Citation noticeOur citation system is being overhauled
References and citation markers may currently be incomplete, mismatched, or incorrect. This system is being rebuilt and reviewed before the full site launch.
Nefiracetam
Nefiracetam is a nootropic compound1 of the racetam family that is fat soluble. It is suggested to have neuroprotective effects with long-term use, and preliminary research in rats suggests that it may have antidementia properties.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
The total daily amount is typically divided into three separate doses. Weight-based dosing generally falls in the range of 0.5 to 1.6 mg per kilogram of body weight.
Duration
Subjective Effects
Pharmacology
Pharmacodynamics
Nefiracetam enhances GABAergic, cholinergic, and monoaminergic neuronal signaling, which mediates its cytoprotective actions. Despite noting failure to displace 20% of specifically bound muscimol in receptor competition studies, a review describes nefiracetam as having high affinity for GABA-A receptors,2 where it is presumed to act as an agonist. In binding experiments, it inhibited 80% of muscimol binding but did not displace the remaining 20% of specific binding.2
Pharmacokinetics
Nefiracetam is fat soluble. Its metabolism differs between species, with dogs producing a metabolite that is not formed in humans.
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Harm Potential
Toxicity
Nefiracetam can cause renal toxicity in animals whose metabolism differs from that of humans and primates, with dogs particularly susceptible.
Nefiracetam causes testicular toxicity in dogs and rats3, with rats requiring higher doses than dogs to produce this damage.
History & Culture
Legality
References
Citations
Article Status
Step 1 · Automated synthesisAn autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.
- Step 2 · First-pass reviewPending
Not yet reviewed: this article is pending editorial review by Lyrea.
- Step 3 · Citation reviewPending
No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.
Suggest an edit
Spotted a mistake, an outdated claim, or something missing from the Nefiracetam article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.
Wish to give generalised feedback? You can do so here.
