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Acetildenafil

This article is a stubmissing:
Subjective Effects
Interactions
Tolerance
Harm Potential
Legality
Acetildenafil molecule structureAcetildenafil molecule structure
Acetildenafil
HongdenafilOpen in Piru
Psychoactive Class
Not psychoactive

Acetildenafil is a synthetic pyrazolopyrimidinone and phosphodiesterase-5 (PDE5) inhibitor, and is not psychoactive. It is an analogue of sildenafil that has been detected, sometimes as an undisclosed ingredient, in herbal aphrodisiac and sexual-potency products.1 Although related compounds show PDE5 inhibitory activity in vitro, acetildenafil has not undergone formal human or animal testing, so its safety profile remains unknown and may pose health risks2.

Dosage & Duration

Log in Piru

Dosage

Doses are population estimates that vary widely between individuals.

Threshold~5 mg
Light5-15 mg
Moderate15-30 mg
Strong30-40 mg
Heavy40+ mg

Duration

Onset10-45 minutes
Total3-7 hours

Subjective Effects

Subjective Effects not written up yet

Reagent Testing

Expected colorimetric results for common reagent tests. Colors show reaction change over 1–2 minutes.

Marquis(MQ)
No reaction
No reaction
Mecke(ME)
No reaction
No reaction
Mandelin(MD)
No reaction
No reaction
Liebermann(LB)
No reaction
No reaction
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Pharmacology

Pharmacodynamics

Acetildenafil was found to be pharmacologically active on PDE5, the same enzyme as sildenafil.1 It has demonstrated PDE5 inhibitory activity in vitro,1 but its pharmacological effects have not been formally tested in humans or animals.3

Pharmacokinetics

Absorption & half-lifenot documented yetMetabolitesnone documented yet

Interactions

Interactions not written up yet

An unlisted combination is an unknown one, not a safe one. Check a dedicated combination chart before mixing.

Check TripSit

Tolerance

Tolerance not written up yet

Harm Potential

Harm Potential not written up yet

History & Culture

Acetildenafil was identified among compounds structurally similar to sildenafil in some herbal products marketed for treatment of erectile dysfunction4. The analysis confirmed acetildenafil in some herbal products marketed for treatment of erectile…

Legality

Legality not written up yet

References

Source Pages

  1. Bluelight: Acetildenafil (Hongdenafil) discussion thread
  2. TripSit Factsheets
  3. TripSit: Acetildenafil Factsheet

Citations

  1. Recent developments in counterfeits and imitations of Viagra, Cialis and Levitra: A 2005-2006 update. RIVM (2007). https://www.rivm.nl/bibliotheek/rapporten/370030001.pdf123
  2. Characterization of Sildenafil analogs by MS/MS and NMR: a guidance for detection and structure elucidation of phosphodiesterase-5 inhibitors. Journal of Pharmaceutical and Biomedical Analysis / PubMed (2014). https://doi.org/10.1016/j.jpba.2014.03.0381
  3. Analogues of erectile dysfunction drugs: an under-recognised threat. Hong Kong Medical Journal (2007). https://www.hkmj.org/system/files/hkm0710p359.pdf1
  4. Detection of sildenafil analogues in herbal products for erectile dysfunction. Journal of Toxicology and Environmental Health, Part A (2006). https://doi.org/10.1080/1528739060075135512
  5. Designer drugs in herbal aphrodisiacs. Forensic Science International (2008). https://doi.org/10.1016/j.forsciint.2007.11.00712

Further Reading

  1. Hefnawy M et al. Determination of acetildenafil in dietary supplements by LC–MS/MS. J Pharm Biomed Anal. 2019
  2. Kimera Chems – A Complete Guide for Acetildenafil (Reddit post)
  3. PDE5 Inhibitors - StatPearls - NCBI Bookshelf
  4. Venhuis BJ & de Kaste D. Sildenafil analogues as adulterants in herbal aphrodisiacs. Forensic Sci Int. 2012
  5. Venhuis BJ & de Kaste D. Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements. J Pharm Biomed Anal. 2012
  6. Venhuis BJ et al. Designer drugs in herbal aphrodisiacs. Forensic Sci Int. 2008

Article Status

  • Josie Kins avatar
    Step 1 · Automated synthesis

    An autonomous workflow built by Josie Kins compiled this article's foundation from information published across the web.

  • Step 2 · First-pass reviewPending

    Not yet reviewed: this article is pending editorial review by Lyrea.

  • Step 3 · Citation reviewPending

    No one has reviewed this article's citations yet. That second pass checks each claim against the source it cites.

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