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ETH-CAT

ETH-CAT molecule structureETH-CAT molecule structure

ETH-CAT is an N-alkylated synthetic cathinone1 with empathogenic qualities. It is described as producing relatively mild stimulation and limited euphoria, giving it a more functional character. Its main effects are short-lived, although subtle stimulation reportedly persists afterward. The short active duration can encourage compulsive redosing. Adverse effects include insomnia, jaw tension, and teeth grinding. It has also reportedly been sold as ecstasy alongside mephedrone.

Dosage & Duration

Log in Piru

Dosage

Doses are population estimates that vary widely between individuals.

Threshold5-20 mg
Light15-35 mg
Moderate35-75 mg
Strong225-325 mg
Heavy300 mg

Although reports on ethylcathinone use are relatively scarce, available information indicates patterns consistent with other substituted cathinones. Compulsive redosing appears common, with users frequently combining routes of administration—for example, alternating between oral and insufflated doses within a single session. The urge to recapture initial effects often leads to subsequent doses that exceed the starting amount or are taken in rapid succession. Many experience reports describe difficulty resisting additional doses once effects begin to diminish, with some users unintentionally consuming a gram or more in a single session. Individual responses to any given dose can vary substantially, and what produces manageable effects in one person may be dangerous for another.

Duration

Onset15-45 minutes
Come Up15-30 minutes
Peak30-45 minutes
Offset30-90 minutes
After Effects2-4 hours
Total2-5 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacodynamics

ETH-CAT acts primarily as a norepinephrine releasing agent and is a selective substrate for the norepinephrine transporter (NET). It also inhibits dopamine reuptake2, although this activity is relatively weak.

Pharmacokinetics

ETH-CAT is expected to undergo N-dealkylation to a more active metabolite, but this metabolic pathway is proposed rather than established.

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.

Full Tolerance
Tolerance to many of ETH-CAT's effects develops with prolonged, repeated use, so progressively larger doses are needed to produce the same effects.
Baseline Reset
Tolerance returns to baseline after approximately 3–5 days without further use.
Half Tolerance
Tolerance falls to approximately half its previous level after 2–3 days without further use.
Cross Tolerance

All dopaminergic stimulants

Harm Potential

Addiction & Dependence

Psychological

Low

Chronic ETH-CAT use is considered mildly addictive, with a low potential for abuse, although psychological dependence can develop in some users and insufflation is more associated with compulsive use. Many users report difficulty resisting redosing after a strong dose as effects subside, and reports of unexpectedly consuming a gram or more are common.

Physical

Low

Physical dependence appears unlikely, with withdrawal symptoms expected to be minimal and unlikely to be life-threatening.

Toxicity

Lethal Dosage

The exact toxic dose of ETH-CAT is unknown.

History & Culture

Rothman and Baumann included ethcathinone alongside other psychostimulants in a 2006 paper on its pharmacology.…

Legality

International

Grey-area status is reported in many jurisdictions.

By Country

Illegal11
United States flagUnited StatesIllegal
Brazil flagBrazilIllegal
Canada flagCanadaIllegal (analog/blanket ban)
China flagChinaIllegal
Denmark flagDenmarkIllegal
Germany flagGermanyIllegal
Israel flagIsraelIllegal
Poland flagPolandIllegal
Sweden flagSwedenIllegal
Switzerland flagSwitzerlandIllegal
United Kingdom flagUnited KingdomIllegal

References

Citations

  1. Synthetic Cathinones: Recent Developments, Enantioselectivity Studies and Enantioseparation Methods. Molecules (2022). https://doi.org/10.3390/molecules270720571
  2. Monoamine transporter and receptor interaction profiles of a new series of designer cathinones. Neuropharmacology (2014). https://doi.org/10.1016/j.neuropharm.2013.11.008123
  3. 我国管制毒品目录(2026年7月更新,540种+三大类). ga.sz.gov.cn (n.d.). https://ga.sz.gov.cn/SZJDZX/SZBMFW/content/post_12898420.html1
  4. 三部门联合发布最新版《非药用类麻醉药品和精神药品目录》. btgaj.xjbt.gov.cn (n.d.). https://btgaj.xjbt.gov.cn/c/2025-07-28/8428464.shtml1
  5. 非药用类麻醉药品和精神药品列管办法. gaj.panjin.gov.cn (n.d.). https://gaj.panjin.gov.cn/2015_10/08_00/content-235605.html1
  6. 中华人民共和国禁毒法. sz.gov.cn (n.d.). https://www.sz.gov.cn/cn/xxgk/zfxxgj/zcfg/content/post_8979670.html1
  7. Resolução da Diretoria Colegiada Anvisa nº 1.036, de 09/07/2026. anvisalegis.datalegis.net (n.d.). https://anvisalegis.datalegis.net/action/ActionDatalegis.php?acao=abrirTextoAto&tipo=RDC&numeroAto=00001036&seqAto=000&valorAno=2026&orgao=RDC/DC/ANVISA/MS&codTipo=&desItem=&desItemFim=&cod_menu=1696&cod_modulo=134&pesquisa=true1
  8. Resolução-RDC nº 49, de 11 de novembro de 2015. gov.br (n.d.). https://www.gov.br/anvisa/pt-br/assuntos/medicamentos/controlados/lista/arquivos-controlados/6560json-file-1/@@display-file/file1
  9. Portaria - PRT nº 344, de 12/05/1998. anvisalegis.datalegis.net (n.d.). https://anvisalegis.datalegis.net/action/ActionDatalegis.php?acao=abrirTextoAto&tipo=POR&numeroAto=00000344&seqAto=000&valorAno=1998&orgao=SVS/MS&codTipo=&desItem=&desItemFim=&cod_menu=1696&cod_modulo=134&pesquisa=true1
  10. Lei nº 11.343, de 23 de agosto de 2006 — texto atualizado. www2.camara.leg.br (n.d.). https://www2.camara.leg.br/legin/fed/lei/2006/lei-11343-23-agosto-2006-545399-normaatualizada-pl.html1

Further Reading

  1. Nadal-Gratacós et al. 2023 - Structure–Activity Relationship of N -Ethyl-Hexedrone Analogues: Role of the α-Carbon Side-Chain Length in the Mechanism of Action, Cytotoxicity, and Behavioral Effects in Mice

Article Status

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