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DON

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Subjective Effects
Interactions
Tolerance
Legality
DON molecule structureDON molecule structure
Open in Piru
Chemical Class
DOx

DON is a rare psychedelic amphetamine in the phenethylamine, amphetamine, and DOx families. It produces pronounced hallucinogenic and amphetamine-like stimulant effects, distinguishing it from related substances such as DOB. Anecdotal reports suggest its bodily effects are rougher than those of other DOx compounds, sometimes involving physical pain.

Dosage & Duration

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Dosage

Doses are population estimates that vary widely between individuals.

Threshold2 mg
Light3 mg
Moderate3-5 mg
Heavy5+ mg

These doses are preliminary; further research is advised.

Duration

Onset30-120 minutes
After Effects12-24 hours
Total14-22 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacodynamics

DON acts primarily as a partial agonist at serotonin 5-HT2A and 5-HT2C receptors, with substantially lower potency and efficacy than other DOx compounds. It is also a partial agonist at 5-HT2B receptors1, while an earlier study reported affinity at rat cortical serotonin 5-HT2 and 5-HT1 binding sites.2 DON is inactive as a monoamine oxidase inhibitor. In rodents, it produces the head-twitch response, a behavioral proxy of psychedelic-like activity, with potency and efficacy similar to DOM in this assay.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Toxicity

Gastrointestinal

Stomach cramps have been reported during acute intoxication at typical doses.

Thermoregulatory

Slight hypothermia has been reported as a physical effect during intoxication.

History & Culture

DON was described in scientific literature by Ronald Coutts and Jerry Malicky by 1973.4 Juan Gomez-Jeria and colleagues described its electronic structure and reported hallucinogenic effects of the racemic compound in 1987.5 Alexander Shulgin…

Legality

Legality not written up yet

References

Citations

  1. Binding and functional structure-activity similarities of 4-substituted 2,5-dimethoxyphenyl isopropylamine analogues at 5-HT2A and 5-HT2B serotonin receptors. Frontiers in Pharmacology (2023). https://doi.org/10.3389/fphar.2023.110129012
  2. 5-HT_1 and 5-HT_2 binding properties of derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane (2,5-DMA). European Journal of Pharmacology (1984). https://doi.org/10.1016/0014-2999(84)90333-912
  3. Differences in potency and efficacy of a series of phenylisopropylamine/phenylethylamine pairs at 5-HT2A and 5-HT2C receptors. British Journal of Pharmacology (2002). https://doi.org/10.1038/sj.bjp.070474712
  4. The synthesis of some analogs of the hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM). Canadian Journal of Chemistry (1973). https://doi.org/10.1139/v73-2101
  5. A quantum-chemical and experimental study of the hallucinogen (±)-1-(2,5-dimethoxy-4-nitrophenyl)-2-aminopropane (DON). Biblioteca Digital - Universidad de Chile (1987). https://doi.org/10.1016/0223-5234(87)90032-81
  6. PiHKAL: #70 DON. Erowid (1991). https://www.erowid.org/library/books_online/pihkal/pihkal070.shtml1
  7. Analysis of Newly Distributed Designer Drugs Detected in the Products Purchased in Fiscal Year 2008. Yakugaku Zasshi (Journal of the Pharmaceutical Society of Japan) (2010). https://www.jstage.jst.go.jp/article/yakushi/130/2/130_2_263/_pdf1

Article Status

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    Step 1 · Automated synthesis

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