Skip to main content
L

Not yet reviewed: this article is pending editorial review by Lyrea.

Citation noticeOur citation system is being overhauled

References and citation markers may currently be incomplete, mismatched, or incorrect. This system is being rebuilt and reviewed before the full site launch.

Clonitazene

This article is a stubmissing:
Subjective Effects
Interactions
Tolerance
History & Culture
Legality
Clonitazene molecule structureClonitazene molecule structure
Open in Piru
Chemical Class
Nitazene

Clonitazene belongs to the 2-benzyl benzimidazole opioid family known as nitazenes, which were originally developed as analgesics1. It is classified as a depressant and habit-forming substance. In the ACMD report's account of single oral doses administered to former morphine addicts, clonitazene appeared to be about one-third to one-fifth as potent as morphine sulphate1. Clonitazene is not currently marketed1, and its psychoactive class is otherwise listed as unknown.

Dosage & Duration

Log in Piru

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~2.5 mg
Light2.5-5 mg
Moderate5-10 mg
Strong10-15 mg
Heavy15+ mg

Duration

After Effects1-8 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacodynamics

Clonitazene is an opioid analgesic2 and was reported to be approximately three times as potent as morphine in a mouse tail-flick assay3.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

High

As a potent opioid, clonitazene carries significant psychological addiction potential with high abuse liability and reinforcing effects typical of the opioid class.

Physical

High

Physical dependence is expected to develop with regular use, consistent with other potent opioids. Withdrawal syndrome would be anticipated upon cessation.

Toxicity

Lethal Dosage

Clonitazene is approximately three times as potent as morphine. As a member of the nitazene family, which includes etonitazene at 1000-1500 times morphine potency, the lethal dose would be correspondingly lower than morphine in opioid-naive individuals.

History & Culture

History & Culture not written up yet

Legality

Legality not written up yet

References

Citations

  1. ACMD advice on 2-benzyl benzimidazole and piperidine benzimidazolone opioids. UK Government (2022). https://www.gov.uk/government/publications/acmd-advice-on-2-benzyl-benzimidazole-and-piperidine-benzimidazolone-opioids/acmd-advice-on-2-benzyl-benzimidazole-and-piperidine-benzimidazolone-opioids-accessible-version123
  2. WHO Expert Committee on Drug Dependence Forty-fifth report. World Health Organization (2022). https://www.drugsandalcohol.ie/38946/2/WHO_ECDD_45th_report.pdf1
  3. Synthesis, chemical characterization, and μ-opioid receptor activity assessment of the emerging group of “Nitazene” 2-benzylbenzimidazole synthetic opioids. ACS Chemical Neuroscience (2021). https://doi.org/10.1021/acschemneuro.1c000641

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed: this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

Suggest an edit

Spotted a mistake, an outdated claim, or something missing from the Clonitazene article? Send the editors a private note. Feedback lands in a moderation queue and is never shown on the site.

Wish to give generalised feedback? You can do so here.