WARNINGMIXING OR WITHDRAWAL CAN BE DANGEROUS
Ordinary doses in combination with other depressants can fatally stop breathing. After prolonged dependency, stopping suddenly can also cause seizures or delirium; seek medical help.
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Nordazepam
Nordazepam is a 1,4-benzodiazepine1 with sedative and anxiolytic effects1, used primarily to treat anxiety disorders. It is an active metabolite of several other benzodiazepines2, including diazepam3, and has one of the longest half-lives in the class. It is habit-forming,4 and its accumulation contributes to cumulative side effects when benzodiazepines that produce it are taken repeatedly at moderate to high doses.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Pharmacology
Pharmacodynamics
Nordazepam acts as a partial agonist at GABA-A receptors.
Pharmacokinetics
Nordazepam undergoes hydroxylation to active metabolites, followed by glucuronide conjugation and urinary excretion. Its elimination half-life ranges from 36 to 200 hours, with substantial variation between individuals related to metabolism, age, sex, and hepatic and renal function. Reduced liver function associated with aging or cirrhosis can impair clearance. Nordazepam readily crosses the placenta5 and is excreted in breast milk.6
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Harm Potential
Addiction & Dependence
Psychological
ModerateNordazepam is considered habit-forming, and benzodiazepines warrant caution in alcohol- or drug-dependent individuals.
Toxicity
Combination with other CNS depressants should be avoided.
Somnolence is common, hypotonia is less common, and fetal exposure late in pregnancy may cause hypothermia, hypotonia, or mild respiratory depression.
Aging, cirrhosis, disease, and variable hepatic or renal metabolic function may impair clearance and contribute to wide half-life variation.
Nordazepam crosses the placenta and is excreted in breast milk; regular intake is described as incompatible with breastfeeding.
History & Culture
Legality
References
Citations
Article Status
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