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Ethaqualone

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Subjective Effects
Interactions
Legality
Ethaqualone molecule structureEthaqualone molecule structure
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Chemical Class
Quinazolinone

Ethaqualone is a quinazolinone depressant and an analogue of methaqualone with sedative, sleep-inducing, and muscle-relaxing effects.1 It was developed in the 1960s1 and marketed mainly in France2, where it was used to treat insomnia.2 It is reported to be slightly weaker and shorter acting than methaqualone. Ethaqualone can be habit-forming and can impair memory and coordination. Combining it with other depressants can intensify its effects and cause overdose.

Dosage & Duration

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Dosage

Doses are population estimates that vary widely between individuals.

Threshold~100 mg
Light100-175 mg
Moderate175-300 mg
Strong300-450 mg
Heavy450+ mg

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacodynamics

Ethaqualone acts as an agonist at the β-subtype of the GABA-A receptor, contributing to its central nervous system depressant action. It is also thought to increase GABA-A receptor sensitivity.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

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Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Cross Tolerance

Benzodiazepines, Alcohol

Harm Potential

Addiction & Dependence

Psychological

Moderate

Classified as habit-forming, suggesting notable potential for psychological dependence with repeated use.

History & Culture

Ethaqualone was developed in the 1960s1 and was used to treat insomnia.3 It was marketed primarily in France and other European countries, and later in China, where it remained in clinical use as of 2022. Trade names included Aolan, Athinazone, and Ethinazone.

Legality

Legality not written up yet

References

Citations

  1. Advances in synthesis and biological activities of quinazoline scaffold analogues: A review. Arabian Journal of Chemistry (2023). https://doi.org/10.1016/j.arabjc.2023.105190123
  2. Synthesis and anticonvulsant evaluation of some novel 4(3H)-quinazolinones. ResearchGate, author-uploaded Monatshefte für Chemie article (2011). https://doi.org/10.1007/s00706-011-0525-312
  3. At-a-glance: New psychoactive substances in Canada - 2022. Health Canada (2023). https://www.canada.ca/en/health-canada/services/publications/healthy-living/new-psychoactive-substances-canada-2022.html1

Article Status

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    Step 1 · Automated synthesis

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    Not yet reviewed: this article is pending editorial review by Lyrea.

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