Allylescaline
Allylescaline is a psychedelic substance in the phenethylamine and scaline classes, and is structurally related to mescaline and escaline. Otakar Leminger reported the compound in 1972,1 and Alexander Shulgin later discussed it in his 1991 book PiHKAL.2 It appeared as a novel designer drug in 2013.3 Allylescaline remains relatively uncommon, with little documented history of human use.
Dosage & Duration
Dosage
Doses are population estimates that vary widely between individuals.
Duration
Subjective Effects
Effects vary widely by individual, dose, and context.
Physical
Cognitive
Visual
Auditory
Pharmacology
Pharmacodynamics
In a 2025 in-vitro receptor screen, Allylescaline (allylmescaline) showed measurable binding at 5-HT1E, 5-HT2A, 5-HT2B and 5-HT2C. Binding was strongest at 5-HT2B among these measured targets. These affinity measurements do not by themselves establish partial- or full-agonist efficacy, human receptor occupancy, clinical potency or safety. [S1][S2]
Pharmacokinetics
There have been no studies on the pharmacokinetic profile of allylescaline and the metabolism of allylescaline is unknown.
Interactions
An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.
Tolerance
Tolerance timelines are rules of thumb, not exact schedules, and vary widely between individuals and use patterns.
Psychedelics
Harm Potential
Addiction & Dependence
Psychological
Extremely LowAllylescaline is not habit-forming, and the desire to use it can actually decrease with use. It is most often self-regulating.
Physical
Extremely LowNo evidence of physical dependence. The substance is described as not habit-forming.
History & Culture
Allylescaline was first documented in the scientific literature by Czech chemist Otakar Leminger in 1972.1 The compound received broader attention when American chemist Alexander Shulgin synthesized and characterized its psychoactive effects, publishing his findings…
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Legality
By Country
References
Source Pages
Citations
- Otakar Leminger. (1972). Příspěvek k chemii v jádře alkoxylovaných β-fenoetylaminů – II: O některých v jádře alkoxylovaných β-fenoetylaminech, resp. jejich sulfátech. Chemický Průmysl, 22, 553–557. https://isomerdesign.com/bitnest/external/ChemickyPrumysl/22.55312
- Alexander Shulgin, & Ann Shulgin. (1991). PiHKAL: A Chemical Love Story. Transform Press. https://www.erowid.org/library/books_online/pihkal/pihkal002.shtml123
- European Monitoring Centre for Drugs and Drug Addiction, & Europol. (2014). EMCDDA–Europol 2013 Annual Report on the implementation of Council Decision 2005/387/JHA. European Monitoring Centre for Drugs and Drug Addiction. https://www.euda.europa.eu/system/files/publications/814/TDAN14001ENN_475519.pdf1
- Anlage I BtMG (nicht verkehrsfähige Betäubungsmittel). gesetze-im-internet.de (n.d.). https://www.gesetze-im-internet.de/btmg_1981/anlage_i.html1
- 薬物乱用防止に関する情報 — Ministry of Health, Labour and Welfare. mhlw.go.jp (n.d.). https://www.mhlw.go.jp/stf/seisakunitsuite/bunya/kenkou_iryou/iyakuhin/yakubuturanyou/index.html1
- 指定薬物名称・構造式一覧 (current as of 27 August 2026). mhlw.go.jp (n.d.). https://www.mhlw.go.jp/content/11120000/001743040.pdf1
- 指定薬物一覧 (current as of 27 August 2026). mhlw.go.jp (n.d.). https://www.mhlw.go.jp/content/11120000/001743041.xlsx1
- 平成27年3月25日付けで以下の16物質が指定薬物に指定されました — MHLW. mhlw.go.jp (n.d.). https://www.mhlw.go.jp/seisakunitsuite/bunya/kenkou_iryou/iyakuhin/yakubuturanyou/oshirase/20150130-2.html1
- 医薬品、医療機器等の品質、有効性及び安全性の確保等に関する法律 (PMD Act). mhlw.go.jp (n.d.). https://www.mhlw.go.jp/web/t_doc?dataId=81004000&dataType=01
- About the Penalties for Drug Offenses in Japan — Designated Substances. mhlw.go.jp (n.d.). https://www.mhlw.go.jp/content/11120000/001682850.pdf1
- 麻薬及び向精神薬取締法 別表第1 (MHLW narcotics schedule). mhlw.go.jp (n.d.). https://www.mhlw.go.jp/content/11120000/001685509.pdf1
- 麻薬、麻薬原料植物、向精神薬、麻薬向精神薬原料等を指定する政令 第1条. mhlw.go.jp (n.d.). https://www.mhlw.go.jp/content/11120000/001733550.pdf1
- 麻薬及び向精神薬取締法 別表第3 (statutory psychotropics schedule). mhlw.go.jp (n.d.). https://www.mhlw.go.jp/content/11120000/001597636.pdf1
- 麻薬、麻薬原料植物、向精神薬、麻薬向精神薬原料等を指定する政令 (psychotropics decree schedule, Article 4). mhlw.go.jp (n.d.). https://www.mhlw.go.jp/content/11120000/001597642.pdf1
- 14 nya ämnen narkotikaklassas. Läkemedelsvärlden (n.d.). https://www.lakemedelsvarlden.se/14-nya-amnen-narkotikaklassas/1
- BetmVV-EDI, SR 812.121.11, consolidated stand 13 March 2026. fedlex.data.admin.ch (n.d.). https://fedlex.data.admin.ch/filestore/fedlex.data.admin.ch/eli/cc/2011/363/20260313/de/pdf-a/fedlex-data-admin-ch-eli-cc-2011-363-20260313-de-pdf-a-3.pdf1
- NIH PubChem PUG compound properties, CID 44719469. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/44719469/property/Title,IUPACName,CanonicalSMILES,InChIKey,MolecularFormula,MolecularWeight/JSON1
- NIH PubChem PUG synonyms, CID 44719469. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/44719469/synonyms/JSON12
- Swissmedic supplementary Verzeichnis-e list, stand 19 November 2024. swissmedic.ch (n.d.). https://www.swissmedic.ch/dam/swissmedic/de/dokumente/bewilligungen/btm/verzeichnis_der_rohmaterialienunderzeugnissemitvermuteterbetaeub.pdf.download.pdf/verzeichnis_der_rohmaterialienunderzeugnissemitvermuteterbetaeub.pdf1
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- The Psychoactive Substances Act 2016 (Commencement) Regulations 2016 (SI 2016/553). UK Government (n.d.). https://www.legislation.gov.uk/uksi/2016/553/made1
- NIH PubChem CID 44719469 property record — Allylescaline. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/44719469/property/IUPACName,MolecularFormula,CanonicalSMILES,IsomericSMILES/JSON1
- NIH PubChem CID 4076 property record — Mescaline. pubchem.ncbi.nlm.nih.gov (n.d.). https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/name/mescaline/property/IUPACName,MolecularFormula,CanonicalSMILES/JSON1
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Further Reading
- Reviewed & approved
Reviewed, edited, and approved by subject-matter expert Lyrea.
Automated synthesisInformation aggregated and synthesized using an autonomous workflow built by Josie Kins.
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