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Methamnetamine

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Subjective Effects
Interactions
Tolerance
Methamnetamine molecule structureMethamnetamine molecule structure
Open in Piru
Chemical Class
Amphetamine

Methamnetamine is a psychoactive substance1 in the amphetamine and naphthylaminopropane families with reported mild psychedelic activity. It is a structural analog of methamphetamine1 and is commonly taken with a stimulant for euphoric effects. Its effects are anticipated to last around five hours. It was sold online as a designer drug between 2015 and 2016.

Dosage & Duration

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Dosage

Doses are population estimates that vary widely between individuals.

Threshold~60 mg
Light60-80 mg
Moderate80-120 mg
Strong120-150 mg
Heavy150+ mg

Duration

Onset10-30 minutes
After Effects1-6 hours
Total3-6 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacodynamics

Methamnetamine promotes the release of serotonin, norepinephrine, and dopamine1, with reported EC50 values of 13 nM, 34 nM, and 10 nM, respectively. It also acts as a lower-potency partial agonist at the 5-HT2A receptor.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Methamnetamine has habit-forming potential.

History & Culture

Methamnetamine was sold online as a designer drug between 2015 and 2016. It first appeared through a small number of online vendors at the start of 2015 but did not gain significant popularity. Its availability in the United Kingdom continued until the passage of the Psychoactive Substances Act in May 2016, which curtailed opportunities for further use.

Legality

By Country

Illegal1
United Kingdom flagUnited KingdomIllegal (analog/blanket ban)

References

Citations

  1. Swedish Prosecution Authority — Metamnetamin substance assessment. aklagare.se (n.d.). https://www.aklagare.se/globalassets/dokument/narkotikapreparat/m/metamnetamin.pdf1234
  2. FDA UNII Search Service — Methamnetamine (UNII CAS64BB01B). precision.fda.gov (n.d.). https://precision.fda.gov/uniisearch/srs/unii/cas64bb01b1
  3. Psychoactive Substances Act 2016, section 2 — Meaning of psychoactive substance. legislation.gov.uk (n.d.). https://www.legislation.gov.uk/ukpga/2016/2/section/21
  4. Home Office — Psychoactive Substances Act 2016: Forensic Strategy. assets.publishing.service.gov.uk (n.d.). https://assets.publishing.service.gov.uk/media/5a819d5ee5274a2e8ab54f0f/psychoactive-substances-act-forensic-strategy.docx1
  5. ACMD's final advice on definitions for the Psychoactive Substances Bill. assets.publishing.service.gov.uk (n.d.). https://assets.publishing.service.gov.uk/media/5a7f1ee5e5274a2e87db3ebd/ACMD_definitions_advice_final-23-October-2015.pdf1
  6. Studies of the Biogenic Amine Transporters. 14. Identification of Low-Efficacy Partial Substrates for the Biogenic Amine Transporters. pmc.ncbi.nlm.nih.gov (n.d.). https://pmc.ncbi.nlm.nih.gov/articles/PMC3364510/1
  7. Assessment of the abuse potential of methamnetamine in rodents: a behavioral pharmacology study. pubmed.ncbi.nlm.nih.gov (n.d.). https://pubmed.ncbi.nlm.nih.gov/33811503/1
  8. Report on the Home Office Forensic Early Warning System (FEWS) — 2015/16. assets.publishing.service.gov.uk (n.d.). https://assets.publishing.service.gov.uk/media/5beee9b2ed915d1813d80e58/FEWS_annual_report_2015_16_Final.pdf1
  9. Misuse of Drugs Act 1971, current revised Schedule 2. legislation.gov.uk (n.d.). https://www.legislation.gov.uk/ukpga/1971/38/schedule/21
  10. Psychoactive Substances Act 2016, current revised body. legislation.gov.uk (n.d.). https://www.legislation.gov.uk/ukpga/2016/2/body1

Further Reading

  1. Rothman et al. 2012 - Studies of the Biogenic Amine Transporters. 14. Identification of Low-Efficacy “Partial” Substrates for the Biogenic Amine Transporters

Article Status

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    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

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