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Choline Bitartrate

This article is a stubmissing:
Subjective Effects
Pharmacology
Interactions
Tolerance
History & Culture
Choline Bitartrate molecule structureCholine Bitartrate molecule structure
2-Hydroxy-N,N,N-trimethylethan-1-aminium
Choline, Vitamin B4
Psychoactive Class
Nootropic
Chemical Class
Ammonium salt

Dosage & Duration

Dosage

Doses are population estimates that vary widely between individuals.

Threshold50 mg
Light100-250 mg
Moderate250-1000 mg
Strong1000-2000 mg
Heavy2000+ mg
Bioavailability
40%

Duration

Onset45-75 minutes
Come Up15-30 minutes
Peak2-4 hours
Offset1-2 hours
After Effects2-8 hours
Total4-8 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacology not written up yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Extremely Low

Choline bitartrate is non-addictive and does not produce reinforcing effects that would lead to compulsive use patterns.

Physical

Extremely Low

As a naturally occurring nutrient precursor, choline bitartrate does not produce physical dependence or withdrawal symptoms.

Toxicity

Lethal Dosage

For humans, the estimated oral LD50 is roughly 200-400 grams calculated as choline, suggesting very low toxicity compared with ordinary supplemental amounts.

LD50 Data
SpeciesRouteValue
humanoral200-400 g (estimated range)
Gastrointestinal

High doses may cause gastrointestinal irritation including nausea, vomiting, and diarrhea; these effects are dose-dependent and typically occur only at doses significantly exceeding normal supplementation.

Integumentary

May cause skin irritation upon direct contact; can be harmful if absorbed through skin.

Central Nervous System

Large doses may cause dizziness, and depression or worsening depressive symptoms have been reported in people taking high-dose choline bitartrate.

History & Culture

History & Culture not written up yet

Legality

By Country

Legal / decriminalized2
United States flagUnited StatesLegal (regulated)
Germany flagGermanyLegal (regulated)

References

Source Pages

  1. Erowid: Choline Experience Vault
  2. PsychonautWiki
  3. Wikipedia

Citations

  1. Regulation (EU) No 609/2013, Article 1 and Article 4 (German consolidated text, 1 September 2025). eur-lex.europa.eu (n.d.). https://eur-lex.europa.eu/legal-content/DE/TXT/HTML/?uri=CELEX%3A02013R0609-202509011
  2. § 5 Nahrungsergänzungsmittelverordnung (NemV) — Anzeige. gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/nemv/__5.html1
  3. BVL — Regelungen für Online-Shops: Nahrungsergänzungsmittel. bvl.bund.de (n.d.). https://www.bvl.bund.de/DE/Arbeitsbereiche/01_Lebensmittel/04_AntragstellerUnternehmen/13_FAQ/FAQ_OnlineShops/FAQ_OnlineShops_node.html?cms_thema=Regelungen+f%C3%BCr+Online-Shops1
  4. PubChem PUG REST — Choline Bitartrate identity (CID 6900). pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/name/choline%20bitartrate/property/Title,IUPACName,MolecularFormula,CanonicalSMILES,IsomericSMILES/JSON1
  5. 21 CFR Part 182—Substances Generally Recognized as Safe (2025 edition), § 182.8250 Choline bitartrate. govinfo.gov (n.d.). https://www.govinfo.gov/content/pkg/CFR-2025-title21-vol3/pdf/CFR-2025-title21-vol3-part182.pdf1
  6. 21 CFR Part 101—Food Labeling (2025 edition), § 101.36 Nutrition labeling of dietary supplements. govinfo.gov (n.d.). https://www.govinfo.gov/content/pkg/CFR-2025-title21-vol2/pdf/CFR-2025-title21-vol2-part101.pdf1
  7. 21 CFR Part 107—Infant Formula (2025 edition), § 107.100 Nutrient specifications. govinfo.gov (n.d.). https://www.govinfo.gov/content/pkg/CFR-2025-title21-vol2/pdf/CFR-2025-title21-vol2-part107.pdf1
  8. FDA, Revocation of Certain Regulations Affecting Food, 61 FR 27771 (3 June 1996). govinfo.gov (n.d.). https://www.govinfo.gov/content/pkg/FR-1996-06-03/pdf/FR-1996-06-03.pdf1
  9. FDA, Substances Generally Recognized as Safe; Reorganization, 45 FR 58837 (5 September 1980). archives.federalregister.gov (n.d.). https://archives.federalregister.gov/issue_slice/1980/9/5/58837-58843.pdf1

Further Reading

  1. Frontiers: Choline Supplements - An Update (2023)
  2. Glier et al. - Methyl nutrients, DNA methylation, and cardiovascular disease (2014)
  3. Linus Pauling Institute - Choline
  4. Naber et al. - Improved human visuomotor performance after choline supplementation (2015)
  5. Nootropics Depot: Choline Supplements Guide
  6. Nootropics Expert: Choline Bitartrate
  7. Sitaram et al. - Interaction of choline and scopolamine in human memory (1978)
  8. Smolders et al. - Natural choline from egg yolk phospholipids is more efficiently absorbed (2019)
  9. Zeisel & Da Costa - Choline: An essential nutrient for public health (2009)

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed: this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

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