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HOT-2

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Subjective Effects
Interactions
Tolerance
HOT-2 molecule structureHOT-2 molecule structure
Open in Piru
Chemical Class
2C-X

HOT-2 is a psychedelic phenethylamine belonging to the 2C-X and HOT families. It is the N-hydroxy derivative of 2C-T-21 and is described as a stimulating psychedelic. Alexander Shulgin synthesized HOT-2 and first described it in the literature in his 1991 book PiHKAL.

Dosage & Duration

Log in Piru

Dosage

Doses are population estimates that vary widely between individuals.

Threshold8 mg
Light10-12 mg
Moderate10-18 mg
Strong15-18 mg
Heavy18+ mg

Duration

Onset20-40 minutes
After Effects1-12 hours
Total5-12 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacokinetics

HOT-2 may act as a prodrug, meaning it may be converted in the body into an active substance.

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Toxicity

Cardiovascular

Acute cardiovascular effects including elevated blood pressure and increased heart rate occur during intoxication; blood pressure elevations were noted to return to normal relatively quickly in documented experiences.

Psychosis Risk

Mental confusion and difficulty concentrating have been reported during intoxication. Psychological discomfort and difficulty communicating were noted in some experiences.

History & Culture

Alexander Shulgin first described HOT-2 in the literature in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved). Its use remained rare, with very few subsequent reports and no reported sale on the market.

Legality

By Country

Illegal1
United States flagUnited StatesIllegal (analog/blanket ban)

References

Citations

  1. PiHKAL — #81 FLEA. Transform Press; primary book text archived by Erowid (1991). https://www.erowid.org/library/books_online/pihkal/pihkal081.shtml1
  2. Solicitation of Information on the Use of Phenethylamine-Related Compounds, 71 Fed. Reg. 62017. govinfo.gov (n.d.). https://www.govinfo.gov/content/pkg/FR-2006-10-20/pdf/E6-17523.pdf1
  3. Lists of Scheduling Actions, Controlled Substances, Regulated Chemicals — August 2026. deadiversion.usdoj.gov (n.d.). https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf1
  4. DEA Diversion Control Division — Controlled Substance Schedules. deadiversion.usdoj.gov (n.d.). https://www.deadiversion.usdoj.gov/schedules/schedules.html1
  5. 21 U.S.C. § 802 — Definitions. uscode.house.gov (n.d.). https://uscode.house.gov/view.xhtml?req=granuleid:USC-prelim-title21-section802&num=0&edition=prelim1
  6. 21 U.S.C. § 813 — Treatment of controlled substance analogues. uscode.house.gov (n.d.). https://uscode.house.gov/view.xhtml?req=granuleid:USC-prelim-title21-section813&num=0&edition=prelim1
  7. 21 U.S.C. § 841 — Prohibited acts A. uscode.house.gov (n.d.). https://uscode.house.gov/view.xhtml?req=granuleid:USC-prelim-title21-section841&num=0&edition=prelim1
  8. 21 U.S.C. § 844 — Penalties for simple possession. uscode.house.gov (n.d.). https://uscode.house.gov/view.xhtml?req=granuleid:USC-prelim-title21-section844&num=0&edition=prelim1

Article Status

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