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Cyclopropylmescaline

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Subjective Effects
Interactions
Tolerance
Legality
Cyclopropylmescaline molecule structureCyclopropylmescaline molecule structure
Open in Piru
Chemical Class
Scaline

Cyclopropylmescaline (CPM) is a psychedelic phenethylamine in the scaline family, related to mescaline. Alexander Shulgin produced it and described it in scientific literature by 1994. PiHKAL reports a duration of 12–18 hours and describes prominent eyes-closed imagery in an account involving 70 mg1. Chemically, CPM replaces mescaline’s methoxy methyl group with a cyclopropylmethyl group1.

Dosage & Duration

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Dosage

Doses are population estimates that vary widely between individuals.

Threshold~50 mg
Light50-60 mg
Moderate60-70 mg
Strong70-80 mg
Heavy80+ mg

Duration

Onset10-30 minutes
After Effects6-8 hours
Total12-18 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacodynamics

Cyclopropylmescaline acts as a full agonist at serotonin 5-HT2 receptors. This includes agonism at the 5-HT2A2, 5-HT2B, and 5-HT2C receptor subtypes.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Psychosis Risk

Low

Reports describe hallucinations, intrusive or irritating sounds, feelings of vulnerability, and sleep interference during a long-lasting psychedelic experience. Persistent psychosis is not established by the available reports.

History & Culture

Cyclopropylmescaline (CPM) was produced and described by Alexander Shulgin. PiHKAL includes a description of cyclopropylmescaline3.

Legality

Legality not written up yet

References

Citations

  1. PIHKAL - #37 CPM. Erowid Online Books (1991). https://erowid.org/library/books_online/pihkal/pihkal037.shtml12
  2. Receptor Interaction Profiles of 4-Alkoxy-3,5-Dimethoxy-Phenethylamines (Mescaline Derivatives) and Related Amphetamines. Frontiers in Pharmacology (2021). https://doi.org/10.3389/fphar.2021.79425412
  3. PiHKAL: A Chemical Love Story. Transform Press (1991). https://projectavalon.net/lib/Alexander%20and%20Ann%20Shulgin%20-%20Pihkal%20-%20Phenethylamines%20I%20Have%20Known%20And%20Loved%202.pdf1

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

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