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Afloqualone

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Subjective Effects
Interactions
Tolerance
Legality
Afloqualone molecule structureAfloqualone molecule structure
Afloqualone
Arofuto, HQ-495, AroftOpen in Piru
Psychoactive Class
DepressantGABAergicSedative
Chemical Class
Quinazolinone

Afloqualone is a quinazoline-family GABAergic drug with sedative and muscle-relaxant effects1, developed in the 1970s by a Tanabe Seiyaku team as a rare analogue of methaqualone. It has had some clinical use1 but can rarely cause skin problems such as dermatitis and photosensitization that can lead to discontinuation of its use1.

Dosage & Duration

Log in Piru

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~50 mg
Light50-75 mg
Moderate75-100 mg
Strong100-200 mg
Heavy200+ mg

Duration

Onset60 minutes
After Effects1-3 hours
Total3-5 hours

Subjective Effects

Subjective Effects not written up yet

Pharmacology

Pharmacodynamics

Afloqualone acts as an agonist at the β subtype of the GABA-A receptor, enhancing GABAergic signaling associated with its sedative and muscle-relaxant effects.

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Addiction & Dependence

Psychological

Moderate

Classified as habit-forming, with abuse potential similar to other GABAergic sedatives such as benzodiazepines, barbiturates, and alcohol.

Toxicity

Dermatological

Causes photosensitization that can lead to skin problems including dermatitis; this side effect was significant enough to limit the drug's clinical adoption despite its sedative efficacy.

History & Culture

Afloqualone (Arofuto) was developed in the 1970s by a team at Tanabe Seiyaku as an analogue of methaqualone. It later saw some clinical use2.…

Legality

Legality not written up yet

References

Source Pages

  1. Bluelight: discussion - Afloqualone thread (user reports, 2015)
  2. TripSit: data sheet – Afloqualone
  3. Wikipedia

Citations

  1. Population Pharmacokinetic Modeling and Simulation of Afloqualone to Predict Steady-state Exposure Levels. International Journal of Pharmacology (2018). https://doi.org/10.3923/ijp.2018.276.284123
  2. Clinical Evaluation of Afloqualone on Masticatory Myofascial Pain and Temporomandibular Dysfunction. Journal of the Japanese Stomatological Society (1993). https://www.jstage.jst.go.jp/article/stomatology1952/42/2/42_2_357/_pdf1
  3. Afloqualone Photosensitivity: Immunogenicity of Afloqualone-Photomodified Epidermal Cells. Photochemistry and Photobiology (1994). https://doi.org/10.1111/j.1751-1097.1994.tb05102.x1
  4. Accidental afloqualone intoxication in two dogs. The Journal of Veterinary Medical Science (2017). https://doi.org/10.1292/jvms.17-03051

Further Reading

  1. Kawamura et al., Coma and seizure caused by afloqualone overdose, Pediatrics International 2019
  2. Nishimura et al., Photosensitizing Activities of Afloqualone, Jpn. J. Pharmacol. 1984
  3. Ochiai & Ishida, Pharmacological studies on afloqualone, Jpn. J. Pharmacol. 1982
  4. PubChem: CID 234274 - Afloqualone compound summary
  5. Reddit: /r/ObscureDrugs – Afloqualone experiences (2023)

Article Status

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    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

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    Not yet reviewed: this article is pending editorial review by Lyrea.

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