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HDEP-28

This article is a stubmissing:
Subjective Effects
Interactions
Tolerance
Legality
HDEP-28 molecule structureHDEP-28 molecule structure
Open in Piru
Chemical Class
Phenidate

HDEP-28 is a stimulant of the phenidate chemical class.1 Its structure resembles ethylphenidate but contains a naphthalene ring in place of the benzene ring,2 and it is more closely related to HDMP-28. It has been sold as a designer drug since around 20153 and has a short history of human use.

Dosage & Duration

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Dosage

Doses are population estimates that vary widely between individuals.

Threshold~5 mg
Light5-15 mg
Moderate15-35 mg
Strong35-60 mg
Heavy60+ mg

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
white → blue2
Mecke(ME)
white → brown3 → black3
Mandelin(MD)
yellow2 → brown3
Liebermann(LB)
white → black3
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Pharmacology

Pharmacodynamics

HDEP-28 is suspected to inhibit serotonin, norepinephrine, and dopamine reuptake, based on its structural similarity to HDMP-28.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

HDEP-28 has habit-forming potential.

History & Culture

HDEP-28 was sold as a designer drug from around 20153 and had a short history of human use.

Legality

Legality not written up yet

References

Citations

  1. The challenge of New Psychoactive Substances: A technical update 2024. United Nations Office on Drugs and Crime (2024). https://www.minjusticia.gov.co/programas-co/ODC/Documents/SAT/The_Challenge_of_NPS_A_technical_update_2024.pdf1
  2. Pharmacological profile of methylphenidate-based designer drugs. Neuropharmacology (2017). https://doi.org/10.1016/j.neuropharm.2017.08.0201
  3. Use of cognitive enhancers: methylphenidate and analogs. European Review for Medical and Pharmacological Sciences (2019). https://doi.org/10.26355/eurrev_201901_1674112

Further Reading

  1. Klare et al. 2017 - Analysis of six ‘neuro‐enhancing’ phenidate analogs

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed: this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

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