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Buphedrone

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Subjective Effects
Interactions
Tolerance
Legality
Buphedrone molecule structureBuphedrone molecule structure
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Buphedrone is a synthetic cathinone first synthesized in 1928 by Hyde and colleagues1. It is a β-ketone analogue of cathinone and is reported to be roughly two to three times more potent than methcathinone, although this estimate is uncertain. The free-base form is highly unstable and prone to dimerization, so buphedrone is commonly distributed as salts, especially the hydrochloride form.

Dosage & Duration

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Dosage

Doses are population estimates that vary widely between individuals.

Threshold~10 mg
Light10-30 mg
Moderate30-50 mg
Heavy50-80 mg

Duration

Onset10-20 minutes
After Effects1-8 hours

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Mandelin(MD)
yellow2 → orange2 → red2 → brown2 → yellow2
Liebermann(LB)
white → brown1
Simons(SI)
orange1 → blue2
Marquis(MQ)
No reaction
No reaction
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Pharmacology

Pharmacodynamics

Buphedrone potentiates dopamine release from dopaminergic nerve terminals in the brain, increasing endogenous dopamine concentrations. As a substituted cathinone, it is described as acting through binding to specific sites that increase endogenous monoamine levels rather than directly activating postsynaptic receptors, although the specific mechanism is not established.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Moderate

Classified as habit-forming. As a synthetic cathinone stimulant, it is expected to have abuse potential similar to other compounds in this class.

History & Culture

Buphedrone was first synthesized in 19281 as a synthetic analogue of cathinone, the stimulant naturally occurring in the khat plant. It belongs to the phenethylamine and cathinone chemical classes.2…

Legality

Legality not written up yet

References

Citations

  1. Perspectives on drugs: injection of synthetic cathinones. European Union Drugs Agency (2015). https://d9www.euda.europa.eu/topics/pods/synthetic-cathinones-injection_en12
  2. Currently Applied Naming Conventions for Various Subclassifications of Novel Psychoactive Substances. NIJ Forensic Technology Center of Excellence (2022). https://www.ojp.gov/pdffiles1/nij/grants/305761.pdf1

Further Reading

  1. Simmler et al. 2014 - Monoamine transporter and receptor interaction profiles of a new series of designer cathinones

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

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    Not yet reviewed: this article is pending editorial review by Lyrea.

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