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Nitrazolam

This article is a stubmissing:
Subjective Effects
Interactions
Tolerance
Legality
Nitrazolam molecule structureNitrazolam molecule structure
Open in Piru

Nitrazolam is a triazolobenzodiazepine1 sold online as a designer drug.2 It is described as a hypnotic depressant with habit-forming potential. Structurally, it differs from clonazolam by the absence of a chlorine group on the benzene ring.2 It is reported to be approximately four times as potent as nitrazepam.

Dosage & Duration

Log in Piru

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~0.5 mg
Light0.5-1 mg
Moderate1-2 mg
Strong2-3 mg
Heavy3+ mg

Duration

Onset15-30 minutes
After Effects2-24 hours
Total5-10 hours

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
No reaction
No reaction
Mecke(ME)
No reaction
No reaction
Mandelin(MD)
No reaction
No reaction
Liebermann(LB)
No reaction
No reaction
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Pharmacology

Pharmacodynamics

In a mouse study, nitrazolam prevented electroshock-induced tonic-extensor convulsions with several times the potency of diazepam, but was less potent than diazepam at suppressing the righting reflex.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Nitrazolam has habit-forming potential.

Seizure Risk

In a mouse study, nitrazolam was several times more potent than diazepam at suppressing electroshock-induced tonic-extensor convulsions.

History & Culture

Nitrazolam was sold online as a designer drug.2 It was also used as an example compound in a demonstration of microscale reference-material synthesis using polymer-supported reagents.2

Legality

Legality not written up yet

References

Citations

  1. ‘New/Designer Benzodiazepines’: An Analysis of the Literature and Psychonauts’ Trip Reports. University of Hertfordshire Research Archive (2020). https://uhra.herts.ac.uk/id/document/99391
  2. An approach to shortening the timeframe between the emergence of new compounds on the drugs market and the availability of reference standards: The microscale syntheses of nitrazolam and clonazolam for use as reference materials, utilizing polymer-supported reagents. PubMed (2018). https://doi.org/10.1002/dta.23831234

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed: this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

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