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Camazepam

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Subjective Effects
Interactions
Tolerance
Legality
Camazepam molecule structureCamazepam molecule structure
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Chemical Class
1,4-Benzodiazepine

Camazepam is a 1,4-benzodiazepine psychoactive drug with depressant and habit-forming properties. It is the dimethyl carbamate ester of temazepam and a metabolite of diazepam. Its anxiolytic effects are especially prominent, while anticonvulsant, hypnotic, and skeletal muscle relaxant effects are comparatively limited.1 The cited study concluded that camazepam is suitable for treating mild and severe anxiety states2, and its use can be habit-forming.

Dosage & Duration

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Dosage

Doses are population estimates that vary widely between individuals.

Threshold~10 mg
Light10-20 mg
Moderate20-40 mg
Heavy40+ mg

Duration

Onset45-90 minutes
After Effects1-12 hours
Total8-12 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacodynamics

Camazepam is a benzodiazepine that binds to the benzodiazepine site on GABA-A receptors and modulates GABA-mediated inhibitory signaling. Its anxiolytic activity is particularly prominent, while anticonvulsant, hypnotic, and skeletal muscle relaxant effects are comparatively limited. Animal studies report relatively low affinity at benzodiazepine receptors3, and anticonvulsant activity has been observed for camazepam and its active metabolite temazepam4.

Pharmacokinetics

After oral dosing, camazepam absorption was almost complete, and systemic availability in humans was greater than 90%5. It is metabolized to the active metabolite temazepam5. In dogs, the terminal elimination half-life ranged from 6.4 to 10.5 hours6.

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

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Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Moderate

Classified as habit-forming, consistent with the psychological dependence potential of the benzodiazepine class.

Toxicity

Dermatological

Camazepam use has been associated with reported skin disorders.

Central Nervous System

Higher doses (such as 40 mg) may cause disrupted sleep patterns and impaired cognitive performance.

History & Culture

Camazepam was marketed under the brand names Albego, Limpidon, and Paxor.7

Legality

Legality not written up yet

References

Citations

  1. Camazepam: Uses, Interactions, Mechanism of Action. DrugBank (n.d.). https://go.drugbank.com/drugs/DB014891
  2. Controlled double-blind trial of camazepam, a new benzodiazepine derivative, versus chlordiazepoxide. PubMed / European Journal of Clinical Pharmacology (1978). https://doi.org/10.1007/bf006446051
  3. Structure-Affinity Relationships Between Several New Benzodiazepine Derivatives and 3H-Diazepam Receptor Sites. Japanese Journal of Pharmacology (1984). https://doi.org/10.1016/s0021-5198(19)52298-312
  4. Receptor-mediated model relating anticonvulsant effect to brain levels of camazepam in the presence of its active metabolites. Journal of Pharmacokinetics and Biopharmaceutics (1986). https://doi.org/10.1007/bf011067091
  5. Species differences in the disposition and metabolism of camazepam. Xenobiotica (1985). https://doi.org/10.3109/00498258509049098123
  6. Pharmacokinetics of intravenous camazepam in dogs. Arzneimittelforschung (1982). https://pubmed.ncbi.nlm.nih.gov/61270871
  7. Camazepam acetonitrile 1mg/mL, certified reference material, ampule 1mL, Cerilliant. Merck/Sigma-Aldrich (2025). https://www.sigmaaldrich.com/GB/en/product/cerillian/c1761

Article Status

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