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Meclofenoxate

This article is a stubmissing:
Subjective Effects
Interactions
Tolerance
Meclofenoxate molecule structureMeclofenoxate molecule structure
2-Dimethylaminoethyl (4-chlorophenoxy)acetate
Centrophenoxine, Lucidril, Helfergin, ANP 235Open in Piru
Psychoactive Class
Nootropic
Chemical Class
Choline derivative

Meclofenoxate is classified as a nootropic agent1 used as a dietary supplement.2 Chemically, it is an ester of dimethylethanolamine and 4-chlorophenoxyacetic acid.1 It improves performance on certain memory tests in elderly patients, although this finding does not establish broader cognitive benefits.

Dosage & Duration

Log in Piru

Dosage

Doses are population estimates that vary widely between individuals.

Threshold50 mg
Light50-200 mg
Moderate400-800 mg
Strong800-1000 mg
Heavy600+ mg

Duration

Total4-8 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacodynamics

Meclofenoxate increases cellular membrane phospholipids. In vitro studies in rat brain tissue also show inhibition of monoamine oxidase, including both MAO-A and MAO-B.

Pharmacokinetics

A portion of meclofenoxate breaks down into two metabolites, one of which is subsequently converted to choline.

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

Meclofenoxate is considered non-addictive with no documented abuse potential or reinforcing properties.

Physical

Extremely Low

No physical dependence or withdrawal symptoms have been reported.

Seizure Risk

Meclofenoxate is contraindicated in individuals with epilepsy or a history of convulsions, suggesting potential seizure threshold effects, though specific risk data is not characterized.

History & Culture

Meclofenoxate was developed in 1959 at the French National Scientific Research Center.4 It was subsequently tested as a potential treatment for Alzheimer's disease.5…

Legality

By Country

Not scheduled1
United States flagUnited StatesNot scheduled

References

Source Pages

  1. Erowid
  2. Erowid: Meclofenoxate Vault
  3. Isomer Design (TiHKAL/PiHKAL)
  4. Meclofenoxate DrugBank Entry
  5. PsychonautWiki
  6. TripSit Factsheets
  7. Wikipedia

Citations

  1. Meclofenoxate — MeSH. National Library of Medicine (n.d.). https://www.ncbi.nlm.nih.gov/mesh/6800250412
  2. What Do Athletes Need to Know About Meclofenoxate?. U.S. Anti-Doping Agency (n.d.). https://www.usada.org/spirit-of-sport/athletes-need-know-meclofenoxate1
  3. Comparative Studies on the Metabolism of β-Dimethylaminoethanol in the Mouse Brain and Liver Following Administration of β-Dimethyl-aminoethanol and Its p-Chlorophenoxyacetate, Meclofenoxate. Chemical and Pharmaceutical Bulletin (1976). https://doi.org/10.1248/cpb.24.7631
  4. New Phenoxyacetic Acid Analogues with Antimicrobial Activity. Revista de Chimie (2008). https://pdfs.semanticscholar.org/6bfc/ed35257094db70f6c5b4e2829854a5a467c6.pdf1
  5. The effects of meclofenoxate on cognitive performance in elderly individuals with memory impairment: A placebo-controlled study. International Journal of Geriatric Psychiatry (1986). https://doi.org/10.1002/gps.9300102041
  6. Lucidril (International). Drugs.com (n.d.). https://www.drugs.com/international/lucidril.html1
  7. The unapproved drug centrophenoxine (meclofenoxate) in cognitive enhancement dietary supplements. Clinical Toxicology (2022). https://doi.org/10.1080/15563650.2022.21094851
  8. MECLOFENOXATE HYDROCHLORIDE — UNII 5BK3070BDY. precision.fda.gov (n.d.). https://precision.fda.gov/uniisearch/srs/unii/5BK3070BDY1
  9. 21 C.F.R. Part 1308—Schedules of Controlled Substances (2025 annual edition). govinfo.gov (n.d.). https://www.govinfo.gov/content/pkg/CFR-2025-title21-vol9/xml/CFR-2025-title21-vol9-part1308.xml1
  10. Controlled Substances—Alphabetical Order. deadiversion.usdoj.gov (n.d.). https://www.deadiversion.usdoj.gov/schedules/orangebook/c_cs_alpha.pdf1

Further Reading

  1. Alzheimer's Drug Discovery Foundation: Centrophenoxine Review
  2. Hochschild 1973: Effect on lifespan in mice
  3. Malík & Tlustoš 2022: Nootropics as Cognitive Enhancers
  4. Nootropics Expert: Centrophenoxine
  5. SelfHacked: Centrophenoxine Guide
  6. Stancheva & Alova: MAO inhibition study
  7. Vinmec: Uses of Lucimax

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed: this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

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