Skip to main content
L

Not yet reviewed: this article is pending editorial review by Lyrea.

Citation noticeOur citation system is being overhauled

References and citation markers may currently be incomplete, mismatched, or incorrect. This system is being rebuilt and reviewed before the full site launch.

Mdoh

This article is a stubmissing:
Subjective Effects
Interactions
Tolerance
Legality
Mdoh molecule structureMdoh molecule structure
Open in Piru
Chemical Class
MDxx

MDOH is an entactogen, psychedelic, and stimulant in the phenethylamine and amphetamine chemical classes. It is an analogue of MDA distinguished by an N-hydroxy group1 and is described as having strongly psychedelic effects. It was first synthesised by Alexander Shulgin and has not seen widespread use. Reported adverse effects include urinary retention and a pronounced comedown.

Dosage & Duration

Log in Piru

Dosage

Doses are population estimates that vary widely between individuals.

Threshold80 mg
Light100-120 mg
Moderate120-150 mg
Heavy150+ mg

Duration

Onset20-40 minutes
After Effects1-6 hours
Total4-6 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacodynamics

MDOH is suspected to act as a serotonin releasing agent.

Pharmacokinetics

Metabolic interconversion between MDOH and a related compound has been proposed, but remains unconfirmed. Both removal and addition of the N-hydroxy oxygen have been suggested as possible pathways.2

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Toxicity

Urinary system

MDOH has been reported to cause difficulty urinating and urinary retention.

History & Culture

MDOH was first synthesized by Alexander Shulgin. Its use remained limited and did not become widespread.

Legality

Legality not written up yet

References

Citations

  1. The Characterization of Some 3,4-Methylenedioxyphenylisopropylamine (MDA) Analogs. Journal of Forensic Sciences; full-text transcription hosted by Rhodium (1989). https://chemistry.mdma.ch/hiveboard/rhodium/mda.analogs.characterization.html1
  2. PiHKAL: A Chemical Love Story, #114 MDOH. Erowid (1991). https://erowid.org/library/books_online/pihkal/pihkal114.shtml1
  3. PiHKAL: A Chemical Love Story — #114 MDOH. Transform Press (text hosted by The Vespiary) (1991). https://www.thevespiary.org/library/Files_Uploaded_by_Users/llamabox/PiHKAL.pdf1

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed: this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Suggest an edit

Spotted a mistake, an outdated claim, or something missing from the Mdoh article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.

Wish to give generalised feedback? You can do so here.