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Dimemebfe

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Interactions
Tolerance
Harm Potential
History & Culture
Legality
Dimemebfe molecule structureDimemebfe molecule structure
Open in Piru
Chemical Class
Tryptamine

Dimemebfe may be considered a benzofuran analog of 5-MeO-DMT, with oxygen replacing the indole nitrogen1. It is described as producing effects somewhat similar to psilocybin mushrooms, with additional empathogenic effects. In receptor-binding assays using rat brain homogenate, tertiary benzofuran amines had approximately one-sixth the 5-HT2 receptor affinity of the corresponding indoles2. Dimemebfe is described as less potent than 5-MeO-DMT and is described as much less potent overall. Its psychoactive classification remains tentative.

Dosage & Duration

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Dosage

Doses are population estimates that vary widely between individuals.

Threshold~25 mg
Light25-50 mg
Moderate50-75 mg
Strong75-125 mg
Heavy125+ mg

Duration

Onset10-40 minutes
Total4-6 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

Reported as broadly resembling the experience of psilocybin mushrooms, with an additional empathogenic character.

Cognitive

An empathogenic quality is noted alongside the psilocybin-like headspace.

Empathy enhancement

Pharmacology

Pharmacodynamics

Dimemebfe acts as an agonist at the 5-HT1A and 5-HT2 families of serotonin receptors, with its strongest activity at the 5-HT2 family. Compared with 5-MeO-DMT, it is several times less potent as a serotonin agonist and shows relatively greater activity at 5-HT1A receptors.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Harm Potential not written up yet

History & Culture

History & Culture not written up yet

Legality

Legality not written up yet

References

Citations

  1. The Characterization of 2-(5-Methoxy-1-benzofuran-3-yl)-N,N-dimethylethanamine (5-MeO-BFE) and Differentiation from its N-Ethyl Analog. Microgram Journal, U.S. Drug Enforcement Administration (2012). https://www.dea.gov/sites/default/files/pr/microgram-journals/2012/mj9-1_39-45.pdf1
  2. Benzofuran bioisosteres of hallucinogenic tryptamines. Journal of Medicinal Chemistry (1992). https://doi.org/10.1021/jm00089a0171

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

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    Not yet reviewed: this article is pending editorial review by Lyrea.

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