Skip to main content
L

Not yet reviewed: this article is pending editorial review by Lyrea.

Citation noticeOur citation system is being overhauled

References and citation markers may currently be incomplete, mismatched, or incorrect. This system is being rebuilt and reviewed before the full site launch.

Dehydroxyfluorafinil

Dehydroxyfluorafinil molecule structureDehydroxyfluorafinil molecule structure
N-Methyl-4,4'-difluoro-modafinil
N-Methylbisfluoromodafinil, Modafiendz, FiendzOpen in Piru
Psychoactive Class
NootropicEugeroicStimulant

Dehydroxyfluorafinil is a benzhydryl diphenylmethylsulfinylacetamide and modafinil analogue classified as a nootropic, eugeroic, and stimulant. It is a wakefulness-promoting agent1 related to modafinil and adrafinil1, described as a bis-fluoro, N-methylated derivative1 that was never marketed and is sold online for non-medical use. Users report sharpness and stimulation; occasional internet reports associate it with jitters and vasoconstriction.

Dosage & Duration

Log in Piru

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~50 mg
Light50-100 mg
Moderate100-150 mg
Strong150-200 mg
Heavy200+ mg

Duration

Onset30-60 minutes
After Effects2-24 hours
Total5-8 hours

Subjective Effects

Legacy content. A statistically backed ontology from Mindstate Design Labs is coming soon.

Effects vary widely by individual, dose, and context.

Physical

Increased heart rateDizzinessNausea

Cognitive

Focus enhancementWakefulnessThought accelerationMemory enhancementMotivation enhancementEmotion enhancementAnxiety
Forked from Subjective Effect Documentation byJosie Kins July 2016.

Pharmacology

Pharmacodynamics

As a modafinil analogue2, dehydroxyfluorafinil is reported to act as a selective dopamine reuptake inhibitor. This action is thought to contribute to the wakefulness-promoting effects of modafinil analogues.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Toxicity

Cardiovascular

Internet reports mention jitters and vasoconstriction.

History & Culture

Dehydroxyfluorafinil was never marketed as a pharmaceutical but was sold online for non-medical use as a nootropic. Some research chemical vendors branded it as “Modafiendz.” The legally available, non-prescription product was moderately popular around 2015 and was purchased through research chemical vendors.

Legality

International

Legally available as a non-prescription stay-awake product circa 2015.

References

Source Pages

  1. Bluelight: Legal high similar to speed (UK)
  2. Bluelight: N-Methyl-4,4-Difluoro-Modafinil
  3. Drug Users Bible - Modafiendz
  4. Drug Users Bible by Dominic Milton Trott
  5. PsychonautWiki: N-Methylbisfluoromodafinil
  6. Wikipedia

Citations

  1. Outsmarted by nootropics? An investigation into the thermal degradation of modafinil, modafinic acid, adrafinil, CRL-40,940 and CRL-40,941 in the GC injector: formation of 1,1,2,2-tetraphenylethane and its tetra fluoro analog. LJMU Research Online (2017). https://doi.org/10.1002/dta.2142123
  2. The Psychonauts’ World of Cognitive Enhancers. Frontiers in Psychiatry (2020). https://doi.org/10.3389/fpsyt.2020.5467961

Further Reading

  1. BenchChem listing (CAS 1613222-54-0)
  2. Cayman Chemical product information PDF
  3. Cayman Chemical product page
  4. Drugs.com - Caffeine × Modafinil interaction
  5. Drugs.com - Modafinil interactions list
  6. PubMed: Modafinil half-life study
  7. Reddit: / r/Nootropics – New eugeroic Modafiendz
  8. Reddit: / r/researchchemicals – Dose comparison
  9. UK Psychoactive Substances Act 2016
  10. ZeptoMetrix Modafiendz product page

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed: this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Suggest an edit

Spotted a mistake, an outdated claim, or something missing from the Dehydroxyfluorafinil article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.

Wish to give generalised feedback? You can do so here.