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Mdphp

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Subjective Effects
Interactions
Tolerance
Legality
Mdphp molecule structureMdphp molecule structure
Open in Piru
Chemical Class
Pyrrolidinophenone

MDPHP is a stimulant1 in the pyrrolidinophenone class of cathinones, structurally related to α-PVP, α-PHP, and MDPV.2 It appeared primarily in Europe in the mid-2010s and has a limited history of use. Reports suggest that batches vary in purity and composition, with other cathinones sometimes sold as MDPHP, making its effects less predictable. Its unpleasant taste can occasionally cause nausea.

Dosage & Duration

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Dosage

Doses are population estimates that vary widely between individuals.

Threshold~10 mg
Light10-20 mg
Moderate20-40 mg
Strong40+ mg

Duration

Onset30-60 minutes
Total3-6 hours

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → yellow2
Mecke(ME)
white → yellow2 → orange2
Mandelin(MD)
yellow2 → green2 → brown2
Liebermann(LB)
white → black3
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Pharmacology

Pharmacodynamics

MDPHP is thought to inhibit dopamine and norepinephrine reuptake, based on its reported effects and structural similarity to studied cathinones and pyrovalerones. A serotonergic component has also been suggested, but these proposed mechanisms have not been established by formal pharmacological studies.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Moderate

While seemingly less compulsive than related cathinones like α-PHP and MDPV, users can still become trapped in cycles of chasing progressively shorter-lasting euphoria and avoiding the comedown. Some users report compulsive redosing patterns despite the drug not being particularly euphoric, with the short-lasting positive effects and undesirable comedown driving continued use.

Toxicity

Lethal Dosage

No fatalities have been reported, although fatal toxicity is believed possible with overdose. One case of fetal death was temporally linked to MDPHP and α-PHP use in a pregnant female, though the exact cause of the intrauterine asphyxia was not determined.

Cardiovascular

Increased heart rate and blood pressure occur commonly during use; overdose could cause excessively elevated cardiovascular parameters, with complications such as myocardial infarction and stroke considered possible though not yet documented in medical case reports.

Psychosis Risk

Moderate

Stimulant psychosis is possible with high doses, prolonged use, and sleep deprivation, but is not the typical effect at reasonable doses with adequate sleep. Case reports have documented psychosis and aggressiveness requiring police assistance. Nearly all severe experiences reported involve prolonged use over 1-2 days with little to no sleep. The psychological and cognitive negatives are significantly increased with multiple doses and sleep deprivation.

Seizure Risk

Low

Overdose carries an increased risk of seizure, though no specific case reports describing MDPHP-induced seizures have been published.

History & Culture

MDPHP appears to have been synthesized around 1960, but its use emerged primarily in Europe in the mid-2010s. It was sold through the research chemical market as an alternative to cathinones such as α-PVP and MDPV, with greater popularity in some European countries, including Poland, than in North…

Legality

Legality not written up yet

References

Citations

  1. Drug Primer: MDPHP. Axis Forensic Toxicology (2026). https://axisfortox.com/drug-primer-mdphp1
  2. Synthetic cathinones: an updated harms assessment (accessible). Advisory Council on the Misuse of Drugs (2025). https://www.gov.uk/government/publications/synthetic-cathinones-an-updated-harms-assessment/synthetic-cathinones-an-updated-harms-assessment-accessible1
  3. EMCDDA–Europol 2014 Annual Report. EMCDDA and Europol (2015). https://www.euda.europa.eu/system/files/publications/1018/TDAN15001ENN.pdf1
  4. 'Zombies', 'cannibals', and 'super humans': a quantitative and qualitative analysis of UK news media reporting of the cathinone psychostimulants labelled 'monkey dust'. LJMU Research Online (2020). https://doi.org/10.1080/09687637.2020.179994412

Article Status

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