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LAE-32

This article is a stubmissing:
Subjective Effects
Interactions
Tolerance
LAE-32 molecule structureLAE-32 molecule structure
Open in Piru
Chemical Class
Lysergamide

LAE-32 is a semisynthetic psychedelic of the lysergamide class related to LSD. It is described as an LSD analogue that is weaker and shorter-lasting than LSD.1 Albert Hofmann and colleagues first described it in the scientific literature by 1955. It was studied in the CIA's Project MKULTRA and in psychedelic-assisted psychotherapy. Historical CIA documents suggest that it can cause a schizophrenia-like condition.

Dosage & Duration

Log in Piru

Dosage

Doses are population estimates that vary widely between individuals.

Moderate500-1500 µg

Duration

Total4-10 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacodynamics

LAE-32 most likely acts by binding to serotonin receptors in the brain. It may also bind to dopamine receptors.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Psychosis Risk

LAE-32 has been reported to induce a schizophrenia-like condition characterized by depersonalization and indifference in mentally healthy individuals. The substance's primary psychological effects appear to involve significant dissociative and depersonalizing states that resemble psychotic symptomatology.

History & Culture

LAE-32 was described in the scientific literature by Albert Hofmann and colleagues by 1955. The CIA studied LAE-32 as part of Project MKULTRA.2 CIA documents released…

Legality

International

The quoted legal-status section does not identify any nation where LAE-32 is directly banned.

By Country

Illegal1
United States flagUnited StatesIllegal (analog/blanket ban)

References

Citations

  1. Psychedelic treatment of functional neurological disorder: a systematic review. Therapeutic Advances in Psychopharmacology (2020). https://doi.org/10.1177/204512532091212512
  2. MKULTRA Briefing Book: DOC_0000190090. Central Intelligence Agency records reproduced by The Black Vault (n.d.). https://documents.theblackvault.com/documents/mkultra/MKULTRA2/DOC_0000190090/DOC_0000190090.pdf1
  3. PubChem PUG REST — D-Lysergic acid monoethylamide synonyms (CID 101704). pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/101704/synonyms/JSON1
  4. PubChem PUG REST — Lysergic acid ethylamide properties (CID 12304966). pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/12304966/property/Title,IUPACName,MolecularFormula,IsomericSMILES,CanonicalSMILES/JSON1
  5. PubChem PUG REST — (+)-Lysergic acid diethylamide properties (CID 5761). pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/5761/property/Title,IUPACName,MolecularFormula,IsomericSMILES,CanonicalSMILES/JSON1
  6. The inhibitory effect of methergoline on LAE-32-induced head-twitches in mice. pubmed.ncbi.nlm.nih.gov (n.d.). https://pubmed.ncbi.nlm.nih.gov/19604948/1
  7. Lists of Scheduling Actions, Controlled Substances, Regulated Chemicals — August 2026. deadiversion.usdoj.gov (n.d.). https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf1
  8. 2025 Code of Federal Regulations, Title 21, Part 1308 — Schedules of Controlled Substances. govinfo.gov (n.d.). https://www.govinfo.gov/content/pkg/CFR-2025-title21-vol9/xml/CFR-2025-title21-vol9-part1308.xml1
  9. DEA Diversion Control Division — Controlled Substance Schedules. deadiversion.usdoj.gov (n.d.). https://www.deadiversion.usdoj.gov/schedules/schedules.html1
  10. 21 U.S.C. § 802 — Definitions. uscode.house.gov (n.d.). https://uscode.house.gov/view.xhtml?req=granuleid:USC-prelim-title21-section802&num=0&edition=prelim1

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

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