A4 substrate. The reported half-life is 3-10 hours. Alkaloids are excreted in urine, with detection lasting longer after larger doses or repeated administration.
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Harm Potential
Addiction & Dependence
Toxicity
Opium can cause respiratory depression, hypoventilation, prolonged apnea, respiratory obstruction, pulmonary edema, and respiratory collapse.
Opium can cause cardiac collapse.
Opium can cause coma.
Opium-related endocrine dysfunction can include reduced testosterone, loss of libido, impotence, amenorrhea, and infertility.
Opium can cause constipation, nausea, and vomiting.8
History & Culture
Early cultivation and Mediterranean traditions
The earliest archaeological evidence of human use of opium poppies came from the Mediterranean region and dated to before 5000 BCE. Neolithic finds were reported in Switzerland, Germany, and Spain. At the Cueva de los Murciélagos burial site in Spain, large quantities of poppy capsules were dated…
Legality
International
Prohibited drug of abuse in most countries
Legal production exists in some countries for alkaloid extraction
By Country
References
Citations
Further Reading
Article Status
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