Methallylescaline
Methallylescaline (MAL) is a synthetic1 psychedelic1 of the substituted phenethylamine class and a structural analog of mescaline.2 Its effects were first described by Alexander Shulgin in PiHKAL, with anecdotal reports suggesting it most closely resembles mescaline among the various mescaline analogs, producing both hallucinogenic and stimulant2 properties. Very little data exists regarding its pharmacology, metabolism, or toxicity,3 and it has minimal history of human use.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Methallylescaline has a steep dose-response relationship, meaning relatively small increases in the amount taken may result in disproportionately stronger effects. Careful attention to precise dosing is advisable.
Duration
Subjective Effects
Effects vary widely by individual, dose, and context.
Physical
Cognitive
Visual
Hallucinatory States
Auditory
Pharmacology
Pharmacodynamics
Methallylescaline acts as an agonist at serotonin 5-HT2 receptors,4 with primary activity at the 5-HT2A receptor. It has been described both as a potent 5-HT2A agonist4 and as a likely 5-HT2A partial agonist. It also interacts with the 5-HT2C receptor.4
Pharmacokinetics
The metabolism of Methallylescaline has been studied. Methallylescaline is proposed to undergo hydroxylation, O-dealkylation, carboxylation, deamination and dihydroxylation of the allyl group.2
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Psychedelics
Harm Potential
Addiction & Dependence
Psychological
Extremely LowMethallylescaline is not habit-forming, and the desire to use it can actually decrease with use. It is most often self-regulating.
Psychosis Risk
Delusion is listed among possible cognitive effects. Some reports mention experiences described as 'shades of what might become amnesia' and 'losing immediate contact,' though formal psychosis risk has not been evaluated due to the substance's limited research history.2
History & Culture
Methallylescaline was first synthesized and explored by American chemist Alexander Shulgin, who initially experimented with the compound in 1981. The following year, in 1982, Shulgin discovered its hallucinogenic properties. He subsequently documented his findings in his 1991 book PiHKAL: A…
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Legality
By Country
References
Citations
- Alexander Shulgin, & Ann Shulgin. (1991). PiHKAL #99: MAL. https://www.erowid.org/library/books_online/pihkal/pihkal099.shtml1234
- Tang Y, Xu L, Guo Z, Zhao J, Xiao Y, Xiang P, & Yan H. (2025). Metabolism study of two phenethylamine-derived new psychoactive substances using in silico, in vivo, and in vitro approaches. 99(6), 2367-2378. https://doi.org/10.1007/s00204-025-04010-61234
- Sunjoo Kim, Ju Hyun Kim, Dong Kyun Kim, Jaesin Lee, Sangwhan In, & Hye Suklee. (2018). In vitro metabolism of methallylescaline in human hepatocytes using liquid chromatography-high resolution mass spectrometry. 9(3), 86-90. https://doi.org/10.5478/msl.2018.9.3.861
- Karolina E. Kolaczynska, Dino Luethi, Daniel Trachsel, Marius C. Hoener, & Matthias E. Liechti. (2022). Receptor Interaction Profiles of 4-Alkoxy-3,5-Dimethoxy-Phenethylamines (Mescaline Derivatives) and Related Amphetamines. 12, Article 794254. https://doi.org/10.3389/fphar.2021.79425412345
- L. A. King. (2013). Shulgin A, Shulgin A (September 1991). PiHKAL: A Chemical Love Story. https://doi.org/10.1002/dta.15701
- Controlled Drugs and Substances Act (current consolidated full text). laws-lois.justice.gc.ca (n.d.). https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html1
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- NIH PubChem CID 44350127 synonyms. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/44350127/synonyms/JSON12345
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- Health Canada DPD API active-ingredient query: methallylescaline. health-products.canada.ca (n.d.). https://health-products.canada.ca/api/drug/activeingredient/?ingredientname=methallylescaline&lang=en&type=json1
- Health Canada DPD API active-ingredient query: 4-methallyloxy-3,5-dimethoxyphenethylamine. health-products.canada.ca (n.d.). https://health-products.canada.ca/api/drug/activeingredient/?ingredientname=4-methallyloxy-3%2C5-dimethoxyphenethylamine&lang=en&type=json1
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- BtMG Anlage I (zu § 1 Abs. 1), nicht verkehrsfähige Betäubungsmittel. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/btmg_1981/anlage_i.html12
- NIH PubChem compound properties for Methallylescaline. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/name/methallylescaline/property/Title,IUPACName,CanonicalSMILES,IsomericSMILES/JSON12
- Betäubungsmittelgesetz (BtMG), § 1. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/btmg_1981/BJNR106810981.html1
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- BetmVV-EDI, Annex 6 Verzeichnis e item 149 Methallylescalin, consolidated stand 13 March 2026. fedlex.admin.ch (n.d.). https://www.fedlex.admin.ch/filestore/fedlex.data.admin.ch/eli/cc/2011/363/20260313/de/pdf-a/fedlex-data-admin-ch-eli-cc-2011-363-20260313-de-pdf-a-3.pdf12
- NIH PubChem compound properties for Methallylescaline. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/name/methallylescaline/property/Title,IUPACName,CanonicalSMILES,IsomericSMILES,MolecularFormula/JSON12
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