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D2PM

This article is a stubmissing:
Subjective Effects
Interactions
Tolerance
D2PM molecule structureD2PM molecule structure
Diphenylprolinol
Head Candy, NRG-3, BenzofuryOpen in Piru
Psychoactive Class
Stimulant
Chemical Class
Pipradrol homologue

D2PM is a stimulant in the pipradrol homologue class. Based on the published data reviewed, its binding and activity at the dopamine reuptake transporter were described as similar to cocaine's, although D2PM appeared to have less biological activity1, although cocaine is probably more recreational for most people. The cited review reported no deaths directly attributed to D2PM1.

Dosage & Duration

Log in Piru

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~15 mg
Light15-20 mg
Moderate20-40 mg
Strong40-50 mg
Heavy50+ mg

Duration

Onset20-30 minutes
After Effects1-6 hours
Total2-5 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacodynamics

The R-(+)-enantiomer of D2PM was tested in vitro for dopamine transporter binding and dopamine uptake inhibition using Chinese hamster ovary cells expressing human dopamine transporter2. The R-(+)-enantiomer is more pharmacologically active than the S-(-)-enantiomer, and its DAT uptake-inhibition potency is reported as similar to cocaine2. Evidence for the norepinephrine component is limited to the reported NDRI classification.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Moderate

Classified as habit-forming. As a stimulant with dopamine and norepinephrine reuptake inhibition, it carries potential for compulsive use patterns typical of this drug class.

Toxicity

Lethal Dosage

No deaths have been reported so far. Overdoses have led to hospital visits with prolonged stimulation and psychological effects persisting for over 24 hours.

Cardiovascular

Acute cardiovascular effects including tachycardia, hypertension, and chest pain suggestive of possible cardiovascular toxicity have been reported following recreational use; serious cardiac events appear associated with higher doses or combination use.

Central Nervous System

In vitro studies suggest D2PM may be more neurotoxic than MDMA or MDA at the cellular level, inhibiting normal neurite outgrowth; clinical significance in humans at recreational doses is not established.

Psychosis Risk

Moderate

Paranoia and visual hallucinations have been reported in multiple case reports, particularly at higher doses or in overdose situations. Psychological symptoms including paranoia and anxiety may persist for 48-96 hours post-administration.

History & Culture

Development and first detection

Guilford Pharmaceuticals Inc. filed a patent for D2PM in 1997, describing it as a dopamine transporter inhibitor. Its activity was explored only to a limited degree. D2PM was first detected in 2007 in tablets purchased from an online store during testing at St. George’s University in London, and it

Legality

By Country

Legal / decriminalized1
United States flagUnited StatesUncontrolled

References

Source Pages

  1. Bluelight: D2PM experiences thread
  2. The Drug Classroom
  3. TripSit: D2PM Factsheet
  4. Wikipedia

Citations

  1. Use and acute toxicity associated with the novel psychoactive substances diphenylprolinol (D2PM) and desoxypipradrol (2-DPMP). Clinical Toxicology (2012). https://doi.org/10.3109/15563650.2012.71615812
  2. Pharmaceutical Compositions and Methods for Treating Compulsive Disorders Using Pyrrolidine Derivatives. United States Patent and Trademark Office (1999). https://patentimages.storage.googleapis.com/da/e2/4e/d4326ca18e5583/US5925666.pdf123
  3. 2-DPMP (desoxypipradrol, 2-benzhydrylpiperidine, 2-phenylmethylpiperidine) and D2PM (diphenyl-2-pyrrolidin-2-yl-methanol, diphenylprolinol): A preliminary review. Progress in Neuro-Psychopharmacology & Biological Psychiatry (2012). https://doi.org/10.1016/j.pnpbp.2012.05.02112
  4. Cardiovascular toxicity associated with recreational use of diphenylprolinol (diphenyl-2-pyrrolidinemethanol [D2PM]). PubMed (2008). https://doi.org/10.1007/bf031611951

Further Reading

  1. ACMD advice on diphenyl-2-pyrrolidinyl-methanol (D2PM)
  2. Corkery JM et al. 2-DPMP and D2PM: A preliminary review. Prog Neuropsychopharmacol Biol Psychiatry 2012
  3. Corkery JM et al. Preliminary review of D2PM and 2-DPMP. Prog Neuro-Psychopharmacol 2012
  4. Drugs-Forum: D2PM experiences thread
  5. Meltzer SC et al. Receptor binding profile of diphenylprolinol. J Psychopharmacol 2010
  6. ScienceDirect: Topics – user dose reports (20-50 mg oral, 5-10 h duration)
  7. Simmler et al. 2014 - Pharmacological profiles of aminoindanes, piperazines, and pipradrol derivatives

Article Status

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