Skip to main content
L

Not yet reviewed: this article is pending editorial review by Lyrea.

Citation noticeOur citation system is being overhauled

References and citation markers may currently be incomplete, mismatched, or incorrect. This system is being rebuilt and reviewed before the full site launch.

DMAA

This article is a stubmissing:
Subjective Effects
Interactions
Tolerance
Legality
DMAA molecule structureDMAA molecule structure
Open in Piru
Chemical Class
Amine

2-amino-4-methylhexane was described in a 1944 patent assigned to Eli Lilly and Company1 as a nasal decongestant1. It has also been marketed in weight-loss products2 and marketed, sometimes improperly, as a dietary supplement2 or ingredient in energy drinks. DMAA carries a risk of heart attack2, stroke3, and other potentially life-threatening cardiovascular problems.

Dosage & Duration

Log in Piru

Dosage

Doses are population estimates that vary widely between individuals.

Threshold5-10 mg
Light10-20 mg
Moderate20-50 mg
Strong50-100 mg
Heavy100+ mg

Effects typically begin rapidly after oral administration.

Duration

Total2-4 hours

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Mandelin(MD)
yellow2 → orange2 → red2
Simons(SI)
orange1 → red1 → purple2 → purple3
Marquis(MQ)
No reaction
No reaction
Liebermann(LB)
No reaction
No reaction
Powered by PROtestkit.eu

Pharmacology

Pharmacodynamics

DMAA is characterized as an indirect sympathomimetic amine vasoconstrictor4, indicating pharmacological effects that mimic activation of the sympathetic nervous system5.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Moderate

Classified as habit-forming. As a stimulant, it carries potential for psychological dependence with regular use.

Toxicity

Cardiovascular

DMAA use has been associated with serious cardiovascular harms, including myocardial infarction, stroke, and other potentially fatal events.

History & Culture

A patent granted in 1944 and assigned to Eli Lilly and Company described 2-amino-4-methylhexane for treating nasal congestion by inhalation.1 It was marketed in weight-loss products, including products sold as dietary supplements2 and as an ingredient in some energy drinks6.

Legality

Legality not written up yet

References

Citations

  1. Aminoalkanes. Google Patents (1944). https://patents.google.com/patent/US2350318A/en123
  2. DMAA in Products Marketed as Dietary Supplements. U.S. Food and Drug Administration (2018). https://www.fda.gov/food/information-select-dietary-supplement-ingredients-and-other-substances/dmaa-products-marketed-dietary-supplements1234
  3. Scientific Memorandum: 1,3-dimethylamylamine (1,3-DMAA). U.S. Food and Drug Administration (2016). https://www.fda.gov/media/169553/download1
  4. Scientific Memorandum: 1,3-dimethylamylamine (1,3-DMAA). U.S. Food and Drug Administration (2021). https://www.fda.gov/media/169554/download?attachment=1
  5. Report of the Department of Defense 1,3 Dimethylamylamine (DMAA) Safety Review Panel. U.S. Department of Defense report hosted by Schmidt & Clark (2013). https://www.schmidtlaw.com/wp-content/uploads/Report-of-the-DoD-DMAA-Safety-Review-Panel-2013.pdf1
  6. Influence of energy drink ingredients on mood and cognitive performance. Wiley Online Library (2014). https://doi.org/10.1111/nure.121481

Further Reading

  1. Zhang et al. 2012 - 1,3‐Dimethylamylamine (DMAA) in supplements and geranium products: natural or synthetic?

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed: this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Suggest an edit

Spotted a mistake, an outdated claim, or something missing from the DMAA article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.

Wish to give generalised feedback? You can do so here.